SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 439
TYR A 447
ARG B 355
TYR B 356
 None
 1.49A 1ceaA-5y58A:
undetectable
1ceaB-5y58A:
undetectable		 1ceaA-5y58A:
19.35
1ceaB-5y58A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  93
TYR A  81
ALA A  90
GLU A  96
 None
 0.87A 1dmaA-5y58A:
undetectable		 1dmaA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 284
LEU A 401
GLY A 286
SER A 435
PHE A 386
 None
 1.22A 1fdsA-5y58A:
3.7		 1fdsA-5y58A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  57
LEU A  56
GLU A  60
GLU A  64
 None
 1.06A 1linA-5y58A:
undetectable		 1linA-5y58A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  30
LEU A  69
ARG A 167
PHE A 169
GLU A 262
 None
 1.13A 1p5zB-5y58A:
undetectable		 1p5zB-5y58A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 11 PHE B 380
LEU B 383
ALA B 410
ALA B 394
LEU B 218
 None
 1.15A 1rlbF-5y58B:
undetectable		 1rlbF-5y58B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 171
ASN A 112
ILE A  58
ILE A 257
LEU A 115
 None
 1.24A 2bjfA-5y58A:
undetectable		 2bjfA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 138
ASP A  89
ASN A  86
 None
 1.17A 2bm9A-5y58A:
3.1		 2bm9A-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 500
ASP A  63
ASP A 113
 None
 1.10A 2br4A-5y58A:
2.2		 2br4A-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 11 GLU B 181
VAL B 180
ILE B 158
LEU B 160
ILE B 107
 None
 1.20A 2dg9A-5y58B:
undetectable		 2dg9A-5y58B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  30
LEU A  69
ARG A 167
PHE A 169
GLU A 262
 None
 1.13A 2no0A-5y58A:
1.5		 2no0A-5y58A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  30
LEU A  69
ARG A 167
PHE A 169
GLU A 262
 None
 1.13A 2no0B-5y58A:
undetectable		 2no0B-5y58A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  30
LEU A  69
ARG A 167
PHE A 169
GLU A 262
 None
 1.09A 2ziaA-5y58A:
undetectable		 2ziaA-5y58A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLY A 338
ASP A 339
ILE B 542
THR B  80
LEU B  34
 None
 1.19A 3bexC-5y58A:
undetectable
3bexD-5y58A:
undetectable		 3bexC-5y58A:
undetectable
3bexD-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 THR B  80
LEU B  34
GLY A 338
ASP A 339
ILE B 542
 None
 1.20A 3bexE-5y58B:
undetectable
3bexF-5y58B:
undetectable		 3bexE-5y58B:
undetectable
3bexF-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLY A 338
ASP A 339
ILE B 542
THR B  80
LEU B  34
 None
 1.23A 3bf1A-5y58A:
undetectable
3bf1B-5y58A:
undetectable		 3bf1A-5y58A:
undetectable
3bf1B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 THR B  80
LEU B  34
GLY A 338
ASP A 339
ILE B 542
 None
 1.21A 3bf1A-5y58B:
undetectable
3bf1B-5y58B:
undetectable		 3bf1A-5y58B:
undetectable
3bf1B-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLY A 338
ASP A 339
ILE B 542
THR B  80
LEU B  34
 None
 1.17A 3bf1C-5y58A:
undetectable
3bf1D-5y58A:
undetectable		 3bf1C-5y58A:
undetectable
3bf1D-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 THR B  80
LEU B  34
GLY A 338
ASP A 339
ILE B 542
 None
 1.22A 3bf1C-5y58B:
undetectable
3bf1D-5y58B:
undetectable		 3bf1C-5y58B:
undetectable
3bf1D-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 GLY A 338
ASP A 339
ILE B 542
THR B  80
LEU B  34
 None
 1.22A 3bf1E-5y58A:
undetectable
3bf1F-5y58A:
undetectable		 3bf1E-5y58A:
undetectable
3bf1F-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 THR B  80
LEU B  34
GLY A 338
ASP A 339
ILE B 542
 None
 1.22A 3bf1E-5y58B:
undetectable
3bf1F-5y58B:
undetectable		 3bf1E-5y58B:
undetectable
3bf1F-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  98
GLN A 160
THR A  76
VAL A 201
THR A 152
 None
 1.35A 3em0B-5y58A:
undetectable		 3em0B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 VAL B  12
VAL B  55
PHE B  66
VAL B  22
 None
 0.96A 3fhxB-5y58B:
undetectable		 3fhxB-5y58B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		3 / 3 MET A 535
MET B 408
PHE B 339
 None
 1.14A 3gn8A-5y58A:
undetectable		 3gn8A-5y58A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 PHE B 347
ALA B 394
ALA B 396
LEU A 545
 None
 1.04A 3l4dD-5y58B:
undetectable		 3l4dD-5y58B:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 431
THR B 432
ALA B 394
ALA B 396
LEU B 344
 None
 1.18A 3p5nA-5y58B:
undetectable		 3p5nA-5y58B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 6 GLN B 226
MET A 535
ILE B 222
SER B 233
 None
 1.28A 3pmzD-5y58B:
undetectable		 3pmzD-5y58B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  40
PHE A 131
GLN A 139
 None
 0.76A 3r55A-5y58A:
