SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 4 LYS A 513
ALA A 516
MET A 582
 None
 0.62A 1hk3A-5y7oA:
undetectable		 1hk3A-5y7oA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 GLU A  93
HIS A  95
ASP A  66
 None
 0.63A 1i9gA-5y7oA:
undetectable		 1i9gA-5y7oA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.16A 1v55C-5y7oA:
undetectable
1v55N-5y7oA:
2.3
1v55P-5y7oA:
undetectable		 1v55C-5y7oA:
13.77
1v55N-5y7oA:
17.60
1v55P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 4 ILE A  89
ASP A  75
LEU A  46
ARG A  67
 None
 1.26A 2a7qA-5y7oA:
undetectable		 2a7qA-5y7oA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 5 ILE A 303
LEU A 313
ASP A 919
ALA A 300
 None
 0.74A 2opxA-5y7oA:
undetectable		 2opxA-5y7oA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 811
GLN A 663
PRO A 662
 None
 0.97A 2qhfA-5y7oA:
undetectable		 2qhfA-5y7oA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 PRO A 223
GLY A  43
TYR A 122
 None
 0.60A 2vouA-5y7oA:
undetectable		 2vouA-5y7oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 PRO A 223
GLY A  43
TYR A 122
 None
 0.60A 2vouB-5y7oA:
undetectable		 2vouB-5y7oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 PRO A 223
GLY A  43
TYR A 122
 None
 0.58A 2vouC-5y7oA:
undetectable		 2vouC-5y7oA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 ASP A  66
ILE A  68
LEU A  50
GLU A  93
 None
 1.07A 2ya7A-5y7oA:
undetectable		 2ya7A-5y7oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 ASP A  66
ILE A  68
LEU A  50
GLU A  93
 None
 1.06A 2ya7B-5y7oA:
undetectable		 2ya7B-5y7oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 ASP A  66
ILE A  68
LEU A  50
GLU A  93
 None
 1.06A 2ya7D-5y7oA:
undetectable		 2ya7D-5y7oA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.13A 3ablA-5y7oA:
2.2
3ablC-5y7oA:
undetectable
3ablP-5y7oA:
undetectable		 3ablA-5y7oA:
17.60
3ablC-5y7oA:
13.77
3ablP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.14A 3abmA-5y7oA:
2.3
3abmC-5y7oA:
undetectable
3abmP-5y7oA:
undetectable		 3abmA-5y7oA:
17.60
3abmC-5y7oA:
13.77
3abmP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.20A 3asnC-5y7oA:
undetectable
3asnN-5y7oA:
2.3
3asnP-5y7oA:
undetectable		 3asnC-5y7oA:
13.77
3asnN-5y7oA:
17.60
3asnP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 9 VAL A 467
LEU A 451
ARG A 465
ILE A 633
ILE A 624
 None
 1.18A 3cv9A-5y7oA:
undetectable		 3cv9A-5y7oA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 TYR A 124
ASP A 176
HIS A 146
 None
 0.94A 3e23A-5y7oA:
undetectable		 3e23A-5y7oA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 ILE A 945
GLN A 926
THR A 314
VAL A 327
LEU A 295
 None
 1.32A 3em0B-5y7oA:
undetectable		 3em0B-5y7oA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 GLU A 200
GLY A  71
ALA A  69
GLU A  70
ASP A  74
 None
 1.37A 3nmuA-5y7oA:
undetectable
3nmuF-5y7oA:
undetectable		 3nmuA-5y7oA:
15.58
3nmuF-5y7oA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ILE A 633
ALA A 450
LEU A 451
LEU A 644
 None
 0.87A 3ozwA-5y7oA:
2.1		 3ozwA-5y7oA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.18A 3wg7A-5y7oA:
2.2
3wg7C-5y7oA:
undetectable
3wg7P-5y7oA:
undetectable		 3wg7A-5y7oA:
17.60
3wg7C-5y7oA:
13.77
3wg7P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.20A 3wg7C-5y7oA:
undetectable
3wg7N-5y7oA:
undetectable
3wg7P-5y7oA:
undetectable		 3wg7C-5y7oA:
13.77
3wg7N-5y7oA:
17.60
3wg7P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.10A 3x2qA-5y7oA:
2.2
3x2qC-5y7oA:
undetectable
3x2qP-5y7oA:
undetectable		 3x2qA-5y7oA:
17.60
3x2qC-5y7oA:
13.77
3x2qP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 GLN A 567
ASP A 553
GLN A 549
 None
 0.81A 4aztA-5y7oA:
undetectable		 4aztA-5y7oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.14A 4b7nA-5y7oA:
undetectable		 4b7nA-5y7oA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.13A 4cpzC-5y7oA:
undetectable		 4cpzC-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.06A 4cpzE-5y7oA:
undetectable		 4cpzE-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.11A 4cpzF-5y7oA:
undetectable		 4cpzF-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.17A 4cpzG-5y7oA:
undetectable		 4cpzG-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 ARG A 924
ARG A 927
TRP A 928
 None
 1.15A 4cpzH-5y7oA:
undetectable		 4cpzH-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 PRO A1001
ASP A 368
TRP A1004
SER A 371
 None
 1.07A 4k7gB-5y7oA:
undetectable		 4k7gB-5y7oA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 VAL A 638
HIS A 468
LEU A 460
LEU A 451
 None
 0.93A 4l1wA-5y7oA:
undetectable		 4l1wA-5y7oA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 VAL A 638
HIS A 468
LEU A 460
LEU A 451
 None
 0.97A 4l1xA-5y7oA:
undetectable		 4l1xA-5y7oA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 PHE A 492
HIS A 488
ILE A 489
PHE A 614
 None
 1.46A 4o7gB-5y7oA:
undetectable		 4o7gB-5y7oA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 LEU A 503
PHE A 535
VAL A 485
HIS A 508
SER A 509
 None
 1.23A 4ydqA-5y7oA:
3.1		 4ydqA-5y7oA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.19A 5b1aA-5y7oA:
2.3
5b1aC-5y7oA:
undetectable
5b1aP-5y7oA:
undetectable		 5b1aA-5y7oA:
17.60
5b1aC-5y7oA:
13.77
5b1aP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.19A 5b3sA-5y7oA:
2.2
5b3sC-5y7oA:
undetectable
5b3sP-5y7oA:
undetectable		 5b3sA-5y7oA:
17.60
5b3sC-5y7oA:
13.77
5b3sP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 GLU A  93
HIS A  95
ASP A  66
 None
 0.75A 5c0oG-5y7oA:
undetectable		 5c0oG-5y7oA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 372
LEU A 938
ARG A 380
LEU A 966
 None
 1.25A 5dxeA-5y7oA:
undetectable		 5dxeA-5y7oA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.16A 5iy5C-5y7oA:
undetectable
5iy5N-5y7oA:
2.2
5iy5P-5y7oA:
undetectable		 5iy5C-5y7oA:
13.24
5iy5N-5y7oA:
17.60
5iy5P-5y7oA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 11 HIS A 121
SER A 206
PHE A  62
TYR A 216
VAL A 193
 None
 1.45A 5jdcA-5y7oA:
2.3
5jdcD-5y7oA:
undetectable		 5jdcA-5y7oA:
13.79
5jdcD-5y7oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 5 VAL A 813
ASN A 657
ASP A 826
LEU A 822
 None
 1.16A 5m0iB-5y7oA:
undetectable		 5m0iB-5y7oA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 LEU A  73
LEU A  49
ALA A  53
ARG A  67
ARG A 177
 None
 1.20A 5nd3B-5y7oA:
undetectable		 5nd3B-5y7oA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 5 THR A 314
THR A 903
HIS A 899
LEU A 304
 None
 1.30A 5utuH-5y7oA:
undetectable		 5utuH-5y7oA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 ASP A 999
ARG A 960
PHE A 961
ALA A 326
ALA A 921
 None
 1.18A 5vc0A-5y7oA:
undetectable		 5vc0A-5y7oA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 4 SER A 745
THR A 790
ASP A 796
ASP A 705
 None
 1.37A 5vimA-5y7oA:
undetectable		 5vimA-5y7oA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 4 SER A 745
THR A 790
ASP A 796
ASP A 705
 None
 1.41A 5vimB-5y7oA:
undetectable		 5vimB-5y7oA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5w97A-5y7oA:
undetectable
5w97C-5y7oA:
undetectable
5w97c-5y7oA:
undetectable		 5w97A-5y7oA:
17.60
5w97C-5y7oA:
13.77
5w97c-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.19A 5w97C-5y7oA:
undetectable
5w97a-5y7oA:
undetectable
5w97c-5y7oA:
undetectable		 5w97C-5y7oA:
13.77
5w97a-5y7oA:
17.60
5w97c-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5wauA-5y7oA:
2.6
5wauC-5y7oA:
undetectable
5wauc-5y7oA:
undetectable		 5wauA-5y7oA:
17.60
5wauC-5y7oA:
13.77
5wauc-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.13A 5wauC-5y7oA:
undetectable
5waua-5y7oA:
2.6
5wauc-5y7oA:
undetectable		 5wauC-5y7oA:
13.77
5waua-5y7oA:
17.60
5wauc-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.16A 5x19A-5y7oA:
2.3
5x19C-5y7oA:
undetectable
5x19P-5y7oA:
undetectable		 5x19A-5y7oA:
17.60
5x19C-5y7oA:
13.77
5x19P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.19A 5x1bA-5y7oA:
0.5
5x1bC-5y7oA:
undetectable
5x1bP-5y7oA:
undetectable		 5x1bA-5y7oA:
17.60
5x1bC-5y7oA:
13.77
5x1bP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.14A 5x1fA-5y7oA:
undetectable
5x1fC-5y7oA:
undetectable
5x1fP-5y7oA:
undetectable		 5x1fA-5y7oA:
17.60
5x1fC-5y7oA:
13.77
5x1fP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.16A 5xdqA-5y7oA:
2.3
5xdqC-5y7oA:
undetectable
5xdqP-5y7oA:
undetectable		 5xdqA-5y7oA:
17.60
5xdqC-5y7oA:
13.77
5xdqP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.20A 5xdqC-5y7oA:
undetectable
5xdqN-5y7oA:
2.3
5xdqP-5y7oA:
undetectable		 5xdqC-5y7oA:
13.77
5xdqN-5y7oA:
17.60
5xdqP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 LEU A 503
PHE A 535
VAL A 485
HIS A 508
SER A 509
 None
 1.15A 5xiqA-5y7oA:
3.2		 5xiqA-5y7oA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 LEU A 503
PHE A 535
VAL A 485
HIS A 508
SER A 509
 None
 1.24A 5xiqB-5y7oA:
2.4		 5xiqB-5y7oA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 LEU A 719
GLN A 767
LEU A 748
LEU A 751
 None
 1.18A 5yvnA-5y7oA:
undetectable		 5yvnA-5y7oA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5z84A-5y7oA:
undetectable
5z84C-5y7oA:
undetectable
5z84P-5y7oA:
undetectable		 5z84A-5y7oA:
17.60
5z84C-5y7oA:
13.77
5z84P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.21A 5z84C-5y7oA:
undetectable
5z84N-5y7oA:
2.2
5z84P-5y7oA:
undetectable		 5z84C-5y7oA:
13.77
5z84N-5y7oA:
17.60
5z84P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.18A 5z85A-5y7oA:
undetectable
5z85C-5y7oA:
undetectable
5z85P-5y7oA:
undetectable		 5z85A-5y7oA:
17.60
5z85C-5y7oA:
13.77
5z85P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 7 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.20A 5z85C-5y7oA:
undetectable
5z85N-5y7oA:
2.2
5z85P-5y7oA:
undetectable		 5z85C-5y7oA:
13.77
5z85N-5y7oA:
17.60
5z85P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5z86A-5y7oA:
2.3
5z86C-5y7oA:
undetectable
5z86P-5y7oA:
undetectable		 5z86A-5y7oA:
17.60
5z86C-5y7oA:
13.77
5z86P-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5zcoA-5y7oA:
2.2
5zcoC-5y7oA:
undetectable
5zcoP-5y7oA:
undetectable		 5zcoA-5y7oA:
17.60
5zcoC-5y7oA:
13.77
5zcoP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.20A 5zcoC-5y7oA:
undetectable
5zcoN-5y7oA:
undetectable
5zcoP-5y7oA:
undetectable		 5zcoC-5y7oA:
13.77
5zcoN-5y7oA:
17.60
5zcoP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.20A 5zcpA-5y7oA:
2.2
5zcpC-5y7oA:
undetectable
5zcpP-5y7oA:
undetectable		 5zcpA-5y7oA:
17.60
5zcpC-5y7oA:
13.77
5zcpP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 602
ASP A 418
THR A 655
TYR A 417
 None
 1.21A 5zcpC-5y7oA:
undetectable
5zcpN-5y7oA:
2.2
5zcpP-5y7oA:
undetectable		 5zcpC-5y7oA:
13.77
5zcpN-5y7oA:
17.60
5zcpP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ASP A 418
THR A 655
TYR A 417
LEU A 602
 None
 1.17A 5zcqA-5y7oA:
2.3
5zcqC-5y7oA:
undetectable
5zcqP-5y7oA:
undetectable		 5zcqA-5y7oA:
17.60
5zcqC-5y7oA:
13.77
5zcqP-5y7oA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 LEU A 372
LEU A 938
ARG A 380
LEU A 966
 None
 1.26A 6cbzA-5y7oA:
undetectable		 6cbzA-5y7oA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5y7o UGGT
(Thermomyces
dupontii) 		3 / 3 SER A 650
SER A 646
ALA A 637
 None
 0.56A 6dwnC-5y7oA:
undetectable		 6dwnC-5y7oA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 6 VAL A 813
LEU A 822
LEU A 714
MET A 700
 None
 0.81A 6f6sA-5y7oA:
undetectable
6f6sB-5y7oA:
undetectable		 6f6sA-5y7oA:
5.68
6f6sB-5y7oA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5y7o UGGT
(Thermomyces
dupontii) 		4 / 8 ILE A 472
ALA A 603
VAL A 606
ASP A 466
 None
 0.87A 6hu9a-5y7oA:
undetectable
6hu9e-5y7oA:
undetectable		 6hu9a-5y7oA:
18.85
6hu9e-5y7oA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5y7o UGGT
(Thermomyces
dupontii) 		5 / 12 LEU A 503
PHE A 535
VAL A 485
HIS A 508
SER A 509
 None
 1.11A 6mn8A-5y7oA:
2.0		 6mn8A-5y7oA:
19.15