SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TRP C2164
VAL C2187
TRP C2245
 None
 1.24A 1c4dA-5y3rC:
undetectable
1c4dB-5y3rC:
undetectable		 1c4dA-5y3rC:
0.42
1c4dB-5y3rC:
0.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TRP C4121
ARG C3965
THR C4120
 None
 0.96A 1df7A-5y3rC:
undetectable		 1df7A-5y3rC:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLU C3140
PHE C3144
SER C3191
ILE C3193
LEU C3160
 None
 1.11A 1dlsA-5y3rC:
undetectable		 1dlsA-5y3rC:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE A 327
ARG A 325
TYR A 322
PHE B  88
 None
 1.46A 1e73M-5y3rA:
undetectable		 1e73M-5y3rA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 PHE C3942
LEU C3767
SER C3914
 None
 0.93A 1e7aA-5y3rC:
undetectable		 1e7aA-5y3rC:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY B 313
PRO B 322
ASP B 319
ALA A 113
 None
 0.90A 1gxsA-5y3rB:
undetectable
1gxsB-5y3rB:
undetectable		 1gxsA-5y3rB:
18.15
1gxsB-5y3rB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 THR C 481
SER C 480
TYR C 565
LEU C 564
 None
 1.13A 1ibgL-5y3rC:
undetectable		 1ibgL-5y3rC:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 LYS C4070
GLU C4069
ALA C4073
LEU C3857
GLU C4030
 None
 1.37A 1ie4A-5y3rC:
undetectable
1ie4C-5y3rC:
undetectable		 1ie4A-5y3rC:
3.15
1ie4C-5y3rC:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 SER C 882
PHE C3887
VAL C3930
SER C3907
 None
 1.06A 1kb9A-5y3rC:
undetectable
1kb9C-5y3rC:
undetectable
1kb9D-5y3rC:
undetectable
1kb9E-5y3rC:
undetectable		 1kb9A-5y3rC:
7.69
1kb9C-5y3rC:
6.75
1kb9D-5y3rC:
5.19
1kb9E-5y3rC:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ASP C2937
ALA C3909
SER C3906
HIS C3986
LEU C3988
 None
 1.27A 1kiaD-5y3rC:
undetectable		 1kiaD-5y3rC:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 ARG C3734
LEU C3680
ASN C3679
VAL C3728
 None
 1.26A 1lqtA-5y3rC:
undetectable		 1lqtA-5y3rC:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 ARG C3734
LEU C3680
ASN C3679
VAL C3728
 None
 1.26A 1lqtB-5y3rC:
undetectable		 1lqtB-5y3rC:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 ARG C3734
LEU C3680
ASN C3679
VAL C3728
 None
 1.26A 1lquA-5y3rC:
undetectable		 1lquA-5y3rC:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 ARG C3734
LEU C3680
ASN C3679
VAL C3728
 None
 1.27A 1lquB-5y3rC:
undetectable		 1lquB-5y3rC:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 ASP C3354
GLU C3350
LEU C3298
LEU C3348
 None
 1.01A 1np1A-5y3rC:
undetectable		 1np1A-5y3rC:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 GLU C  17
LEU C  12
LEU C  13
LEU C  15
 None
 1.14A 1np1A-5y3rC:
undetectable		 1np1A-5y3rC:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ARG B 394
TYR B 421
GLN B 423
TYR B 333
 None
 1.29A 1nx9A-5y3rB:
undetectable		 1nx9A-5y3rB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ARG B 394
TYR B 421
GLN B 423
TYR B 333
 None
 1.31A 1nx9B-5y3rB:
2.4		 1nx9B-5y3rB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ARG B 394
TYR B 421
GLN B 423
TYR B 333
 None
 1.28A 1nx9C-5y3rB:
undetectable		 1nx9C-5y3rB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ARG B 394
TYR B 421
GLN B 423
TYR B 333
 None
 1.29A 1nx9D-5y3rB:
2.4		 1nx9D-5y3rB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C  66
LEU C  65
GLY C  64
ARG C  24
THR C 137
 None
 1.46A 1p93A-5y3rC:
undetectable		 1p93A-5y3rC:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 LEU C 862
TRP C 776
LEU C 793
GLN C 786
 None
 1.44A 1p93D-5y3rC:
undetectable		 1p93D-5y3rC:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C2451
TYR C2474
LEU C2477
TYR C2440
TYR C2484
 None
 1.44A 1pj7A-5y3rC:
undetectable		 1pj7A-5y3rC:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		5 / 10 TYR A  71
ASP A 109
ARG A 115
LEU A 119