undetectable		 3r55A-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 191
ASP A 195
LEU A 150
ASN A 199
ASP A 198
 None
 1.45A 3sfuC-5y58A:
undetectable		 3sfuC-5y58A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 130
THR B   7
THR B   6
SER B   5
 None
 1.21A 3snfA-5y58B:
undetectable		 3snfA-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 273
LEU B 558
PHE A 362
ILE A 366
VAL B 529
 None
 1.06A 3w67B-5y58A:
3.4		 3w67B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  29
SER B  25
ILE B  68
LEU B  50
PHE B 133
 None
 1.19A 3w68A-5y58B:
3.1		 3w68A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  29
SER B  25
ILE B  68
LEU B  50
VAL B  12
 None
 1.05A 3w68A-5y58B:
3.1		 3w68A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 352
PRO B 556
PRO B 559
ILE B 566
VAL B 529
 None
 1.44A 4eb6B-5y58A:
undetectable
4eb6C-5y58A:
undetectable		 4eb6B-5y58A:
11.70
4eb6C-5y58A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 342
CYH B 239
MET B 387
LEU B 348
PHE B 347
 None
 1.38A 4iaqA-5y58B:
undetectable		 4iaqA-5y58B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 411
ARG B 217
SER B 360
VAL B 406
 None
 1.09A 4klrA-5y58B:
3.4		 4klrA-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 377
ASN A 380
TYR A 447
ILE A 375
 None
 1.45A 4o0oA-5y58A:
undetectable		 4o0oA-5y58A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU B  30
ILE B 198
ILE A 342
LEU A 344
ILE B 542
 None
 1.12A 4o1eB-5y58B:
undetectable		 4o1eB-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 5 PHE B 427
HIS B 418
LEU A 461
PRO A 459
 None
 1.43A 4o8zA-5y58B:
3.8		 4o8zA-5y58B:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 327
LEU B 326
GLN B 333
 None
 0.73A 4pevB-5y58B:
3.1		 4pevB-5y58B:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 242
PRO A 243
ALA A 204
 None
 0.55A 4qn9B-5y58A:
undetectable		 4qn9B-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 10 VAL B  75
LYS B  36
LEU B  72
PHE B   8
THR B   6
 None
 1.33A 4zmeB-5y58B:
undetectable		 4zmeB-5y58B:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 320
LEU A  62
PHE A 171
ILE A 253
PHE A  34
 None
 1.17A 5eskA-5y58B:
undetectable		 5eskA-5y58B:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 121
PHE A  43
PHE A  82
ASP A 127
 None
 1.11A 5hieA-5y58A:
undetectable		 5hieA-5y58A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  38
PHE A 129
LEU A 115
LEU A 111
PHE A  82
 None
 1.28A 5ieoA-5y58A:
2.2		 5ieoA-5y58A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 9 ILE B  84
MET B  17
VAL B  12
LEU B  50
LEU B  33
 None
 1.04A 5iepA-5y58B:
undetectable		 5iepA-5y58B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 LEU A 432
LEU A 405
ILE B 585
THR A 400
 None
 1.06A 5ljbA-5y58A:
undetectable		 5ljbA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		3 / 3 CYH B 163
MET B  16
ASN B  19
 None
 1.17A 5qh8A-5y58B:
undetectable		 5qh8A-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 5 LEU B  50
VAL B  10
MET B  16
CYH B  91
 None
 1.50A 5te0A-5y58B:
undetectable		 5te0A-5y58B:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 104
ALA A 105
ASP B 322
TYR B 319
 None
 1.16A 5umd2-5y58A:
undetectable
5umdF-5y58A:
undetectable		 5umd2-5y58A:
15.73
5umdF-5y58A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 449
HIS A 376
SER A 433
THR A 431
 None
 0.98A 5vkqA-5y58A:
3.2
5vkqD-5y58A:
3.1		 5vkqA-5y58A:
undetectable
5vkqD-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 433
THR A 431
VAL A 449
HIS A 376
 None
 0.99A 5vkqA-5y58A:
3.2
5vkqB-5y58A:
3.2		 5vkqA-5y58A:
undetectable
5vkqB-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 433
THR A 431
VAL A 449
HIS A 376
 None
 0.97A 5vkqB-5y58A:
3.2
5vkqC-5y58A:
3.1		 5vkqB-5y58A:
undetectable
5vkqC-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 433
THR A 431
VAL A 449
HIS A 376
 None
 0.99A 5vkqC-5y58A:
3.1
5vkqD-5y58A:
3.1		 5vkqC-5y58A:
undetectable
5vkqD-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 ILE B 555
ARG B 533
GLN B 534
TYR A 335
 None
 1.15A 5vlmF-5y58B:
undetectable		 5vlmF-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  83
VAL B  12
MET B  16
VAL B  22
LEU B  33
 None
 1.20A 5x24A-5y58B:
undetectable		 5x24A-5y58B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 274
ARG A 369
THR A 431
LEU A 432
 None
 0.85A 5xdqA-5y58A:
2.3
5xdqJ-5y58A:
undetectable		 5xdqA-5y58A:
undetectable
5xdqJ-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  41
LYS B  36
ARG B  86
 U  X 290 ( 4.6A)
None
None
 1.17A 6c06D-5y58B:
undetectable		 6c06D-5y58B:
undetectable