SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		4 / 8 LYS A 200
ARG A 459
GLY A 415
GLU A 286
 ADP  A 702 (-2.7A)
None
MN  A 701 ( 4.9A)
MN  A 701 (-2.6A)
 0.94A 2ys6A-5y6nA:
undetectable		 2ys6A-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		4 / 5 ILE A 221
ARG A 298
MET A 315
THR A 316
 None
 1.09A 3abkN-5y6nA:
undetectable
3abkW-5y6nA:
undetectable		 3abkN-5y6nA:
undetectable
3abkW-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		5 / 12 THR A 201
VAL A 227
LEU A 386
SER A 412
ILE A 384
 MN  A 701 ( 3.2A)
None
None
None
None
 1.38A 3frqA-5y6nA:
undetectable		 3frqA-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		5 / 12 GLY A 299
SER A 302
THR A 303
LEU A 507
ARG A 509
 None
 1.27A 3iv6B-5y6nA:
undetectable		 3iv6B-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		6 / 12 GLY A 299
SER A 302
THR A 303
ILE A 295
LEU A 507
ARG A 509
 None
 1.36A 3iv6D-5y6nA:
3.4		 3iv6D-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		4 / 7 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.92A 4cp4A-5y6nA:
undetectable		 4cp4A-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		5 / 12 VAL A 533
ALA A 490
LEU A 270
LEU A 271
ARG A 529
 None
 1.18A 4i1rA-5y6nA:
undetectable		 4i1rA-5y6nA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		4 / 7 ARG A 298
VAL A 515
TRP A 487
GLU A 489
 None
 1.46A 4jseA-5y6nA:
undetectable
4jseB-5y6nA:
undetectable		 4jseA-5y6nA:
12.29
4jseB-5y6nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		4 / 4 THR A 449
ARG A 456
GLU A 413
VAL A 448
 None
 1.08A 4odoC-5y6nA:
undetectable		 4odoC-5y6nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN
(Zika
virus) 		5 / 9 PHE A 391
SER A 387
LEU A 386
GLU A 394
ILE A 384
 None
 1.31A 6fdyU-5y6nA:
undetectable		 6fdyU-5y6nA:
15.19