ILE A  39
 None
 1.20A 1q6iB-5y3rA:
undetectable		 1q6iB-5y3rA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C1915
LEU C1918
CYH C1919
ALA C1922
GLU C1925
 None
 0.42A 1s9pC-5y3rC:
undetectable		 1s9pC-5y3rC:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 LYS C4070
GLU C4069
ALA C4073
LEU C3857
 None
 1.16A 1sn5A-5y3rC:
undetectable		 1sn5A-5y3rC:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ALA C2796
ARG C2538
ASN C2560
GLU C2564
 None
 1.28A 1t9wA-5y3rC:
undetectable		 1t9wA-5y3rC:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 LYS C 681
ALA C 677
LEU C 743
THR C 673
 None
 1.34A 1tyrA-5y3rC:
undetectable		 1tyrA-5y3rC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 6 ILE B 267
VAL B 342
ILE B 261
ILE B 253
 None
 0.78A 1uwhA-5y3rB:
undetectable		 1uwhA-5y3rB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 LEU C 793
LEU C 796
LEU C 859
LEU C 862
 None
 1.05A 2ab2B-5y3rC:
undetectable		 2ab2B-5y3rC:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A  94
ASP A 109
ASP B 319
 None
 1.03A 2br4A-5y3rA:
undetectable		 2br4A-5y3rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 4 LEU A 119
SER A  73
ASP A 109
ASP A 156
 None
 1.21A 2br4B-5y3rA:
2.2		 2br4B-5y3rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 ALA C3987
ALA C3990
ALA C3780
SER C3906
LEU C3910
 None
 0.99A 2bxgB-5y3rC:
undetectable		 2bxgB-5y3rC:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A 495
GLU A 491
LEU A 243
SER A  69
VAL A  70
 None
 1.16A 2c12C-5y3rA:
undetectable		 2c12C-5y3rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TRP C4013
LYS C4019
PRO C4009
 None
 1.45A 2dqyB-5y3rC:
undetectable		 2dqyB-5y3rC:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ARG C  70
GLU C  80
PRO C 126
ALA C 127
 None
 1.36A 2ejgB-5y3rC:
undetectable		 2ejgB-5y3rC:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C3254
ALA C3246
ILE C3243
ALA C3006
PHE C3252
 None
 0.95A 2ejtA-5y3rC:
undetectable		 2ejtA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 PHE C3887
ARG C2891
SER C3891
ARG C3901
 None
 1.16A 2f7fA-5y3rC:
undetectable		 2f7fA-5y3rC:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		5 / 12 PHE B 426
ASN A 480
GLY B 406
VAL A 277
ASP B 429
 None
 1.35A 2fqyA-5y3rB:
5.2		 2fqyA-5y3rB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C3336
ALA C3349
LEU C3341
SER C3342
LEU C3301
 None
 0.95A 2h79A-5y3rC:
undetectable		 2h79A-5y3rC:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 PRO C 986
LEU C 970
ARG C1034
GLY C1030
 None
 1.18A 2hs2B-5y3rC:
undetectable		 2hs2B-5y3rC:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C1135
CYH C1176
HIS C1175
 None
 0.78A 2iwkA-5y3rC:
undetectable		 2iwkA-5y3rC:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C1135
CYH C1176
HIS C1175
 None
 0.80A 2iwkB-5y3rC:
undetectable		 2iwkB-5y3rC:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 6 LEU A 239
PHE A 169
ILE A  67
VAL A  70
 None
 1.09A 2j5mA-5y3rA:
undetectable		 2j5mA-5y3rA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C 758
LEU C 765
ALA C 766
LEU C 725
THR C 731
 None
 1.19A 2oaxB-5y3rC:
undetectable		 2oaxB-5y3rC:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C1601
LEU C1695
ALA C1692
LEU C1710
LEU C1684
 None
 1.30A 2oaxD-5y3rC:
undetectable		 2oaxD-5y3rC:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C1601
LEU C1695
ALA C1692
LEU C1710
LEU C1684
 None
 1.38A 2oaxE-5y3rC:
undetectable		 2oaxE-5y3rC:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
 None
 1.22A 2ocfA-5y3rC:
undetectable		 2ocfA-5y3rC:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 TYR C 408
GLN C 399
TYR C 366
ILE C 363
 None
 1.21A 2ph9A-5y3rC:
undetectable
2ph9B-5y3rC:
undetectable		 2ph9A-5y3rC:
4.74
