SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 4 ILE A 212
MET A  44
VAL A  81
GLY A 213
 None
 1.21A 1e06B-5y50A:
undetectable		 1e06B-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		3 / 3 PHE A 170
LEU A 163
SER A 182
 None
 0.89A 1e7aA-5y50A:
undetectable		 1e7aA-5y50A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 GLU A 250
THR A  90
ALA A  87
LEU A  84
 None
 1.08A 1etb2-5y50A:
undetectable		 1etb2-5y50A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 12 GLY A 202
GLY A 204
SER A 205
ALA A 208
LEU A 197
 None
 1.09A 1i9gA-5y50A:
undetectable		 1i9gA-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA257_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 4 THR A 312
ALA A 309
GLN A 171
MET A  37
 None
 1.35A 1jgsA-5y50A:
1.0		 1jgsA-5y50A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 12 VAL A 344
LEU A 299
SER A 297
HIS A 386
GLU A 265
 None
 1.08A 1kw0A-5y50A:
undetectable		 1kw0A-5y50A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 11 VAL A 344
LEU A 299
SER A 297
HIS A 386
GLU A 265
 None
 1.04A 1mmtA-5y50A:
undetectable		 1mmtA-5y50A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 5 LEU A 179
LEU A 163
MET A 227
THR A 312
 None
 1.38A 2oaxD-5y50A:
undetectable		 2oaxD-5y50A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 12 GLY A 202
GLY A 204
SER A 205
ALA A 208
LEU A 197
 None
 1.07A 2yvlA-5y50A:
undetectable		 2yvlA-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 HIS A 107
THR A 110
LEU A  91
LEU A  88
 None
 1.19A 3bgdA-5y50A:
undetectable		 3bgdA-5y50A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 VAL A 106
LYS A 103
GLN A 100
GLY A  97
 None
 1.06A 3bjwE-5y50A:
undetectable		 3bjwE-5y50A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 7 VAL A 348
ILE A 302
THR A 337
GLY A 345
 None
 0.87A 3gssA-5y50A:
1.8		 3gssA-5y50A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 7 VAL A 348
ILE A 302
THR A 337
GLY A 345
 None
 0.90A 3gssB-5y50A:
2.4		 3gssB-5y50A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		3 / 3 ASP A 400
PHE A 254
SER A 396
 None
 0.95A 3i5uB-5y50A:
undetectable		 3i5uB-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		3 / 3 ARG A 461
LYS A 462
LYS A 458
 None
 1.11A 4k50A-5y50A:
undetectable		 4k50A-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		3 / 3 ARG A 461
LYS A 462
LYS A 458
 None
 1.19A 4k50E-5y50A:
undetectable		 4k50E-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		3 / 3 ARG A 461
LYS A 462
LYS A 458
 None
 1.17A 4k50I-5y50A:
1.3		 4k50I-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 GLU A 304
ARG A 168
GLU A  89
SER A 311
 None
 1.32A 4kr3A-5y50A:
undetectable		 4kr3A-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 12 GLY A 397
GLY A 391
GLY A 395
HIS A 386
ILE A 262
 None
 0.96A 5ehgC-5y50A:
undetectable		 5ehgC-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 5 HIS A 386
VAL A 451
GLY A 391
ALA A 393
 None
 1.05A 5hwaA-5y50A:
undetectable		 5hwaA-5y50A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 10 ILE A  68
LEU A 133
PHE A  72
GLY A 277
ALA A 286
 None
 1.20A 5mxbA-5y50A:
undetectable		 5mxbA-5y50A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 12 GLY A 397
GLY A 391
GLY A 395
HIS A 386
ILE A 262
 None
 0.92A 5njvC-5y50A:
undetectable		 5njvC-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 GLY A 395
THR A  90
GLU A  89
SER A  86
 None
 1.07A 5ny7A-5y50A:
undetectable		 5ny7A-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 6 LEU A 378
SER A 379
PHE A 382
ASP A 383
 None
 0.67A 5om3A-5y50A:
undetectable
5om3B-5y50A:
undetectable		 5om3A-5y50A:
19.39
5om3B-5y50A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
CYH A  92
GLY A  93
VAL A 467
TYR A 101
 None
 1.46A 5tqrB-5y50A:
undetectable		 5tqrB-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		5 / 11 PHE A  78
GLY A  77
GLY A  83
GLN A 164
THR A 162
 None
 1.44A 5x1bG-5y50A:
undetectable
5x1bN-5y50A:
0.5
5x1bO-5y50A:
undetectable		 5x1bG-5y50A:
undetectable
5x1bN-5y50A:
undetectable
5x1bO-5y50A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5y50 PROTEIN
DETOXIFICATION 14
(Arabidopsis
thaliana) 		4 / 7 GLY A 207
ALA A 208
VAL A  70
LEU A 153
 None
 0.84A 6dwnB-5y50A:
2.0		 6dwnB-5y50A:
22.99