SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Bos
taurus) 		5 / 11 HIS B 214
VAL B 218
LEU B 221
LEU B 209
THR B 208
 None
 1.18A 1dmyA-5y7yB:
undetectable		 1dmyA-5y7yB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 4 SER A 131
SER A 269
LEU A 128
PHE A 271
 GOL  A 301 (-3.5A)
None
None
None
 1.44A 1r5lA-5y7yA:
undetectable		 1r5lA-5y7yA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 4 LEU A  73
SER A  76
TYR A  77
LEU A  55
 None
 0.65A 1xz1A-5y7yA:
undetectable		 1xz1A-5y7yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 4 LEU A  73
SER A  76
TYR A  77
LEU A  55
 None
 0.67A 1xz3A-5y7yA:
undetectable		 1xz3A-5y7yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Bos
taurus) 		5 / 12 HIS B 367
PHE B 429
LEU B 391
VAL B 376
VAL B 384
 None
 1.22A 3czvA-5y7yB:
undetectable
3czvB-5y7yB:
undetectable		 3czvA-5y7yB:
21.50
3czvB-5y7yB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Bos
taurus) 		5 / 9 LEU B 423
VAL B 416
ILE B 369
GLY B 371
ILE B 396
 None
 1.09A 3ekqB-5y7yB:
undetectable		 3ekqB-5y7yB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 6 LEU A  73
SER A  76
TYR A  77
LEU A  55
 None
 0.75A 3rd0A-5y7yA:
undetectable		 3rd0A-5y7yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Bos
taurus;
Homo
sapiens) 		4 / 5 LEU A 248
TRP A 177
ILE B 458
ASN B 461
 None
 1.14A 4i00A-5y7yA:
undetectable		 4i00A-5y7yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Homo
sapiens;
Bos
taurus) 		3 / 3 GLU B 111
ARG A  79
HIS A 156
 None
GOL  A 301 ( 4.3A)
None
 0.43A 4kf9A-5y7yB:
undetectable		 4kf9A-5y7yB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Homo
sapiens;
Bos
taurus) 		5 / 10 LEU A  71
LEU A  51
LEU A  54
ILE B 109
VAL B 116
 None
 1.14A 4mk4A-5y7yA:
undetectable		 4mk4A-5y7yA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Bos
taurus;
Homo
sapiens) 		4 / 8 ASN B 448
PRO B 449
PHE B 446
TRP A 177
 None
 1.34A 4v2zC-5y7yB:
undetectable		 4v2zC-5y7yB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 7 SER A  76
TYR A  77
PRO A  56
PHE A 137
 None
 1.11A 5aclA-5y7yA:
undetectable		 5aclA-5y7yA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Homo
sapiens;
Bos
taurus) 		3 / 3 ASP A 161
LEU A  68
ARG B 101
 None
 0.84A 5e8qA-5y7yA:
undetectable		 5e8qA-5y7yA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Bos
taurus;
Homo
sapiens) 		4 / 6 ILE B 369
PHE B 412
PHE B 446
TRP A 177
 None
 1.29A 5g08A-5y7yB:
undetectable		 5g08A-5y7yB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Homo
sapiens;
Bos
taurus) 		4 / 5 TYR A  77
LYS A  81
LEU B 159
GLU B 163
 None
 1.43A 5js1A-5y7yA:
undetectable		 5js1A-5y7yA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		4 / 7 VAL A 154
HIS A 150
ILE A  61
SER A  76
 None
 1.03A 5vkqA-5y7yA:
undetectable
5vkqD-5y7yA:
undetectable		 5vkqA-5y7yA:
9.56
5vkqD-5y7yA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Bos
taurus) 		4 / 5 GLU B 362
PHE B 363
ASP B 377
THR B 383
 None
 1.37A 6b58A-5y7yB:
undetectable		 6b58A-5y7yB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
(Bos
taurus) 		5 / 12 LEU B 423
ILE B 369
GLY B 371
ILE B 396
VAL B 415
 None
 0.97A 6dh0A-5y7yB:
undetectable		 6dh0A-5y7yB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		5 / 12 LEU A 268
LEU A 203
ALA A 178
HIS A 176
ASP A 196
 None
 1.19A 6n91A-5y7yA:
undetectable		 6n91A-5y7yA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens) 		5 / 12 LEU A 268
LEU A 203
ALA A 178
HIS A 176
ASP A 196
 None
 1.21A 6n91B-5y7yA:
undetectable		 6n91B-5y7yA:
12.78