2ph9B-5y3rC:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PHE C3967
LEU C3970
MET C3971
LEU C3900
VAL C3937
 None
 1.21A 2po5A-5y3rC:
undetectable		 2po5A-5y3rC:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 PHE C3967
LEU C3970
MET C3971
LEU C3900
VAL C3937
 None
 1.20A 2po5B-5y3rC:
undetectable		 2po5B-5y3rC:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 MET C1724
ILE C1655
PRO C 433
SER C1813
 None
 1.23A 2qd3B-5y3rC:
undetectable		 2qd3B-5y3rC:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ARG C  82
ARG C  79
PHE C  78
ILE C  76
 None
 1.10A 2qeiA-5y3rC:
undetectable		 2qeiA-5y3rC:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 ARG C  70
ASP C  23
ALA C  27
ILE C  85
 None
 1.07A 2qhfA-5y3rC:
undetectable		 2qhfA-5y3rC:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		3 / 3 ARG B 502
ARG B 497
PRO B 501
 None
 1.05A 2wljA-5y3rB:
undetectable		 2wljA-5y3rB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 VAL C3726
ARG C3630
TRP C3686
THR C3635
 None
 1.45A 2x2iA-5y3rC:
undetectable		 2x2iA-5y3rC:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 SER C3579
ARG C3734
PRO C3677
GLY C3678
 None
 1.23A 2y7kB-5y3rC:
undetectable		 2y7kB-5y3rC:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 MET C2473
ASP C2437
VAL C2459
TYR C2474
 None
 1.11A 2yfbA-5y3rC:
undetectable		 2yfbA-5y3rC:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TYR C3791
VAL C3764
THR C3790
 None
 0.81A 2ygnA-5y3rC:
undetectable		 2ygnA-5y3rC:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 8 ALA A 494
TYR B 316
ILE A  72
TYR A  71
 None
 0.95A 2zm8A-5y3rA:
undetectable		 2zm8A-5y3rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 8 ALA A 494
TYR B 316
ILE A  72
TYR A  71
 None
 0.95A 2zmaA-5y3rA:
undetectable		 2zmaA-5y3rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ASN B 440
PHE A 382
GLY A 377
ILE A 269
PHE A 432
 None
 1.24A 3a25A-5y3rB:
undetectable		 3a25A-5y3rB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 GLY C3566
SER C3537
ILE C3568
ASP C3563
 None
 0.94A 3a7eA-5y3rC:
undetectable		 3a7eA-5y3rC:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 LEU C1524
PHE C1519
PHE C1563
LEU C1562
 None
 1.02A 3abkP-5y3rC:
undetectable
3abkW-5y3rC:
undetectable		 3abkP-5y3rC:
5.03
3abkW-5y3rC:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 MET C3959
ILE C4116
PHE C3961
LEU C3970
GLU C2904
 None
 1.39A 3aocC-5y3rC:
undetectable		 3aocC-5y3rC:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 VAL C1373
VAL C1371
THR C1417
THR C1375
 None
 1.27A 3bjwG-5y3rC:
undetectable		 3bjwG-5y3rC:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 VAL C 483
VAL C 482
PHE C 551
ARG C1806
 None
 1.03A 3bjwB-5y3rC:
undetectable		 3bjwB-5y3rC:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C 703
PHE C 707
PHE C 704
 None
 0.90A 3cr5X-5y3rC:
undetectable		 3cr5X-5y3rC:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C1135
CYH C1176
HIS C1175
 None
 0.72A 3dtuB-5y3rC:
undetectable		 3dtuB-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C1135
CYH C1176
HIS C1175
 None
 0.70A 3dtuD-5y3rC:
undetectable		 3dtuD-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 4 ILE B 150
GLN B  73
ILE B 134
LEU B  68
 None
 1.31A 3dzyD-5y3rB:
undetectable		 3dzyD-5y3rB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 5 ASP B 398
ARG B 250
ILE B 261
VAL B 393
 None
 1.20A 3eigA-5y3rB:
undetectable		 3eigA-5y3rB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 ALA C3349
LEU C3377
GLU C3352
VAL C3297
ILE C3336
 None
 1.34A 3fl9D-5y3rC:
undetectable		 3fl9D-5y3rC:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ARG C 746
GLU C 713
ASP C1388
 None
 0.81A 3g2oA-5y3rC:
undetectable		 3g2oA-5y3rC:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2046
