SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 4 SER A 240
LEU A 216
TYR A 256
GLY A 182
 None
 1.13A 1liiA-5y6tA:
1.7		 1liiA-5y6tA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 12 GLY A 308
GLY A 334
MET A  36
HIS A 278
ILE A  41
 None
 1.09A 2b25B-5y6tA:
undetectable		 2b25B-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		6 / 12 ASN A 178
GLU A 179
HIS A 278
TYR A 280
GLU A 309
TRP A 338
 TRS  A 401 (-2.8A)
TRS  A 401 (-2.8A)
None
TRS  A 401 (-4.8A)
TRS  A 401 (-2.6A)
TRS  A 401 (-3.7A)
 0.85A 2v3dA-5y6tA:
6.6		 2v3dA-5y6tA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 12 ALA A 335
SER A  37
ILE A 372
GLY A 369
PHE A  35
 None
 1.13A 3nrrB-5y6tA:
undetectable		 3nrrB-5y6tA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		3 / 3 HIS A 278
SER A 290
ASN A 305
 None
 0.87A 3s8pB-5y6tA:
undetectable		 3s8pB-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 12 LEU A 124
ILE A  67
GLY A  75
ILE A 374
ILE A 372
 None
 1.21A 3uj7A-5y6tA:
undetectable		 3uj7A-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 4 PRO A 180
LEU A 216
ILE A 144
ARG A 141
 None
 1.36A 3w1wA-5y6tA:
undetectable		 3w1wA-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 10 ALA A 170
GLY A 172
LEU A 376
LEU A  20
ILE A 374
 None
 1.11A 3wdmB-5y6tA:
undetectable		 3wdmB-5y6tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 10 ALA A 170
GLY A 172
LEU A 376
LEU A  20
ILE A 374
 None
 1.01A 3wdmD-5y6tA:
undetectable		 3wdmD-5y6tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 6 ILE A 235
VAL A  22
LYS A 303
LEU A  27
 None
 1.03A 4em2A-5y6tA:
undetectable		 4em2A-5y6tA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 7 TYR A 256
LEU A 238
ASN A 178
TYR A 140
 None
None
TRS  A 401 (-2.8A)
None
 1.30A 4f8yC-5y6tA:
undetectable
4f8yD-5y6tA:
undetectable		 4f8yC-5y6tA:
16.23
4f8yD-5y6tA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		3 / 3 MET A 107
HIS A  83
GLY A 100
 None
 0.62A 5gwzB-5y6tA:
undetectable		 5gwzB-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 8 VAL A 234
ILE A 235
ILE A 374
PHE A 126
 None
 0.92A 5hw8H-5y6tA:
undetectable		 5hw8H-5y6tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 4 GLN A  44
THR A  59
GLU A  64
LEU A  78
 None
 1.45A 5m66A-5y6tA:
undetectable		 5m66A-5y6tA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 6 LEU A  78
TRP A 336
SER A  37
GLY A  75
 None
 1.08A 5o4yF-5y6tA:
undetectable		 5o4yF-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 6 HIS A 278
VAL A 128
LEU A 238
THR A 237
 None
 1.28A 5ogjB-5y6tA:
undetectable		 5ogjB-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		4 / 5 HIS A 278
VAL A 128
LEU A 238
THR A 237
 None
 1.27A 5ohhA-5y6tA:
undetectable		 5ohhA-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 10 ILE A  70
TYR A  66
ILE A  80
ILE A 127
LEU A 171
 None
 1.45A 5vkqA-5y6tA:
undetectable
5vkqB-5y6tA:
undetectable		 5vkqA-5y6tA:
undetectable
5vkqB-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5y6t ENDO-1,4-BETA-MANNAN
ASE
(Eisenia
fetida) 		5 / 11 SER A 337
LEU A 357
SER A  77
ALA A 335
PHE A 324
 None
 1.36A 6qgbA-5y6tA:
undetectable		 6qgbA-5y6tA:
undetectable