SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.12A 1bsxA-5y59B:
undetectable		 1bsxA-5y59B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.12A 1bsxB-5y59B:
undetectable		 1bsxB-5y59B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.21A 1xzxX-5y59B:
undetectable		 1xzxX-5y59B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		6 / 12 ILE B   9
LEU B 140
ILE B 183
LEU B 154
ILE B 130
THR B 134
 None
 1.24A 2d0kA-5y59B:
undetectable		 2d0kA-5y59B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 11 GLU B 181
VAL B 180
ILE B 158
LEU B 160
ILE B 107
 None
 1.05A 2dg9A-5y59B:
undetectable		 2dg9A-5y59B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 183
LEU B 154
ASP B 148
ALA B 182
 None
 1.03A 2opxA-5y59B:
undetectable		 2opxA-5y59B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 130
THR B   7
THR B   6
SER B   5
 None
 1.21A 3snfA-5y59B:
undetectable		 3snfA-5y59B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 SER B  98
SER B  99
ASN B 100
GLY B 102
 None
 0.65A 4fo4B-5y59B:
undetectable		 4fo4B-5y59B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  83
GLY B  82
TYR B  49
PHE B  66
 None
 0.92A 5flcB-5y59B:
undetectable		 5flcB-5y59B:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  83
GLY B  82
TYR B  49
PHE B  66
 None
 0.93A 5flcF-5y59B:
undetectable		 5flcF-5y59B:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0B-5y59B:
3.5		 6ew0B-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0D-5y59B:
2.8		 6ew0D-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0F-5y59B:
2.7		 6ew0F-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0G-5y59B:
3.2		 6ew0G-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0H-5y59B:
2.9		 6ew0H-5y59B:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B 113
ASP B 116
LEU B  87
LEU B  29
ARG B  86
 None
 1.11A 6ew0I-5y59B:
2.7		 6ew0I-5y59B:
16.05