SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		5 / 11 ILE A 104
ALA A 249
VAL A 118
LEU A 198
ALA A 121
 None
 1.04A 1n4hA-5y33A:
undetectable		 1n4hA-5y33A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 ARG A 195
TYR A 254
LYS A 252
 None
 1.04A 1uujB-5y33A:
undetectable		 1uujB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		4 / 8 HIS A 124
ILE A 119
TYR A 239
ARG A  74
 None
 1.04A 3ccfB-5y33A:
undetectable		 3ccfB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		4 / 7 TYR A 115
ASN A 193
LEU A 192
ASP A 106
 None
 1.37A 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable		 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		4 / 7 TYR A 115
ASN A 193
LEU A 192
ASP A 106
 None
 1.40A 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable		 3lslA-5y33A:
undetectable
3lslD-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		4 / 6 TYR A 115
ASN A 193
LEU A 192
ASP A 106
 None
 1.36A 3lslG-5y33A:
undetectable		 3lslG-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 ASP A 151
ARG A 156
TYR A 149
 None
 0.96A 5a7mA-5y33A:
undetectable		 5a7mA-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 ASP A 151
ARG A 156
TYR A 149
 None
 0.94A 5a7mB-5y33A:
undetectable		 5a7mB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 TYR A 115
SER A 108
TRP A 150
 None
 0.76A 5n8jB-5y33A:
undetectable		 5n8jB-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 TYR A 115
SER A 108
TRP A 150
 None
 0.75A 5n8jA-5y33A:
undetectable		 5n8jA-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		3 / 3 TYR A 115
SER A 108
TRP A 150
 None
 0.81A 5n8jD-5y33A:
undetectable		 5n8jD-5y33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5y33 ALGINATE LYASE
(Flavobacterium
sp.
UMI-01) 		5 / 12 ILE A 104
ILE A 120
ALA A 236
ILE A   6
ALA A   4
 None
 1.07A 5vceA-5y33A:
undetectable		 5vceA-5y33A:
10.64