SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 7 TYR A 737
THR A 724
SER A 693
TYR A 728
 None
 1.35A 1eiiA-5y4fA:
undetectable		 1eiiA-5y4fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 12 LEU A 746
LEU A 747
ALA A 710
HIS A 774
ILE A 775
 None
 1.11A 1tw4A-5y4fA:
undetectable		 1tw4A-5y4fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 8 SER A 645
ALA A 635
ALA A 668
LEU A 665
 None
 0.74A 2bxmA-5y4fA:
undetectable		 2bxmA-5y4fA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 12 THR A 729
ALA A 734
ALA A 710
THR A 714
GLY A 750
 None
 1.28A 2ve3B-5y4fA:
undetectable		 2ve3B-5y4fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5y4f ANKYRIN-2
(Homo
sapiens) 		3 / 3 PRO A 565
LEU A 581
ARG A 584
 None
 0.76A 3aqiB-5y4fA:
undetectable		 3aqiB-5y4fA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 9 GLN A 720
PHE A 745
LEU A 681
VAL A 677
ILE A 687
 None
 1.11A 3claA-5y4fA:
undetectable		 3claA-5y4fA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 12 LEU A 679
GLY A 684
ILE A 687
ILE A 656
LEU A 680
 None
 1.06A 3ogqB-5y4fA:
undetectable		 3ogqB-5y4fA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 12 PRO A 598
VAL A 601
ALA A 602
TYR A 605
SER A 574
 None
 1.14A 4mmdB-5y4fA:
undetectable		 4mmdB-5y4fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 5 ILE A 732
THR A 757
HIS A 699
TYR A 737
 None
 1.08A 4oltB-5y4fA:
undetectable		 4oltB-5y4fA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 11 ILE A 511
LEU A 500
HIS A 518
LEU A 516
ALA A 520
 None
 1.11A 4p65E-5y4fA:
undetectable
4p65F-5y4fA:
undetectable
4p65J-5y4fA:
undetectable
4p65L-5y4fA:
undetectable		 4p65E-5y4fA:
4.64
4p65F-5y4fA:
5.13
4p65J-5y4fA:
5.13
4p65L-5y4fA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 7 THR A 658
ALA A 625
THR A 624
ALA A 623
 None
 0.73A 4qw0K-5y4fA:
undetectable		 4qw0K-5y4fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 7 THR A 658
ALA A 625
THR A 624
ALA A 623
 None
 0.73A 4qw0Y-5y4fA:
undetectable		 4qw0Y-5y4fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5y4f ANKYRIN-2
(Homo
sapiens) 		3 / 3 MET A 838
HIS A 666
GLY A 694
 None
 0.75A 5gwzB-5y4fA:
undetectable		 5gwzB-5y4fA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 5 PRO A 835
THR A 729
GLN A 766
THR A 762
 None
 1.18A 5h5fA-5y4fA:
undetectable		 5h5fA-5y4fA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 9 ALA A 768
GLN A 769
PRO A 786
LEU A 812
ILE A 776
 None
 1.37A 5i73A-5y4fA:
undetectable		 5i73A-5y4fA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5y4f ANKYRIN-2
(Homo
sapiens) 		5 / 11 GLY A 694
GLY A 661
GLN A 660
GLU A 840
THR A 839
 None
 1.11A 5x1bG-5y4fA:
undetectable
5x1bN-5y4fA:
undetectable
5x1bO-5y4fA:
undetectable		 5x1bG-5y4fA:
10.57
5x1bN-5y4fA:
23.55
5x1bO-5y4fA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 487
THR A 432
ASN A 460
 None
 0.92A 6f88A-5y4fA:
undetectable		 6f88A-5y4fA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5y4f ANKYRIN-2
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 487
THR A 432
ASN A 460
 None
 0.96A 6f88B-5y4fA:
undetectable		 6f88B-5y4fA:
9.19