SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		3 / 3 GLN A  99
TYR A 213
ARG A 212
 None
 0.85A 1gtbA-5y5aA:
2.1		 1gtbA-5y5aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5y5a KLLA0F20702P
KLLA0F20922P
(Kluyveromyces
lactis) 		4 / 6 GLU A 523
LEU B 217
VAL A 186
MET A 187
 None
 0.90A 1hk1A-5y5aA:
undetectable		 1hk1A-5y5aA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5y5a KLLA0F20702P
KLLA0F20922P
(Kluyveromyces
lactis) 		4 / 7 GLU A 523
LEU B 217
VAL A 186
MET A 187
 None
 0.87A 1hk3A-5y5aA:
undetectable		 1hk3A-5y5aA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 7 PHE A 434
PHE A 427
PHE A 430
MET A 314
 None
 1.11A 1wrlE-5y5aA:
undetectable		 1wrlE-5y5aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 10 ALA A  79
LEU A 148
LEU A 175
SER A  53
ASN A 145
 None
 1.33A 2ceoB-5y5aA:
undetectable		 2ceoB-5y5aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 12 ALA A  79
THR A  12
PHE A  16
ILE A  46
PHE A  13
 None
 1.33A 2v95A-5y5aA:
undetectable		 2v95A-5y5aA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 7 PHE A 432
LEU A 473
ALA A 476
PHE A 577
 None
 0.91A 2vcvA-5y5aA:
undetectable		 2vcvA-5y5aA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 7 PHE A 432
LEU A 473
ALA A 476
PHE A 577
 None
 0.98A 2vcvL-5y5aA:
4.0		 2vcvL-5y5aA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 8 ILE A 439
LEU A 570
VAL A 567
LEU A 456
 None
 0.89A 2w98B-5y5aA:
undetectable		 2w98B-5y5aA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 12 THR A  86
LEU A  20
MET A  35
ILE A  39
HIS A  43
 None
 1.39A 2ydoA-5y5aA:
undetectable		 2ydoA-5y5aA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 8 ASN A 471
LYS A 470
PRO A 526
PHE A 524
 None
 1.30A 3bjwD-5y5aA:
undetectable		 3bjwD-5y5aA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 11 LEU A 521
PHE A 524
ILE A 367
PHE A 239
ASP A 226
 None
 1.36A 3ko0C-5y5aA:
undetectable
3ko0D-5y5aA:
1.2
3ko0E-5y5aA:
undetectable
3ko0F-5y5aA:
undetectable		 3ko0C-5y5aA:
19.80
3ko0D-5y5aA:
19.80
3ko0E-5y5aA:
19.80
3ko0F-5y5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 11 ASP A 226
PHE A 239
LEU A 521
PHE A 524
ILE A 367
 None
 1.38A 3ko0C-5y5aA:
undetectable
3ko0D-5y5aA:
1.2
3ko0E-5y5aA:
undetectable
3ko0F-5y5aA:
undetectable		 3ko0C-5y5aA:
19.80
3ko0D-5y5aA:
19.80
3ko0E-5y5aA:
19.80
3ko0F-5y5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 11 LEU A 521
PHE A 524
ILE A 367
PHE A 239
ASP A 226
 None
 1.40A 3ko0O-5y5aA:
undetectable
3ko0P-5y5aA:
undetectable
3ko0Q-5y5aA:
undetectable
3ko0R-5y5aA:
undetectable		 3ko0O-5y5aA:
19.80
3ko0P-5y5aA:
19.80
3ko0Q-5y5aA:
19.80
3ko0R-5y5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 11 ASP A 226
PHE A 239
LEU A 521
PHE A 524
ILE A 367
 None
 1.35A 3ko0Q-5y5aA:
undetectable
3ko0R-5y5aA:
undetectable
3ko0S-5y5aA:
undetectable
3ko0T-5y5aA:
1.2		 3ko0Q-5y5aA:
19.80
3ko0R-5y5aA:
19.80
3ko0S-5y5aA:
19.80
3ko0T-5y5aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 7 ASP A 226
GLN A 241
PRO A 221
GLN A 200
 None
 1.11A 3l2vA-5y5aA:
undetectable		 3l2vA-5y5aA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 12 ARG A 460
ASP A 533
ASP A 536
TYR A 513
GLU A 517
 None
 1.47A 3lmyA-5y5aA:
undetectable		 3lmyA-5y5aA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 12 ARG A 460
ASP A 533
ASP A 536
TYR A 513
GLU A 517
 None
 1.44A 3lmyB-5y5aA:
undetectable		 3lmyB-5y5aA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 11 LEU A 291
GLY A 323
LEU A 279
ALA A 256
PHE A 430
 None
 1.13A 4wnuA-5y5aA:
1.9		 4wnuA-5y5aA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		4 / 7 CYH A 198
ILE A 196
LEU A 225
ALA A 228
 None
 0.95A 5hrqE-5y5aA:
undetectable
5hrqF-5y5aA:
undetectable
5hrqJ-5y5aA:
undetectable		 5hrqE-5y5aA:
undetectable
5hrqF-5y5aA:
undetectable
5hrqJ-5y5aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5y5a KLLA0F20702P
KLLA0F20922P
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		5 / 12 GLN B 219
ILE A 183
LEU A 267
SER A 234
GLU A 523
 None
 1.17A 5l8oB-5y5aB:
undetectable		 5l8oB-5y5aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5y5a KLLA0F20702P
(Kluyveromyces
lactis) 		5 / 12 PRO A 526
ILE A 322
ILE A 379
PHE A 427
THR A 277
 None
 1.25A 5tiwB-5y5aA:
undetectable		 5tiwB-5y5aA:
undetectable