SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 9 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.15A 1fo4A-5y4eA:
undetectable		 1fo4A-5y4eA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		4 / 4 TYR A 886
LEU A1396
LEU A1366
HIS A1374
 None
None
None
SO4  A1508 (-4.6A)
 1.46A 2x7hB-5y4eA:
undetectable		 2x7hB-5y4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		3 / 3 PRO A1302
LEU A1318
ARG A1321
 None
 0.65A 3aqiB-5y4eA:
undetectable		 3aqiB-5y4eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 12 ALA A1339
GLY A1310
SER A1309
ALA A1368
HIS A1377
 None
 1.27A 3ou7C-5y4eA:
undetectable		 3ou7C-5y4eA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 9 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.19A 3unaA-5y4eA:
undetectable		 3unaA-5y4eA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 9 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.15A 3unaB-5y4eA:
undetectable		 3unaB-5y4eA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 9 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.18A 3uncA-5y4eA:
undetectable		 3uncA-5y4eA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		5 / 9 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.18A 3uncB-5y4eA:
undetectable		 3uncB-5y4eA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		3 / 3 LEU A1385
LYS A1382
THR A1381
 None
 0.59A 4lj0A-5y4eA:
undetectable		 4lj0A-5y4eA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens) 		4 / 7 PHE A1399
ILE A1435
SER A1430
THR A1428
 None
 0.99A 5vkqA-5y4eA:
23.4
5vkqD-5y4eA:
21.5		 5vkqA-5y4eA:
11.66
5vkqD-5y4eA:
11.66