GLN C2042
PHE C2045
 None
 0.67A 3g4lC-5y3rC:
undetectable		 3g4lC-5y3rC:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C2248
PRO C2252
ASP C2208
 None
 0.87A 3hlwB-5y3rC:
undetectable		 3hlwB-5y3rC:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
 None
 1.18A 3hm1B-5y3rC:
undetectable		 3hm1B-5y3rC:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LYS C1141
ILE C1271
PHE C1270
 None
 0.86A 3j7zS-5y3rC:
undetectable
3j7za-5y3rC:
undetectable		 3j7zS-5y3rC:
2.56
3j7za-5y3rC:
0.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 PHE C1978
TYR C2030
LEU C1934
 None
 0.66A 3keeB-5y3rC:
undetectable		 3keeB-5y3rC:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.12A 3ko0A-5y3rB:
undetectable
3ko0B-5y3rB:
undetectable
3ko0C-5y3rB:
undetectable
3ko0D-5y3rB:
undetectable		 3ko0A-5y3rB:
11.39
3ko0B-5y3rB:
11.39
3ko0C-5y3rB:
11.39
3ko0D-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 ASP B  72
SER B 145
ILE B 150
LEU B 111
ASP B 109
 None
 1.07A 3ko0G-5y3rB:
undetectable
3ko0H-5y3rB:
undetectable
3ko0I-5y3rB:
undetectable
3ko0J-5y3rB:
undetectable		 3ko0G-5y3rB:
11.39
3ko0H-5y3rB:
11.39
3ko0I-5y3rB:
11.39
3ko0J-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ASP B  72
LEU B 111
ASP B 109
SER B 145
ILE B 150
 None
 1.08A 3ko0A-5y3rB:
undetectable
3ko0B-5y3rB:
undetectable
3ko0I-5y3rB:
undetectable
3ko0J-5y3rB:
undetectable		 3ko0A-5y3rB:
11.39
3ko0B-5y3rB:
11.39
3ko0I-5y3rB:
11.39
3ko0J-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.09A 3ko0K-5y3rB:
undetectable
3ko0L-5y3rB:
undetectable
3ko0S-5y3rB:
undetectable
3ko0T-5y3rB:
undetectable		 3ko0K-5y3rB:
11.39
3ko0L-5y3rB:
11.39
3ko0S-5y3rB:
11.39
3ko0T-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU B 111
ASP B 109
SER B 145
ILE B 150
ASP B  72
 None
 1.13A 3ko0K-5y3rB:
undetectable
3ko0L-5y3rB:
undetectable
3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable		 3ko0K-5y3rB:
11.39
3ko0L-5y3rB:
11.39
3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 SER B 145
ILE B 150
LEU B 111
ASP B 109
ASP B  72
 None
 1.12A 3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable
3ko0O-5y3rB:
undetectable
3ko0P-5y3rB:
undetectable		 3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
3ko0O-5y3rB:
11.39
3ko0P-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 ASP B  72
LEU B 111
ASP B 109
SER B 145
ILE B 150
 None
 1.10A 3ko0M-5y3rB:
undetectable
3ko0N-5y3rB:
undetectable
3ko0O-5y3rB:
undetectable
3ko0P-5y3rB:
undetectable		 3ko0M-5y3rB:
11.39
3ko0N-5y3rB:
11.39
3ko0O-5y3rB:
11.39
3ko0P-5y3rB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ARG C3467
ASP C3418
GLN C3777
 None
 0.94A 3lcvB-5y3rC:
undetectable		 3lcvB-5y3rC:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 ASP B  72
SER B 145
LEU B 111
ASP B 109
 None
 0.91A 3m0wE-5y3rB:
undetectable
3m0wF-5y3rB:
undetectable
3m0wG-5y3rB:
undetectable
3m0wH-5y3rB:
undetectable		 3m0wE-5y3rB:
11.45
3m0wF-5y3rB:
11.45
3m0wG-5y3rB:
11.45
3m0wH-5y3rB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 10 LEU B 111
ASP B 109
SER B 145
ILE B 150
ASP B  72
 None
 1.12A 3m0wE-5y3rB:
undetectable
3m0wF-5y3rB:
undetectable
3m0wG-5y3rB:
undetectable
3m0wH-5y3rB:
undetectable		 3m0wE-5y3rB:
11.45
3m0wF-5y3rB:
11.45
3m0wG-5y3rB:
11.45
3m0wH-5y3rB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 10 LEU B 111
ASP B 109
SER B 145
ILE B 150
ASP B  72
 None
 1.13A 3m0wA-5y3rB:
undetectable
3m0wB-5y3rB:
undetectable
3m0wI-5y3rB:
undetectable
3m0wJ-5y3rB:
undetectable		 3m0wA-5y3rB:
11.45
3m0wB-5y3rB:
11.45
3m0wI-5y3rB:
11.45
3m0wJ-5y3rB:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 PHE C1082
ILE C1138
ARG C1090
TYR C1107
LEU C1153
 None
 1.47A 3m7rA-5y3rC:
undetectable		 3m7rA-5y3rC:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 LEU C1254
