SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		5 / 11 GLY A 284
LEU A 283
GLY A  47
HIS A 192
GLU A 246
 HEM  A 401 ( 4.0A)
HEM  A 401 ( 4.3A)
HEM  A 401 (-4.5A)
HEM  A 401 ( 3.4A)
None
 1.43A 1iolA-5y89A:
2.7		 1iolA-5y89A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 LEU A 187
VAL A 186
ILE A 210
LEU A 277
LEU A 282
 None
 1.09A 1s19A-5y89A:
undetectable		 1s19A-5y89A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		3 / 3 THR A  72
SER A 107
LYS A 141
 HEM  A 401 (-3.1A)
None
None
 1.06A 3aocC-5y89A:
undetectable		 3aocC-5y89A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 6 CYH A  73
THR A  74
GLY A  46
ASP A  70
 None
None
HEM  A 401 ( 4.1A)
None
 1.32A 3w9tE-5y89A:
undetectable		 3w9tE-5y89A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 GLY A 284
GLY A  47
ARG A 288
ALA A 205
PHE A 281
 HEM  A 401 ( 4.0A)
HEM  A 401 (-4.5A)
None
HEM  A 401 (-3.3A)
None
 1.12A 4kicA-5y89A:
2.9		 4kicA-5y89A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 VAL A 274
LEU A 257
ILE A 243
LEU A 242
 None
 0.82A 4mghA-5y89A:
3.6		 4mghA-5y89A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 ALA A 213
TYR A 212
PRO A 290
PHE A 285
 None
 1.31A 4ze2A-5y89A:
undetectable		 4ze2A-5y89A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 HIS A 254
VAL A 241
GLY A 269
ALA A 268
 None
 0.87A 5hwaA-5y89A:
undetectable		 5hwaA-5y89A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 4 GLU A  60
THR A  61
THR A  52
LEU A 105
 None
 1.46A 5v96A-5y89A:
3.2		 5v96A-5y89A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 4 GLU A  60
THR A  61
THR A  52
LEU A 105
 None
 1.45A 5v96C-5y89A:
undetectable		 5v96C-5y89A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 4 GLU A  60
THR A  61
THR A  52
LEU A 105
 None
 1.44A 5v96D-5y89A:
undetectable		 5v96D-5y89A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 LEU A  49
ALA A  53
LEU A  56
LEU A  66
 None
 0.87A 5vkqA-5y89A:
undetectable
5vkqD-5y89A:
undetectable		 5vkqA-5y89A:
9.97
5vkqD-5y89A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 LEU A  66
LEU A  49
ALA A  53
LEU A  56
 None
 0.86A 5vkqA-5y89A:
undetectable
5vkqB-5y89A:
undetectable		 5vkqA-5y89A:
9.97
5vkqB-5y89A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 LEU A  66
LEU A  49
ALA A  53
LEU A  56
 None
 0.83A 5vkqB-5y89A:
undetectable
5vkqC-5y89A:
undetectable		 5vkqB-5y89A:
9.97
5vkqC-5y89A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 5 LEU A  66
LEU A  49
ALA A  53
LEU A  56
 None
 0.89A 5vkqC-5y89A:
undetectable
5vkqD-5y89A:
undetectable		 5vkqC-5y89A:
9.97
5vkqD-5y89A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		4 / 8 GLY A 214
TRP A 166
GLN A 167
VAL A 173
 None
 1.01A 5vlmA-5y89A:
undetectable		 5vlmA-5y89A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 GLY A 269
ALA A 268
ASP A 239
VAL A 189
VAL A 241
 None
 0.81A 6dh0A-5y89A:
undetectable		 6dh0A-5y89A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5y89 PUTATIVE HEMIN
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Burkholderia
cenocepacia) 		5 / 12 GLY A 269
ALA A 268
ASP A 239
VAL A 189
VAL A 241
 None
 0.79A 6dh0B-5y89A:
undetectable		 6dh0B-5y89A:
16.53