SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 HIS F 192
PHE F 189
ASP F 299
ASP F 298
 None
 1.05A 1ilqA-5y81F:
undetectable
1ilqC-5y81F:
undetectable		 1ilqA-5y81F:
20.29
1ilqC-5y81F:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 ILE F  28
GLY F 455
VAL F  17
ALA F  16
LEU F  94
 None
 0.97A 1vptA-5y81F:
undetectable		 1vptA-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5y81 TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 THR B2836
ARG B3439
TRP B3542
GLU B2641
 None
 1.16A 1xr2B-5y81B:
undetectable		 1xr2B-5y81B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU F 424
LEU F 385
ALA F 289
ILE F 249
ILE F 417
 None
 1.08A 2bxcA-5y81F:
undetectable		 2bxcA-5y81F:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ASN F  27
ASP F  20
THR F 414
GLY F 413
 None
 1.05A 2f6dA-5y81F:
undetectable		 2f6dA-5y81F:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 PRO F  41
GLY F  63
SER F  42
ILE F  74
GLY F  45
 None
 1.07A 3axzA-5y81F:
undetectable		 3axzA-5y81F:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 HIS F 162
GLY F 413
GLY F 412
LEU F 410
SER F 421
 None
 1.21A 3i5uB-5y81F:
undetectable		 3i5uB-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5y81 TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE B3548
SER B3554
VAL B3556
VAL B3581
 None
 1.15A 3n61A-5y81B:
undetectable
3n61B-5y81B:
undetectable		 3n61A-5y81B:
12.90
3n61B-5y81B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5y81 TRANSCRIPTION-ASSOCI
ATED PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE B3548
SER B3554
VAL B3556
VAL B3581
 None
 1.16A 3nlrA-5y81B:
undetectable
3nlrB-5y81B:
undetectable		 3nlrA-5y81B:
12.90
3nlrB-5y81B:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 LEU F 440
ASP F 159
VAL F 157
GLY F 455
VAL F 409
 None
 0.91A 3so9B-5y81F:
undetectable		 3so9B-5y81F:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 LEU F 129
PHE F 134
PRO F 107
ALA F 108
 None
 1.43A 3vm4A-5y81F:
undetectable		 3vm4A-5y81F:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 GLU F 474
GLY F 471
TYR F 475
GLU F 130
 None
 1.45A 3w9tA-5y81F:
undetectable		 3w9tA-5y81F:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 GLU F 474
GLY F 471
TYR F 475
GLU F 130
 None
 1.46A 3w9tC-5y81F:
undetectable		 3w9tC-5y81F:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 GLU F 474
GLY F 471
TYR F 475
GLU F 130
 None
 1.44A 3w9tD-5y81F:
undetectable		 3w9tD-5y81F:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 5 GLU F 474
GLY F 471
TYR F 475
GLU F 130
 None
 1.44A 3w9tG-5y81F:
undetectable		 3w9tG-5y81F:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		3 / 3 TYR F 286
HIS F 248
ARG F 285
 None
 1.04A 4e7bC-5y81F:
undetectable		 4e7bC-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 PHE F 238
ILE F 204
PRO F 205
PHE F 239
 None
 0.91A 4fgkA-5y81F:
undetectable		 4fgkA-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG F 236
SER F  42
GLY F 413
THR F 442
 None
 0.93A 5btaA-5y81F:
undetectable
5btaC-5y81F:
undetectable
5btaD-5y81F:
2.0		 5btaA-5y81F:
9.46
5btaC-5y81F:
9.46
5btaD-5y81F:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 SER F  42
GLY F 413
THR F 442
ARG F 236
 None
 0.94A 5btaA-5y81F:
undetectable
5btaB-5y81F:
2.3
5btaC-5y81F:
undetectable		 5btaA-5y81F:
9.46
5btaB-5y81F:
14.34
5btaC-5y81F:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG F 236
SER F  42
GLY F 413
THR F 442
 None
 0.94A 5btcA-5y81F:
undetectable
5btcC-5y81F:
undetectable
5btcD-5y81F:
2.3		 5btcA-5y81F:
9.46
5btcC-5y81F:
9.46
5btcD-5y81F:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 6 SER F  42
GLY F 413
THR F 442
ARG F 236
 None
 0.93A 5btcA-5y81F:
undetectable
5btcB-5y81F:
undetectable
5btcC-5y81F:
undetectable		 5btcA-5y81F:
9.46
5btcB-5y81F:
14.34
5btcC-5y81F:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG F 236
SER F  42
GLY F 413
THR F 442
 None
 0.97A 5btfA-5y81F:
undetectable
5btfC-5y81F:
undetectable
5btfD-5y81F:
2.2		 5btfA-5y81F:
9.46
5btfC-5y81F:
9.46
5btfD-5y81F:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY F  32
TYR F  30
LEU F 462
GLY F 456
ILE F 458
 None
 0.97A 5d4uC-5y81F:
undetectable		 5d4uC-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY F  32
TYR F  30
LEU F 462
GLY F 456
ILE F 458
 None
 0.97A 5d4uD-5y81F:
undetectable		 5d4uD-5y81F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 9 ALA F 405
PHE F 437
PRO F 433
LEU F 432
ILE F 393
 None
 1.16A 5i73A-5y81F:
undetectable		 5i73A-5y81F:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5y81 ACTIN-RELATED
PROTEIN 4
(Saccharomyces
cerevisiae) 		5 / 12 PHE F 293
ALA F 186
LEU F 410
ILE F 439
LEU F 420
 None
 1.18A 6aybA-5y81F:
undetectable		 6aybA-5y81F:
9.95