VAL C1337
LEU C1242
ILE C1301
ALA C1302
 None
 1.08A 3mdvA-5y3rC:
undetectable		 3mdvA-5y3rC:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LYS C3257
ARG C2962
ASP C3181
 None
 1.42A 3o7wA-5y3rC:
undetectable		 3o7wA-5y3rC:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 VAL C2458
ILE C2476
MET C2408
ARG C2452
 None
 1.27A 3oezA-5y3rC:
undetectable		 3oezA-5y3rC:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ALA C1293
VAL C1294
GLN C1238
 None
 0.74A 3of4B-5y3rC:
undetectable		 3of4B-5y3rC:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 GLU C1930
PRO C1991
ARG C1987
GLY C1929
 None
 1.11A 3oxvA-5y3rC:
undetectable		 3oxvA-5y3rC:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 7 PHE B 426
ASP A 505
ILE B 392
TYR B 421
 None
 1.08A 3p6hA-5y3rB:
undetectable		 3p6hA-5y3rB:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 LEU C1484
GLY C1480
LEU C1483
GLU C1482
 None
 1.10A 3tgvB-5y3rC:
undetectable		 3tgvB-5y3rC:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 5 ILE B 482
PRO B 483
SER B 230
LYS B 233
 None
 1.19A 3tkdB-5y3rB:
undetectable		 3tkdB-5y3rB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LYS C 124
ARG C  70
LEU C 130
 None
 1.39A 3v4tE-5y3rC:
undetectable		 3v4tE-5y3rC:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ALA C1012
ILE C1013
ARG C1075
GLY C1016
 None
 0.94A 3v4tH-5y3rC:
undetectable		 3v4tH-5y3rC:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 TYR C3013
THR C2949
ILE C2952
SER C2955
ALA C3017
 None
 1.26A 3vw1B-5y3rC:
undetectable		 3vw1B-5y3rC:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 ILE B 412
LEU B 362
ALA B 391
LEU B 251
VAL B 342
 None
 1.17A 3w67C-5y3rB:
2.4		 3w67C-5y3rB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 THR C 965
TYR C 984
ARG C 964
LEU C1009
 None
 1.22A 3wipG-5y3rC:
undetectable
3wipH-5y3rC:
undetectable		 3wipG-5y3rC:
4.75
3wipH-5y3rC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ARG C 964
LEU C1009
THR C 965
TYR C 984
 None
 1.19A 3wipF-5y3rC:
undetectable
3wipJ-5y3rC:
undetectable		 3wipF-5y3rC:
4.75
3wipJ-5y3rC:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 THR C3867
TRP C3842
ASN C4115
TYR C3839
 None
 1.34A 4a3uA-5y3rC:
undetectable		 4a3uA-5y3rC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 THR C3867
TRP C3842
ASN C4115
TYR C3839
 None
 1.34A 4a3uB-5y3rC:
undetectable		 4a3uB-5y3rC:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLN C3564
ARG C3696
GLY C3565
ALA C3574
MET C3796
 None
 1.23A 4a6nA-5y3rC:
undetectable		 4a6nA-5y3rC:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
 None
 1.44A 4a6nB-5y3rC:
undetectable		 4a6nB-5y3rC:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
 None
 1.44A 4a6nC-5y3rC:
undetectable		 4a6nC-5y3rC:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
 None
 1.44A 4a6nD-5y3rC:
undetectable		 4a6nD-5y3rC:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ARG C2842
ASP C2860
GLN C2859
 None
 0.91A 4azsA-5y3rC:
undetectable		 4azsA-5y3rC:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TYR C 788
MET C 785
ILE C 778
 None
 0.77A 4c8bB-5y3rC:
undetectable		 4c8bB-5y3rC:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C 316
SER C 314
ALA C 362
SER C 360
LEU C 359
 None
 1.10A 4coxC-5y3rC:
undetectable		 4coxC-5y3rC:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY B  70
GLY B  71
ASN B  76
LEU B  58
GLY B  60
 None
 1.07A 4fp9C-5y3rB:
undetectable		 4fp9C-5y3rB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 ASN C2217
LEU C2219
MET C2220
SER C2250
ASP C2208
 None
 1.23A 4fr8A-5y3rC:
undetectable		 4fr8A-5y3rC:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 LEU C 773
TRP C 776
ILE C 792
ASN C 869
 None
