SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		3 / 3 TRP A 240
VAL A 235
TRP A 239
 None
 1.34A 1gmkC-5y83A:
undetectable
1gmkD-5y83A:
undetectable		 1gmkC-5y83A:
undetectable
1gmkD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		5 / 12 THR A 117
GLY A  91
VAL A  92
SER A 104
ARG A 189
 None
 1.47A 1jdvE-5y83A:
undetectable
1jdvF-5y83A:
undetectable		 1jdvE-5y83A:
18.22
1jdvF-5y83A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 5 PHE A  72
PHE A 178
HIS A 172
VAL A 192
 None
 1.13A 2lh6A-5y83A:
undetectable		 2lh6A-5y83A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 6 LEU A 170
VAL A 192
PHE A  72
PHE A  65
 None
 1.12A 3soaA-5y83A:
undetectable		 3soaA-5y83A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 8 GLY A  91
VAL A  92
ILE A 118
PHE A  44
 None
 0.94A 4fglD-5y83A:
undetectable		 4fglD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 7 ILE A 118
THR A  37
VAL A 128
PHE A  54
 None
 1.30A 4iarA-5y83A:
undetectable		 4iarA-5y83A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		5 / 11 GLY A 180
PHE A  72
ASP A  73
ILE A  50
PRO A 141
 None
 1.50A 4rtrA-5y83A:
undetectable		 4rtrA-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 4 LEU A 406
GLY A 405
SER A 404
SER A 353
 None
 1.31A 5uunA-5y83A:
undetectable		 5uunA-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		4 / 4 LEU A 406
GLY A 405
SER A 404
SER A 353
 None
 1.34A 5uunB-5y83A:
undetectable		 5uunB-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5y83 MEMBRANE PROTEIN
INSERTASE YIDC
(Thermotoga
maritima) 		3 / 3 PHE A  44
ASP A  45
LYS A  52
 None
 0.87A 6awtD-5y83A:
undetectable		 6awtD-5y83A:
undetectable