SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5y7f UGGT
(Thermomyces
dupontii) 		5 / 12 GLY A1372
LEU A1261
LEU A1391
LEU A1277
LEU A1377
 None
 0.98A 1mx1F-5y7fA:
undetectable		 1mx1F-5y7fA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5y7f UGGT
(Thermomyces
dupontii) 		3 / 3 MET A1321
ASN A1431
GLN A1445
 None
 0.98A 1xoqB-5y7fA:
undetectable		 1xoqB-5y7fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 4 LEU A1391
PRO A1392
LEU A1370
ARG A1369
 None
 1.36A 2hrcA-5y7fA:
undetectable		 2hrcA-5y7fA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 5 LEU A1277
ASP A1280
LEU A1384
HIS A1375
 None
 1.24A 2jfaA-5y7fA:
undetectable		 2jfaA-5y7fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 4 LEU A1391
PRO A1392
LEU A1370
ARG A1369
 None
 1.38A 2pnjB-5y7fA:
undetectable		 2pnjB-5y7fA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 7 GLY A1273
PHE A1195
ILE A1227
PHE A1283
 None
 1.04A 2qmzA-5y7fA:
undetectable
2qmzB-5y7fA:
undetectable		 2qmzA-5y7fA:
19.86
2qmzB-5y7fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 5 LEU A1277
ASP A1280
LEU A1384
HIS A1375
 None
 1.20A 2qxsB-5y7fA:
undetectable		 2qxsB-5y7fA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 4 ILE A1271
GLN A1264
ILE A1227
LEU A1384
 UDP  A2001 (-4.1A)
None
None
None
 1.31A 3dzyD-5y7fA:
undetectable		 3dzyD-5y7fA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5y7f UGGT
(Thermomyces
dupontii) 		5 / 12 PHE A1333
ILE A1350
ASP A1427
LEU A1387
LYS A1384
 None
None
CA  A2003 ( 2.2A)
None
None
 1.36A 3lcvB-5y7fA:
undetectable		 3lcvB-5y7fA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5y7f UGGT
(Thermomyces
dupontii) 		3 / 3 GLU A1448
TYR A1452
SER A1213
 None
 0.92A 4at0A-5y7fA:
undetectable		 4at0A-5y7fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 8 ILE A1401
PRO A1315
LEU A1370
ILE A1399
 None
 0.94A 4dtaB-5y7fA:
undetectable		 4dtaB-5y7fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 7 ILE A1399
PHE A1318
LEU A1279
ILE A1276
 None
 0.75A 4rmjA-5y7fA:
undetectable		 4rmjA-5y7fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 8 TYR A1274
TRP A1257
TYR A1255
LEU A1261
 None
 1.31A 5kxiA-5y7fA:
undetectable
5kxiB-5y7fA:
undetectable		 5kxiA-5y7fA:
20.74
5kxiB-5y7fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5y7f UGGT
(Thermomyces
dupontii) 		4 / 8 TYR A1274
TRP A1257
TYR A1255
LEU A1261
 None
 1.32A 5kxiD-5y7fA:
undetectable
5kxiE-5y7fA:
undetectable		 5kxiD-5y7fA:
20.74
5kxiE-5y7fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5y7f UGGT
(Thermomyces
dupontii) 		5 / 12 ILE A1350
LEU A1311
ILE A1399
LEU A1279
ILE A1276
 None
 1.04A 5mugA-5y7fA:
undetectable		 5mugA-5y7fA:
20.95