SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GEH_A_NHYA300_1 (CARBONIC ANHYDRASE 2)	5y3s	- (-)	4 / 8	HIS A 822 VAL A 825 LEU A 849 THR A 850	None	0.75A	2gehA-5y3sA: undetectable	2gehA-5y3sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IT4_A_PPFA500_1 (CARBONIC ANHYDRASE 1)	5y3s	- (-)	4 / 8	HIS A 822 ALA A 824 LEU A 849 THR A 850	None	0.88A	2it4A-5y3sA: undetectable	2it4A-5y3sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LM8_B_VIBB223_1 (THIAMINE PYROPHOSPHOKINASE)	5y3s	- (-)	4 / 7	LEU A 800 LEU A 813 SER A 816 ASN A 818	None	1.02A	3lm8B-5y3sA: undetectable 3lm8D-5y3sA: undetectable	3lm8B-5y3sA: undetectable 3lm8D-5y3sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G5G_B_ACTB1321_0 (PUTATIVE XANTHINE DEHYDROGENASE YAGR MOLYBDENUM-BINDING SU SUBUNIT)	5y3s	- (-)	3 / 3	THR A 793 ASP A 794 ALA A 795	None	0.09A	5g5gB-5y3sA: undetectable	5g5gB-5y3sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5PHH_A_LDPA414_1 (LYSINE-SPECIFIC DEMETHYLASE 4D)	5y3s	- (-)	4 / 6	GLU A 970 ARG A 947 ALA A 973 LEU A 971	None	1.15A	5phhA-5y3sA: undetectable	5phhA-5y3sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_B_SUEB1202_1 (NS3 PROTEASE)	5y3s	- (-)	5 / 9	LEU A 942 ALA A 915 VAL A 917 SER A 919 ASP A 913	None None None None PO4 A1001 (-3.9A)	1.36A	6c2mB-5y3sA: undetectable	6c2mB-5y3sA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2GEH_A_NHYA300_1","CARBONIC ANHYDRASE 2","5y3s","-","-",4,"HIS A 822;VAL A 825;LEU A 849;THR A 850","None","0.75A","2gehA-5y3sA:undetectable","2gehA-5y3sA:undetectable"],["2IT4_A_PPFA500_1","CARBONIC ANHYDRASE 1","5y3s","-","-",4,"HIS A 822;ALA A 824;LEU A 849;THR A 850","None","0.88A","2it4A-5y3sA:undetectable","2it4A-5y3sA:undetectable"],["3LM8_B_VIBB223_1","THIAMINE PYROPHOSPHOKINASE;THIAMINE PYROPHOSPHOKINASE","5y3s","-","-",4,"LEU A 800;LEU A 813;SER A 816;ASN A 818","None","1.02A","3lm8B-5y3sA:undetectable;3lm8D-5y3sA:undetectable","3lm8B-5y3sA:undetectable;3lm8D-5y3sA:undetectable"],["5G5G_B_ACTB1321_0","PUTATIVE XANTHINE DEHYDROGENASE YAGR MOLYBDENUM-BINDING SU SUBUNIT","5y3s","-","-",3,"THR A 793;ASP A 794;ALA A 795","None","0.09A","5g5gB-5y3sA:undetectable","5g5gB-5y3sA:undetectable"],["5PHH_A_LDPA414_1","LYSINE-SPECIFIC DEMETHYLASE 4D","5y3s","-","-",4,"GLU A 970;ARG A 947;ALA A 973;LEU A 971","None","1.15A","5phhA-5y3sA:undetectable","5phhA-5y3sA:undetectable"],["6C2M_B_SUEB1202_1","NS3 PROTEASE","5y3s","-","-",5,"LEU A 942;ALA A 915;VAL A 917;SER A 919;ASP A 913","None;None;None;None;PO4 A1001 (-3.9A)","1.36A","6c2mB-5y3sA:undetectable","6c2mB-5y3sA:undetectable"]]