SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 8 TYR A 208
HIS A 265
GLU A 269
HIS A 338
 None
ZN  A 501 ( 3.3A)
ZN  A 501 ( 2.4A)
ZN  A 501 ( 3.3A)
 0.87A 2bnnA-5y4kA:
6.3
2bnnB-5y4kA:
5.9		 2bnnA-5y4kA:
17.72
2bnnB-5y4kA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		3 / 3 GLN A 326
THR A  75
ASN A 327
 None
 0.87A 3v4tE-5y4kA:
undetectable		 3v4tE-5y4kA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 6 ILE A  91
LEU A  61
MET A 272
THR A 357
 None
 1.16A 3wg7A-5y4kA:
undetectable
3wg7J-5y4kA:
undetectable		 3wg7A-5y4kA:
20.15
3wg7J-5y4kA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 7 TRP A 318
PHE A 319
SER A 320
HIS A 285
 None
 1.07A 4o4dA-5y4kA:
undetectable		 4o4dA-5y4kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 6 HIS A 265
HIS A 338
TYR A 271
GLU A 269
 ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.3A)
AKR  A 502 (-4.7A)
ZN  A 501 ( 2.4A)
 1.04A 4pahA-5y4kA:
undetectable		 4pahA-5y4kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 6 GLU A 248
THR A 362
GLN A 369
THR A 330
 None
 1.36A 4pfjB-5y4kA:
undetectable		 4pfjB-5y4kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 5 ALA A 226
TYR A 225
PRO A 231
PHE A 127
 None
 1.25A 4ze2A-5y4kA:
undetectable		 4ze2A-5y4kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		5 / 12 GLY A 345
GLN A 348
PHE A 332
ILE A 270
THR A 357
 None
 1.14A 5fsaB-5y4kA:
undetectable		 5fsaB-5y4kA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		3 / 3 ILE A 192
MET A 272
ASP A 189
 None
 0.77A 5h2uA-5y4kA:
undetectable		 5h2uA-5y4kA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 5 GLY A 354
THR A 275
GLN A 322
THR A 342
 None
 0.91A 5h5fA-5y4kA:
undetectable		 5h5fA-5y4kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 6 TYR A 223
PHE A 340
THR A 252
GLY A 222
 None
 1.14A 5mraA-5y4kA:
undetectable
5mraB-5y4kA:
undetectable		 5mraA-5y4kA:
15.40
5mraB-5y4kA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 4 HIS A 265
HIS A 338
TYR A 271
GLU A 269
 ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.3A)
AKR  A 502 (-4.7A)
ZN  A 501 ( 2.4A)
 1.03A 5pahA-5y4kA:
undetectable		 5pahA-5y4kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5y4k DMSP LYASE DDDY
(Acinetobacter
bereziniae) 		4 / 6 TRP A 315
LEU A 355
TYR A 262
GLN A 294
 None
 1.41A 6djzC-5y4kA:
4.8		 6djzC-5y4kA:
18.72