SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 GLU A 114
ILE A 169
ILE A 165
ARG A 117
GLU A 172
 None
 1.18A 1ki7A-5y3xA:
undetectable		 1ki7A-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 GLY A 298
PHE A 296
SER A 293
ILE A 299
LEU A  39
 None
 1.16A 1lhuA-5y3xA:
undetectable		 1lhuA-5y3xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		4 / 6 ASN A 182
HIS A  86
GLN A 244
THR A  47
 None
 1.24A 2hkkA-5y3xA:
undetectable		 2hkkA-5y3xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 GLU A 114
ILE A 169
ILE A 165
ARG A 117
GLU A 172
 None
 1.45A 2ki5A-5y3xA:
undetectable		 2ki5A-5y3xA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		4 / 6 LEU A 320
GLY A 298
LEU A  12
SER A  11
 None
 0.96A 3aiaA-5y3xA:
undetectable		 3aiaA-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 GLY A 298
ILE A  38
GLY A  36
LEU A 319
PRO A 318
 None
 1.20A 3eeyD-5y3xA:
undetectable		 3eeyD-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.71A 3jayA-5y3xA:
undetectable		 3jayA-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.66A 3jb2A-5y3xA:
undetectable		 3jb2A-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 3 ARG A 259
ASP A 316
ASP A 257
 None
 0.64A 3jb3A-5y3xA:
undetectable		 3jb3A-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 3 ASN A  92
ASN A 153
GLU A  96
 None
 0.71A 3kpdC-5y3xA:
undetectable		 3kpdC-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 3 ASN A  92
ASN A 153
GLU A  96
 None
 0.72A 3kpdB-5y3xA:
undetectable		 3kpdB-5y3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 10 ASN A  79
TYR A 127
ASP A  70
ASP A 129
ILE A  77
 None
 1.27A 3myuB-5y3xA:
undetectable		 3myuB-5y3xA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 GLY A 175
ALA A 174
VAL A 136
ILE A 120
PRO A 208
 None
 1.05A 3nu5B-5y3xA:
undetectable		 3nu5B-5y3xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		3 / 4 SER A  45
GLY A 213
GLU A 187
 None
 0.62A 4juoA-5y3xA:
undetectable
4juoC-5y3xA:
undetectable		 4juoA-5y3xA:
10.89
4juoC-5y3xA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 12 VAL A  28
ASP A  30
ALA A  68
GLN A  93
PRO A  48
 None
 1.30A 5syfB-5y3xA:
undetectable		 5syfB-5y3xA:
10.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5y3x BETA-XYLANASE
(Caldicellulosiru
ptor
owensensis) 		5 / 9 THR A 292
GLY A 211
ILE A 212
PHE A 180
ILE A 233
 None
 1.33A 6ebpA-5y3xA:
undetectable		 6ebpA-5y3xA:
40.91