SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y37'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 7 VAL A 123
ILE A  17
TYR A 324
GLY A 153
 None
NAD  A 401 (-4.3A)
NAD  A 401 (-3.6A)
None
 0.92A 11gsA-5y37A:
undetectable		 11gsA-5y37A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 7 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 0.98A 1dssG-5y37A:
47.5		 1dssG-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		7 / 7 SER A 155
THR A 157
ASN A 159
CYH A 160
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.18A 1dssG-5y37A:
47.5		 1dssG-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 8 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 0.97A 1dssR-5y37A:
47.2		 1dssR-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		8 / 8 SER A 155
THR A 157
ASN A 159
CYH A 160
HIS A 183
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.43A 1dssR-5y37A:
47.2		 1dssR-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 9 THR A 125
LEU A 328
ILE A  25
VAL A   9
ILE A  96
 NAD  A 401 (-4.2A)
None
None
None
None
 1.29A 1gebA-5y37A:
undetectable		 1gebA-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 8 VAL A 123
ILE A  17
TYR A 324
GLY A 153
 None
NAD  A 401 (-4.3A)
NAD  A 401 (-3.6A)
None
 0.93A 2gssA-5y37A:
undetectable		 2gssA-5y37A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 8 VAL A 123
ILE A  17
TYR A 324
GLY A 153
 None
NAD  A 401 (-4.3A)
NAD  A 401 (-3.6A)
None
 0.94A 2gssB-5y37A:
undetectable		 2gssB-5y37A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 324
ALA A 126
ILE A 124
ALA A  21
ILE A  11
 NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
None
None
None
 1.04A 2h42B-5y37A:
undetectable		 2h42B-5y37A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 324
ALA A 126
ILE A 124
ALA A  21
ILE A  11
 NAD  A 401 (-3.6A)
NAD  A 401 (-3.3A)
None
None
None
 1.04A 2h42C-5y37A:
undetectable		 2h42C-5y37A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 6 THR A 301
ASP A 297
THR A 278
ASP A 286
 None
 1.22A 2okcB-5y37A:
2.6		 2okcB-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 8 VAL A  76
GLY A  68
LYS A  65
PRO A  42
 None
 0.94A 3bjwA-5y37A:
undetectable		 3bjwA-5y37A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 8 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 1.00A 3dmtC-5y37A:
46.7		 3dmtC-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		8 / 8 SER A 155
THR A 157
ASN A 159
CYH A 160
HIS A 183
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.36A 3dmtC-5y37A:
46.7		 3dmtC-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.86A 3hs6B-5y37A:
undetectable		 3hs6B-5y37A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 6 VAL A  78
VAL A  94
ILE A  87
ARG A  19
 None
 1.11A 3ms9A-5y37A:
undetectable		 3ms9A-5y37A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 6 VAL A  78
VAL A  94
ILE A  87
ARG A  19
 None
 1.13A 3mssA-5y37A:
undetectable		 3mssA-5y37A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		4 / 6 VAL A  78
VAL A  94
ILE A  87
ARG A  19
 None
 1.14A 3mssC-5y37A:
undetectable		 3mssC-5y37A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		3 / 3 ARG A  19
VAL A 288
THR A 244
 None
 0.58A 3ndtA-5y37A:
undetectable		 3ndtA-5y37A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 318
ASN A 230
GLY A 217
ALA A 218
GLY A 223
 None
 0.81A 4e1gA-5y37A:
undetectable		 4e1gA-5y37A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		3 / 3 THR A 158
ALA A 154
ASN A 159
 None
 0.57A 5ersA-5y37A:
3.3		 5ersA-5y37A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5y37 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Streptococcus
agalactiae) 		5 / 12 LEU A 233
ILE A 222
GLY A 217
LEU A 250
THR A 181
 None
 0.81A 5twjA-5y37A:
undetectable		 5twjA-5y37A:
undetectable