SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 12 LEU A2483
ALA A2471
ILE A2411
MET A2414
ILE A2435
 None
None
SO4  A2702 (-3.8A)
None
None
 1.12A 1crbA-5y4dA:
undetectable		 1crbA-5y4dA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.08A 1fo4A-5y4dA:
undetectable		 1fo4A-5y4dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2336
THR A2381
VAL A2380
LEU A2383
ALA A2389
 None
 1.33A 1fo4A-5y4dA:
undetectable		 1fo4A-5y4dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2455
HIS A2436
LEU A2444
ALA A2439
LEU A2483
 None
None
SO4  A2703 (-4.5A)
None
None
 1.33A 1mjlA-5y4dA:
undetectable
1mjlB-5y4dA:
undetectable		 1mjlA-5y4dA:
10.65
1mjlB-5y4dA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 12 LEU A2333
SER A2334
PRO A2335
LEU A2300
GLY A2299
 None
 0.89A 1uakA-5y4dA:
undetectable		 1uakA-5y4dA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 8 SER A2646
ALA A2636
ALA A2669
LEU A2666
 None
 0.69A 2bxmA-5y4dA:
undetectable		 2bxmA-5y4dA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 7 THR A2160
ASP A2162
PRO A1624
LEU A2182
 None
 1.04A 2hdnE-5y4dA:
undetectable
2hdnF-5y4dA:
undetectable
2hdnH-5y4dA:
undetectable		 2hdnE-5y4dA:
6.50
2hdnF-5y4dA:
20.03
2hdnH-5y4dA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU A2182
THR A2160
ASP A2162
PRO A1624
 None
 1.05A 2hdnF-5y4dA:
undetectable
2hdnG-5y4dA:
undetectable
2hdnH-5y4dA:
undetectable		 2hdnF-5y4dA:
20.03
2hdnG-5y4dA:
6.50
2hdnH-5y4dA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 4 LEU A2270
PRO A2269
LEU A2285
ARG A2288
 None
 1.44A 2pnjB-5y4dA:
undetectable		 2pnjB-5y4dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO A2236
LEU A2252
ARG A2255
 None
 0.64A 3aqiB-5y4dA:
undetectable		 3aqiB-5y4dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO A2269
LEU A2285
ARG A2288
 None
 0.63A 3aqiB-5y4dA:
undetectable		 3aqiB-5y4dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO A2302
LEU A2318
ARG A2321
 None
 0.63A 3aqiB-5y4dA:
undetectable		 3aqiB-5y4dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2649
GLY A2652
SER A2621
PRO A2622
THR A2631
 None
 1.24A 3bjwB-5y4dA:
undetectable		 3bjwB-5y4dA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU A2336
SER A2334
ARG A2328
LEU A2351
 None
 1.19A 3onnA-5y4dA:
undetectable		 3onnA-5y4dA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 6 ASP A2204
LEU A2171
ALA A2180
LEU A2210
 None
 1.10A 3rozA-5y4dA:
undetectable		 3rozA-5y4dA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.11A 3unaA-5y4dA:
undetectable		 3unaA-5y4dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.08A 3unaB-5y4dA:
undetectable		 3unaB-5y4dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.11A 3uncA-5y4dA:
undetectable		 3uncA-5y4dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 9 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.11A 3uncB-5y4dA:
undetectable		 3uncB-5y4dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		3 / 3 LEU A2385
LYS A2382
THR A2381
 None
 0.53A 4lj0A-5y4dA:
undetectable		 4lj0A-5y4dA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 12 PRO A2599
VAL A2602
ALA A2603
TYR A2606
SER A2575
 None
 1.20A 4mmdB-5y4dA:
undetectable		 4mmdB-5y4dA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 12 ALA A2471
ALA A2439
GLN A2476
ALA A2474
ILE A2427
 None
 1.15A 4nqaH-5y4dA:
undetectable		 4nqaH-5y4dA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2171
ALA A2195
LEU A2211
VAL A2248
LEU A2252
 None
 1.12A 4p65C-5y4dA:
undetectable
4p65D-5y4dA:
undetectable
4p65J-5y4dA:
undetectable
4p65L-5y4dA:
undetectable		 4p65C-5y4dA:
4.95
4p65D-5y4dA:
4.26
4p65J-5y4dA:
4.26
4p65L-5y4dA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 None
 1.00A 4wg0B-5y4dA:
undetectable
4wg0C-5y4dA:
undetectable
4wg0D-5y4dA:
undetectable		 4wg0B-5y4dA:
1.38
4wg0C-5y4dA:
1.38
4wg0D-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 None
 0.99A 4wg0D-5y4dA:
undetectable
4wg0E-5y4dA:
undetectable
4wg0F-5y4dA:
undetectable		 4wg0D-5y4dA:
1.38
4wg0E-5y4dA:
1.38
4wg0F-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 None
 0.98A 4wg0F-5y4dA:
undetectable
4wg0G-5y4dA:
undetectable
4wg0H-5y4dA:
undetectable		 4wg0F-5y4dA:
1.38
4wg0G-5y4dA:
1.38
4wg0H-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 None
 0.96A 4wg0H-5y4dA:
undetectable
4wg0I-5y4dA:
undetectable
4wg0J-5y4dA:
undetectable		 4wg0H-5y4dA:
1.38
4wg0I-5y4dA:
1.38
4wg0J-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2195
LEU A2196
LEU A2212
LEU A2251
LEU A2252
 None
 0.98A 4wg0G-5y4dA:
undetectable
4wg0H-5y4dA:
undetectable
4wg0I-5y4dA:
undetectable		 4wg0G-5y4dA:
1.38
4wg0H-5y4dA:
1.38
4wg0I-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 LEU A2251
LEU A2252
LEU A2212
ALA A2195
LEU A2196
 None
 0.93A 4wg0J-5y4dA:
undetectable
4wg0K-5y4dA:
undetectable
4wg0L-5y4dA:
undetectable		 4wg0J-5y4dA:
1.38
4wg0K-5y4dA:
1.38
4wg0L-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2195
LEU A2196
LEU A2212
LEU A2251
LEU A2252
 None
 0.92A 4wg0I-5y4dA:
undetectable
4wg0J-5y4dA:
undetectable
4wg0K-5y4dA:
undetectable		 4wg0I-5y4dA:
1.38
4wg0J-5y4dA:
1.38
4wg0K-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		5 / 11 ALA A2195
LEU A2196
LEU A2212
LEU A2251
LEU A2252
 None
 0.96A 4wg0K-5y4dA:
undetectable
4wg0L-5y4dA:
undetectable
4wg0M-5y4dA:
undetectable		 4wg0K-5y4dA:
1.38
4wg0L-5y4dA:
1.38
4wg0M-5y4dA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 5 SER A2274
ALA A2273
MET A1615
LEU A2270
 None
 1.04A 5dzkf-5y4dA:
undetectable
5dzkt-5y4dA:
undetectable		 5dzkf-5y4dA:
14.73
5dzkt-5y4dA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 8 LEU A2182
LEU A2149
THR A2132
TYR A2135
 None
 1.08A 5hbsA-5y4dA:
undetectable		 5hbsA-5y4dA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		3 / 3 CYH A2406
LYS A2407
HIS A2443
 None
 1.21A 5js5A-5y4dA:
undetectable		 5js5A-5y4dA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU A2483
ALA A2488
THR A2433
ASN A2461
 None
 0.96A 6f88A-5y4dA:
undetectable		 6f88A-5y4dA:
7.80