 1.30A 4i00A-5y3rC:
undetectable		 4i00A-5y3rC:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 LYS C 681
ALA C 677
SER C 671
THR C 673
 None
 1.25A 4i89B-5y3rC:
undetectable		 4i89B-5y3rC:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens) 		4 / 8 VAL B  57
ASN B  66
PRO B  67
GLN B  73
 None
 1.06A 4iilA-5y3rB:
6.0		 4iilA-5y3rB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ALA C 804
SER C 803
LEU C 859
ARG C3125
 None
 1.11A 4ijiF-5y3rC:
undetectable		 4ijiF-5y3rC:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASN C4055
ALA C4057
LEU C4107
ARG C4090
 None
 1.00A 4ijiF-5y3rC:
undetectable		 4ijiF-5y3rC:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 SER C 803
LYS C 868
LEU C 793
LEU C 796
 None
 0.94A 4iklA-5y3rC:
undetectable
4iklB-5y3rC:
undetectable		 4iklA-5y3rC:
2.74
4iklB-5y3rC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PHE B 435
TYR A 369
THR A 428
PHE A 367
 None
 0.79A 4jx1E-5y3rB:
undetectable		 4jx1E-5y3rB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.73A 4k8cA-5y3rC:
undetectable		 4k8cA-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.72A 4kahA-5y3rC:
undetectable		 4kahA-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.73A 4kahB-5y3rC:
undetectable		 4kahB-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.72A 4kanA-5y3rC:
undetectable		 4kanA-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.75A 4kanB-5y3rC:
undetectable		 4kanB-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.77A 4kbeA-5y3rC:
undetectable		 4kbeA-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.75A 4kbeB-5y3rC:
undetectable		 4kbeB-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA C 120
ASP B 299
SER C  72
LEU C  66
VAL C 114
 None
 1.29A 4kyaB-5y3rC:
undetectable		 4kyaB-5y3rC:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA C 120
ASP B 299
SER C  72
LEU C  66
VAL C 114
 None
 1.29A 4kyaD-5y3rC:
undetectable		 4kyaD-5y3rC:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA C 120
ASP B 299
SER C  72
LEU C  66
VAL C 114
 None
 1.30A 4kyaF-5y3rC:
undetectable		 4kyaF-5y3rC:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA C 120
ASP B 299
SER C  72
LEU C  66
VAL C 114
 None
 1.24A 4kyaH-5y3rC:
undetectable		 4kyaH-5y3rC:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.74A 4lbgA-5y3rC:
undetectable		 4lbgA-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C2051
TYR C2004
PRO C2061
 None
 0.71A 4lbgB-5y3rC:
undetectable		 4lbgB-5y3rC:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LEU C1915
LYS C1913
THR C1914
 None
 0.60A 4lj0A-5y3rC:
undetectable		 4lj0A-5y3rC:
1.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 ALA C  27
HIS C  32
PHE C  78
LEU C  34
 None
 1.20A 4luhA-5y3rC:
undetectable		 4luhA-5y3rC:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 SER C 728
ASP C1022
ASP C1015
 None
 0.86A 4mwzA-5y3rC:
undetectable		 4mwzA-5y3rC:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C1260
LEU C1264
GLN C1231
LEU C1291
THR C1253
 None
 1.33A 4olmA-5y3rC:
undetectable		 4olmA-5y3rC:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 LEU C 320
SER C 324
VAL C 291
LEU C 287
LEU C 316
 None
 1.22A 4or0B-5y3rC:
undetectable		 4or0B-5y3rC:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 CYH C2248
PRO C2252
ASP C2208
 None
 0.84A 4pm5A-5y3rC:
undetectable		 4pm5A-5y3rC:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ASP C3587
LYS C4019
LEU C3758
 None
 0.83A 4ptjA-5y3rC:
undetectable		 4ptjA-5y3rC:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 GLN C2954
LEU C2957
SER C2955
ASP C2992
 None
 1.21A 4qtuD-5y3rC:
undetectable		 4qtuD-5y3rC:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		3 / 3 TYR B 316
GLY A 112
PRO A 111
 None
 0.71A 4qwpA-5y3rB:
