SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 279
SER A 237
ASN A 242
 None
 0.77A 1bx4A-5y8pA:
undetectable		 1bx4A-5y8pA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A   8
GLY A  10
MET A  12
VAL A  61
ILE A  89
 None
 1.13A 2b25B-5y8pA:
5.5		 2b25B-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 164
GLY A 162
ASP A 115
ALA A 116
HIS A 157
 None
 0.87A 2gluA-5y8pA:
6.4		 2gluA-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 162
GLY A 135
GLY A 159
GLY A 164
 None
 0.55A 3bogC-5y8pA:
undetectable		 3bogC-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 162
GLY A 135
GLY A 159
GLY A 164
 None
 0.54A 3bogD-5y8pA:
undetectable		 3bogD-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  91
MET A 151
PHE A 132
ILE A  89
 None
 1.02A 3g59A-5y8pA:
undetectable		 3g59A-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A   4
ALA A  58
LEU A   7
LEU A   9
VAL A  27
 None
None
None
None
GOL  A 301 (-4.0A)
 1.06A 3ix9B-5y8pA:
undetectable		 3ix9B-5y8pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A   8
GLY A  10
LEU A  65
PRO A  66
VAL A  70
 None
 0.71A 4gc9A-5y8pA:
undetectable		 4gc9A-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A   8
GLY A  13
ILE A  62
LEU A  65
PRO A  66
VAL A  70
 None
 1.35A 4gc9A-5y8pA:
undetectable		 4gc9A-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 164
GLY A 162
CYH A 158
HIS A 157
ILE A 156
 None
 0.99A 4krhA-5y8pA:
4.3		 4krhA-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 164
GLY A 162
CYH A 158
HIS A 157
ILE A 156
 None
 0.97A 4krhB-5y8pA:
4.7		 4krhB-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  45
ALA A  41
GLY A  13
SER A  38
GLY A  39
 GOL  A 301 ( 4.9A)
None
None
None
None
 1.24A 4mmdA-5y8pA:
undetectable		 4mmdA-5y8pA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  45
ALA A  41
GLY A  13
SER A  38
GLY A  39
 GOL  A 301 ( 4.9A)
None
None
None
None
 1.21A 4mmdB-5y8pA:
0.7		 4mmdB-5y8pA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 LYS A 243
LEU A 247
ILE A  94
VAL A  71
 None
 1.22A 4tvtA-5y8pA:
undetectable		 4tvtA-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A  16
ASP A  90
PHE A  88
 None
 1.06A 4xeyA-5y8pA:
undetectable		 4xeyA-5y8pA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A   8
GLY A  10
ASP A  31
PRO A  32
LEU A  65
 None
 0.86A 5bw4A-5y8pA:
4.9		 5bw4A-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A   8
GLY A  10
PRO A  32
ALA A  33
LEU A  65
 None
 0.97A 5bw4B-5y8pA:
4.7		 5bw4B-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A  17
HIS A  43
PRO A  15
LEU A   9
 None
 1.20A 5dzka-5y8pA:
2.2
5dzko-5y8pA:
undetectable		 5dzka-5y8pA:
undetectable
5dzko-5y8pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 102
SER A  92
MET A 133
 None
 0.49A 5ikqA-5y8pA:
undetectable		 5ikqA-5y8pA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5y8p PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A  34
GLY A   8
GLY A  29
VAL A  55
ALA A  41
 None
 1.01A 6nj9K-5y8pA:
3.4		 6nj9K-5y8pA:
undetectable