SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		5 / 12 VAL B 486
LEU C 229
GLY B 482
SER C 231
PHE C 293
 None
 1.03A 1fdsA-5y3tB:
undetectable		 1fdsA-5y3tB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		5 / 12 VAL B 486
LEU C 229
GLY B 482
SER C 231
PHE C 293
 None
 1.07A 1fduC-5y3tB:
undetectable		 1fduC-5y3tB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_B_ESTB600_1
(OESTROGEN RECEPTOR)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 9 LEU A  13
ALA A  12
GLU A   9
LEU C 206
MET C 207
 None
 1.27A 1gwrB-5y3tA:
undetectable		 1gwrB-5y3tA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		4 / 8 ARG B 479
SER C 233
ASP B 476
LYS B 473
 None
 1.21A 1hwiB-5y3tB:
undetectable		 1hwiB-5y3tB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		4 / 8 ARG B 479
SER C 233
ASP B 476
LYS B 473
 None
 1.09A 1hwkA-5y3tB:
undetectable		 1hwkA-5y3tB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		4 / 8 ARG B 479
SER C 233
ASP B 476
LYS B 473
 None
 1.13A 1hwkC-5y3tB:
undetectable		 1hwkC-5y3tB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		4 / 8 ARG B 479
SER C 233
ASP B 476
LYS B 473
 None
 1.15A 1hwkD-5y3tB:
undetectable		 1hwkD-5y3tB:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 12 GLU B 561
GLN B 507
ARG B 555
GLU A  10
TYR C 283
 None
 1.48A 2a7qA-5y3tB:
undetectable		 2a7qA-5y3tB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5y3t SHARPIN
(Mus
musculus) 		4 / 7 SER C 246
CYH C 245
GLN C 265
ILE C 241
 None
 1.22A 2xz5A-5y3tC:
undetectable
2xz5B-5y3tC:
undetectable		 2xz5A-5y3tC:
undetectable
2xz5B-5y3tC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 12 GLU B 561
GLN B 507
ARG B 555
GLU A  10
TYR C 283
 None
 1.44A 2ziaA-5y3tB:
undetectable		 2ziaA-5y3tB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Mus
musculus) 		4 / 6 ARG B 610
PHE B 614
PRO B 613
LEU B 611
 None
 1.31A 3tgvB-5y3tB:
undetectable		 3tgvB-5y3tB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Mus
musculus) 		4 / 5 ARG B 610
PHE B 614
PRO B 613
LEU B 611
 None
 1.41A 3tgvC-5y3tB:
undetectable		 3tgvC-5y3tB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
(Mus
musculus) 		4 / 5 VAL A  75
LEU A 114
ILE A 119
VAL A  59
 None
 0.98A 4a9kB-5y3tA:
undetectable		 4a9kB-5y3tA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 11 LEU C 206
SER A  14
LEU A  13
ARG C 278
SER C 282
 None
 1.22A 4zbqA-5y3tC:
undetectable		 4zbqA-5y3tC:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN
(Mus
musculus) 		4 / 7 SER C 279
ARG C 271
GLY C 270
GLU B 481
 None
 1.14A 5btfA-5y3tC:
undetectable
5btfC-5y3tC:
undetectable
5btfD-5y3tC:
undetectable		 5btfA-5y3tC:
9.34
5btfC-5y3tC:
9.34
5btfD-5y3tC:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 11 LEU A  13
ALA A  12
GLU A   9
LEU C 206
MET C 207
 None
 1.26A 5dxgB-5y3tA:
undetectable		 5dxgB-5y3tA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 11 LEU A  13
ALA A  12
GLU A   9
LEU C 206
MET C 207
 None
 1.28A 5hyrB-5y3tA:
undetectable		 5hyrB-5y3tA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
(Mus
musculus) 		5 / 12 PHE B 503
GLY B 557
GLN B 507
SER B 509
LEU B 518
 None
 1.39A 5ji0D-5y3tB:
undetectable		 5ji0D-5y3tB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN
(Mus
musculus) 		5 / 10 LEU A  13
ALA A  12
GLU A   9
LEU C 206
MET C 207
 None
 1.23A 6cbzB-5y3tA:
undetectable		 6cbzB-5y3tA:
20.69