undetectable		 4qwpA-5y3rB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 PHE C1028
THR C 996
LEU C1059
 None
 0.72A 4qztA-5y3rC:
undetectable		 4qztA-5y3rC:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLU C1760
LEU C1939
LEU C1752
GLU C1993
PHE C1900
 None
 1.19A 4retC-5y3rC:
undetectable		 4retC-5y3rC:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		6 / 12 LEU C 316
SER C 314
LEU C 368
ALA C 362
SER C 360
LEU C 359
 None
 1.33A 4rrwD-5y3rC:
undetectable		 4rrwD-5y3rC:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		6 / 12 LEU C 316
SER C 314
LEU C 368
ALA C 362
SER C 360
LEU C 359
 None
 1.33A 4rrzD-5y3rC:
undetectable		 4rrzD-5y3rC:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 7 LEU A 381
SER A 378
ILE A 269
VAL A 271
 None
 0.84A 4tvtA-5y3rA:
undetectable		 4tvtA-5y3rA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 LEU C 662
GLY C 769
LEU C 773
GLU C 775
SER C 735
 None
 1.34A 4wnuC-5y3rC:
undetectable		 4wnuC-5y3rC:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		3 / 3 LYS A 338
ARG C 213
VAL C 212
 None
 0.72A 4x3uA-5y3rA:
undetectable
4x3uB-5y3rA:
undetectable		 4x3uA-5y3rA:
8.08
4x3uB-5y3rA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C2219
GLY C2181
GLY C2179
LEU C2083
LEU C2171
 None
 1.19A 4x61A-5y3rC:
undetectable		 4x61A-5y3rC:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PRO C3735
ASP C3814
THR C3811
MET C3929
ASP C3941
 None
 1.42A 4xe0A-5y3rC:
undetectable		 4xe0A-5y3rC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 PRO C3735
ILE C3803
THR C3809
ILE C3940
ASP C3941
 None
 1.41A 4xe0A-5y3rC:
undetectable		 4xe0A-5y3rC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 7 ARG C 213
SER C 210
GLU A 333
GLU A 332
 None
 1.22A 4xzkA-5y3rC:
undetectable		 4xzkA-5y3rC:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 6 LEU A  38
ASP A  81
LEU A 108
ILE A  67
 None
 1.13A 4y4dA-5y3rA:
undetectable		 4y4dA-5y3rA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLY C3921
ASP C3941
HIS C3908
CYH C3912
ILE C3911
 None
 1.49A 4ypaA-5y3rC:
undetectable		 4ypaA-5y3rC:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE C1124
GLN C1125
ILE C1131
ASP C1132
 None
 0.94A 4z4cA-5y3rC:
undetectable		 4z4cA-5y3rC:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LYS C2227
ARG C2228
HIS C2225
 None
 1.16A 4zbrA-5y3rC:
undetectable		 4zbrA-5y3rC:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
 None
 1.23A 4zn7B-5y3rC:
undetectable		 4zn7B-5y3rC:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 4 VAL A  86
ILE A 166
ASN A 152
VAL A 146
 None
 1.34A 5ajqA-5y3rA:
undetectable		 5ajqA-5y3rA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ASP C2429
ARG C  36
GLY C  31
GLU C  84
 None
 0.94A 5btaA-5y3rC:
undetectable
5btaC-5y3rC:
undetectable
5btaD-5y3rC:
undetectable		 5btaA-5y3rC:
8.19
5btaC-5y3rC:
8.19
5btaD-5y3rC:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 MET C3858
LEU C3958
MET C3959
ARG C4090
 None
 1.16A 5dxeA-5y3rC:
undetectable		 5dxeA-5y3rC:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 ALA C3513
HIS C3516
MET C3502
LEU C3469
 None
 1.49A 5dzkb-5y3rC:
undetectable
5dzkp-5y3rC:
undetectable		 5dzkb-5y3rC:
4.07
5dzkp-5y3rC:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		5 / 9 VAL A  42
PHE A  60
ILE A  64
PHE A 122
LEU A 105
 None
 1.20A 5e4dA-5y3rA:
undetectable		 5e4dA-5y3rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 PRO C 897
LEU C2563
SER C2789
 None
 0.83A 5fsaB-5y3rC:
undetectable		 5fsaB-5y3rC:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 GLY C3618
ASP C3641
ARG C3629
MET C3796
 None
 1.38A 5gwkB-5y3rC:
undetectable		 5gwkB-5y3rC:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 GLY C1226
PRO C1158
THR C1223
GLN C1231
 None
