SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.22A 1hrkA-5y4gA:
undetectable		 1hrkA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 5 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.08A 1vidA-5y4gA:
undetectable		 1vidA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 6 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.05A 2cl5B-5y4gA:
undetectable		 2cl5B-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 ASP A 108
ARG A 161
ALA A  20
ARG A  51
 None
 1.26A 2e5dA-5y4gA:
undetectable
2e5dB-5y4gA:
undetectable		 2e5dA-5y4gA:
undetectable
2e5dB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 GLU A 207
PHE A 288
ILE A 185
LEU A 186
ILE A 208
 None
 1.17A 2e7fA-5y4gA:
undetectable		 2e7fA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2hrcA-5y4gA:
undetectable		 2hrcA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2hrcB-5y4gA:
undetectable		 2hrcB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 GLU A 207
PHE A 288
ILE A 185
LEU A 186
ILE A 208
 None
 1.17A 2ogyA-5y4gA:
undetectable		 2ogyA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 GLU A 207
PHE A 288
ILE A 185
LEU A 186
ILE A 208
 None
 1.12A 2ogyB-5y4gA:
undetectable		 2ogyB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2qd4A-5y4gA:
undetectable		 2qd4A-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2qd4B-5y4gA:
undetectable		 2qd4B-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 6 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.15A 2zvjA-5y4gA:
undetectable		 2zvjA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 GLY A 261
LYS A 275
TRP A 117
TYR A 225
 None
 1.32A 3arrA-5y4gA:
undetectable		 3arrA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 10 PHE A  31
VAL A 278
PHE A 245
VAL A  14
PHE A  43
 None
 1.39A 3u9fM-5y4gA:
0.0
3u9fN-5y4gA:
0.0		 3u9fM-5y4gA:
undetectable
3u9fN-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 11 PHE A  31
VAL A 278
PHE A 245
VAL A  14
PHE A  43
 None
 1.43A 3u9fN-5y4gA:
undetectable
3u9fO-5y4gA:
undetectable		 3u9fN-5y4gA:
undetectable
3u9fO-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 PHE A 289
VAL A 229
PHE A 228
ILE A 201
 None
 0.61A 3zjqA-5y4gA:
undetectable		 3zjqA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 PHE A 289
VAL A 229
PHE A 228
ILE A 201
 None
 0.63A 3zjqB-5y4gA:
undetectable		 3zjqB-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 PRO A 135
SER A 137
VAL A  87
TRP A 214
 None
 1.21A 4kmmA-5y4gA:
undetectable		 4kmmA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 ALA A  44
GLY A  62
GLY A  42
PHE A  43
ILE A  73
 None
 0.94A 4n49A-5y4gA:
undetectable		 4n49A-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 6 LYS A  37
GLU A  63
GLY A  62
GLY A  42
 None
 0.87A 5a06D-5y4gA:
undetectable		 5a06D-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 5 GLU A 207
TYR A 168
SER A 287
ASP A 277
 None
 1.05A 5fhrA-5y4gA:
undetectable		 5fhrA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 10 GLY A  62
THR A  41
GLN A  92
PHE A  95
LEU A  69
 None
 1.21A 5fhzC-5y4gA:
undetectable		 5fhzC-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5y4g AMBP3
(Fischerella
ambigua) 		4 / 7 ARG A 231
ASP A 277
LEU A 259
SER A 287
 None
 1.16A 5uxcA-5y4gA:
undetectable		 5uxcA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5y4g AMBP3
(Fischerella
ambigua) 		5 / 12 ILE A 201
LEU A 199
ASP A 196
LEU A 242
VAL A 260
 None
 1.10A 5uxdB-5y4gA:
undetectable		 5uxdB-5y4gA:
undetectable