SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 THR B 209
THR B 206
GLU B  28
HIS B  30
 None
 1.20A 1d4fB-5y7rB:
undetectable		 1d4fB-5y7rB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 12 GLY B 213
LEU B 159
LEU B 124
LEU B 225
HIS B 134
 AKG  B 402 (-2.9A)
AKG  B 402 (-4.4A)
None
None
58K  B 403 (-3.4A)
 1.25A 1mx1C-5y7rB:
undetectable		 1mx1C-5y7rB:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 LEU B 204
GLY B 177
PRO B  12
ALA B  33
 None
 0.96A 2aohA-5y7rB:
undetectable		 2aohA-5y7rB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 ILE B 283
LEU B 276
ASP B 113
ALA B 263
 None
 1.00A 2opxA-5y7rB:
undetectable		 2opxA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 11 PHE B  38
SER B  97
ILE B 103
PHE B 158
LEU B 226
 None
 1.37A 3a9eB-5y7rB:
undetectable		 3a9eB-5y7rB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 10 LEU B 225
HIS B 134
ASP B 136
ILE B 205
HIS B 211
 None
58K  B 403 (-3.4A)
FE  B 401 (-2.6A)
None
FE  B 401 ( 3.3A)
 0.77A 3kcxA-5y7rB:
11.3		 3kcxA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		3 / 3 LEU B 184
TRP B 181
GLY B 177
 None
 0.73A 3l35A-5y7rB:
undetectable
3l35H-5y7rB:
undetectable		 3l35A-5y7rB:
undetectable
3l35H-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		3 / 3 LEU B 184
TRP B 181
GLY B 177
 None
 0.70A 3l35B-5y7rB:
undetectable
3l35K-5y7rB:
undetectable		 3l35B-5y7rB:
undetectable
3l35K-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.37A 3uq6A-5y7rB:
undetectable		 3uq6A-5y7rB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 4 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.25A 3vaqA-5y7rB:
undetectable		 3vaqA-5y7rB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 4 LEU B 226
ALA B 202
PHE B  38
ASN B 157
 None
None
None
58K  B 403 ( 3.7A)
 1.29A 3vasA-5y7rB:
undetectable		 3vasA-5y7rB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 7 VAL B  80
VAL B 121
LEU B 226
VAL B  44
 None
 0.81A 4e1gB-5y7rB:
undetectable		 4e1gB-5y7rB:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 7 ASP B 136
LEU B 238
ASN B  70
LEU B  79
 FE  B 401 (-2.6A)
None
58K  B 403 (-3.5A)
58K  B 403 (-4.6A)
 1.13A 4ib4A-5y7rB:
undetectable		 4ib4A-5y7rB:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		4 / 5 ARG B 194
GLY B 170
ALA B 171
GLY B 213
 None
None
None
AKG  B 402 (-2.9A)
 0.86A 4u9uA-5y7rB:
undetectable		 4u9uA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 7 LEU B  39
ASN B  48
LEU B  47
ARG B 224
LEU B 226
 None
 1.50A 4wg0B-5y7rB:
undetectable
4wg0C-5y7rB:
undetectable		 4wg0B-5y7rB:
undetectable
4wg0C-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 12 TYR B 114
PHE B 158
ILE B 103
GLY B 231
LEU B 259
 None
 1.19A 5zwrA-5y7rB:
undetectable		 5zwrA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ
(Aspergillus
nidulans) 		5 / 12 TYR B  90
ILE B 228
LEU B 100
ALA B 256
LEU B 255
 None
 1.25A 5zwrB-5y7rB:
undetectable		 5zwrB-5y7rB:
undetectable