 1.26A 5h5fA-5y3rC:
undetectable		 5h5fA-5y3rC:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 CYH C1128
ILE C1124
LEU C1111
ALA C1114
 None
 0.92A 5hrqE-5y3rC:
undetectable
5hrqF-5y3rC:
undetectable
5hrqJ-5y3rC:
undetectable		 5hrqE-5y3rC:
0.64
5hrqF-5y3rC:
0.84
5hrqJ-5y3rC:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ILE C 741
LEU C 734
ALA C 715
HIS C 738
 None
 0.99A 5hrqE-5y3rC:
undetectable
5hrqF-5y3rC:
undetectable
5hrqJ-5y3rC:
undetectable		 5hrqE-5y3rC:
0.64
5hrqF-5y3rC:
0.84
5hrqJ-5y3rC:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU C 316
SER C 314
ALA C 362
SER C 360
LEU C 359
 None
 0.99A 5ikrA-5y3rC:
undetectable		 5ikrA-5y3rC:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 SER C3432
ASP C3435
PHE C3382
ASN C3430
 None
 1.21A 5l1fC-5y3rC:
undetectable		 5l1fC-5y3rC:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU C 230
ALA C 199
SER A 314
PHE C 200
LEU C 162
 None
 1.08A 5nd2B-5y3rC:
undetectable		 5nd2B-5y3rC:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLY A 191
ARG A 218
ASP A 192
GLN C2353
 None
 1.50A 5ubbA-5y3rA:
undetectable		 5ubbA-5y3rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TRP C2245
MET C2220
ASN C2217
 None
 1.45A 5uc1B-5y3rC:
undetectable		 5uc1B-5y3rC:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 TRP C2245
MET C2220
ASN C2217
 None
 1.45A 5uc1A-5y3rC:
undetectable		 5uc1A-5y3rC:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 LEU C1524
PHE C1519
PHE C1563
LEU C1562
 None
 0.99A 5x1bP-5y3rC:
undetectable		 5x1bP-5y3rC:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6
(Homo
sapiens) 		4 / 6 TYR C 175
LEU C 196
GLU C 203
LEU A 312
 None
 1.40A 5xooA-5y3rC:
undetectable		 5xooA-5y3rC:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 GLY C 594
ARG C1087
ASN C 593
LEU C1080
 None
 1.20A 6b58A-5y3rC:
undetectable		 6b58A-5y3rC:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLU C1354
PHE C1270
GLN C1280
PHE C1296
ILE C1341
 None
 1.34A 6becA-5y3rC:
undetectable
6becB-5y3rC:
undetectable
6becC-5y3rC:
undetectable		 6becA-5y3rC:
9.18
6becB-5y3rC:
9.18
6becC-5y3rC:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 SER C1657
ALA C1680
SER C1677
ALA C1650
 None
 1.03A 6bocA-5y3rC:
undetectable
6bocB-5y3rC:
undetectable
6bocC-5y3rC:
undetectable
6bocD-5y3rC:
undetectable		 6bocA-5y3rC:
0.99
6bocB-5y3rC:
0.99
6bocC-5y3rC:
0.99
6bocD-5y3rC:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 MET C3858
LEU C3958
MET C3959
ARG C4090
 None
 1.14A 6cbzA-5y3rC:
undetectable		 6cbzA-5y3rC:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ASP C2964
GLN C3291
GLU C2960
ALA C3255
 None
 1.18A 6djzB-5y3rC:
undetectable		 6djzB-5y3rC:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 PHE C3571
GLY C3566
ILE C3568
PHE C3722
ILE C3719
 None
 1.23A 6ebpB-5y3rC:
undetectable		 6ebpB-5y3rC:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE C2933
ARG C2922
PRO C2918
ASP C2937
ARG C3901
 None
 1.19A 6ekuA-5y3rC:
undetectable		 6ekuA-5y3rC:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 THR C1346
ALA C1405
LYS C1407
 None
 0.62A 6fgcA-5y3rC:
undetectable		 6fgcA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 THR C1346
ALA C1405
LYS C1407
 None
 0.63A 6fgdA-5y3rC:
undetectable		 6fgdA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 LYS C1671
SER C1677
SER C1658
 None
 0.94A 6gbfA-5y3rC:
undetectable		 6gbfA-5y3rC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLY C3921
ASP C3941
HIS C3908
CYH C3912
ILE C3911
 None
 1.49A 6ineA-5y3rC:
undetectable		 6ineA-5y3rC:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 ARG C 391
LEU C 368
PHE C 369
PHE C 383
 None
 1.32A 6nmpP-5y3rC:
undetectable
6nmpW-5y3rC:
undetectable		 6nmpP-5y3rC:
5.03
6nmpW-5y3rC:
1.69