SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5y35 -
(-) 		5 / 12 VAL B   7
LEU B 182
ILE B  74
GLY B  42
LEU B 233
 None
 0.94A 1cqeA-5y35B:
undetectable		 1cqeA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5y35 -
(-) 		5 / 12 VAL B   7
LEU B 182
ILE B  74
GLY B  42
LEU B 233
 None
 0.94A 1cqeB-5y35B:
undetectable		 1cqeB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5y35 -
(-) 		3 / 3 ALA B 110
VAL B 112
TRP B 115
 None
 0.85A 1nt5A-5y35B:
undetectable		 1nt5A-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5y35 -
(-) 		3 / 3 ALA B 110
VAL B 112
TRP B 115
 None
 0.85A 1nt5B-5y35B:
undetectable		 1nt5B-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5y35 -
(-) 		3 / 3 ALA B 110
VAL B 112
TRP B 115
 None
 0.81A 1nt6A-5y35B:
undetectable		 1nt6A-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5y35 -
(-) 		3 / 3 ALA B 110
VAL B 112
TRP B 115
 None
 0.81A 1nt6B-5y35B:
undetectable		 1nt6B-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5y35 -
(-) 		5 / 12 VAL B   7
LEU B 182
ILE B  74
GLY B  42
LEU B 233
 None
 0.92A 2aylB-5y35B:
undetectable		 2aylB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5y35 -
(-) 		3 / 3 TRP B 115
ALA B 110
VAL B 112
 None
 0.84A 2izqA-5y35B:
undetectable
2izqB-5y35B:
undetectable		 2izqA-5y35B:
undetectable
2izqB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5y35 -
(-) 		3 / 3 ASP B 221
TYR B   4
LYS B 176
 None
 1.21A 2othA-5y35B:
undetectable		 2othA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5y35 -
(-) 		4 / 8 GLY B 187
ASN B 188
PHE B  22
ARG B 191
 None
 1.26A 3ccfA-5y35B:
undetectable		 3ccfA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5y35 -
(-) 		5 / 12 ALA B  63
GLY B  24
SER B  58
LEU B  87
SER B 189
 None
 0.95A 3gyqA-5y35B:
undetectable
3gyqB-5y35B:
undetectable		 3gyqA-5y35B:
undetectable
3gyqB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5y35 -
(-) 		5 / 12 VAL B   7
LEU B 182
ILE B  74
GLY B  42
LEU B 233
 None
 0.90A 3n8zB-5y35B:
undetectable		 3n8zB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 5y35 -
(-) 		5 / 10 GLY B  49
ALA B  48
GLY B  42
VAL B  70
VAL B 217
 None
 1.02A 3oxwC-5y35B:
undetectable		 3oxwC-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 5y35 -
(-) 		4 / 8 ALA B 185
ILE B 183
LEU B 190
ALA B 163
 None
 0.71A 3r9tA-5y35B:
undetectable		 3r9tA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5y35 -
(-) 		4 / 5 TYR B  26
ILE B 136
LEU B  98
GLY B  97
 None
 0.95A 5kmdC-5y35B:
undetectable
5kmdD-5y35B:
undetectable		 5kmdC-5y35B:
undetectable
5kmdD-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5y35 -
(-) 		4 / 7 ASP B 221
ALA B   3
LYS B   5
LEU B 224
 None
 0.90A 6ci6A-5y35B:
undetectable		 6ci6A-5y35B:
undetectable