SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 12 LEU A 392
ASN A 393
LEU A 253
GLN A 316
MET A 377
 None
 1.38A 2oaxE-5y92A:
undetectable		 2oaxE-5y92A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 12 LEU A 154
LEU A 130
VAL A 123
ILE A 182
GLU A 183
 None
 1.15A 2weyA-5y92A:
undetectable		 2weyA-5y92A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		3 / 3 ARG A 103
GLU A 183
SER A  71
 None
 0.87A 2xctD-5y92A:
undetectable		 2xctD-5y92A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 11 ALA A 407
LEU A 102
LEU A 104
SER A 132
LEU A 131
 None
 1.09A 2xn5A-5y92A:
undetectable		 2xn5A-5y92A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 6 ARG A 103
ASP A 229
ILE A 224
GLU A 396
 None
 1.33A 2ya7C-5y92A:
undetectable		 2ya7C-5y92A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 12 GLY A 181
LEU A 104
TYR A  90
ILE A 164
LEU A 162
 None
 0.97A 3gwvA-5y92A:
undetectable		 3gwvA-5y92A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 8 ASN A 410
THR A 139
LEU A 148
ARG A 150
 NAG  A 501 (-4.2A)
None
None
None
 1.12A 3kp2A-5y92A:
undetectable
3kp2B-5y92A:
undetectable		 3kp2A-5y92A:
undetectable
3kp2B-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 9 ASN A 410
THR A 139
ALA A 136
LEU A 148
ARG A 150
 NAG  A 501 (-4.2A)
None
None
None
None
 1.36A 3kp6B-5y92A:
undetectable		 3kp6B-5y92A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		3 / 3 ALA A 273
VAL A 275
TRP A 237
 None
 0.84A 3l8lA-5y92A:
undetectable
3l8lB-5y92A:
undetectable		 3l8lA-5y92A:
undetectable
3l8lB-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 7 LEU A 154
LEU A 130
ASN A 126
THR A 167
 None
 0.71A 3lm8B-5y92A:
2.8
3lm8D-5y92A:
2.7		 3lm8B-5y92A:
13.45
3lm8D-5y92A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 5 ARG A 103
MET A 101
HIS A 100
LEU A 154
 None
 1.18A 4g5jA-5y92A:
0.0		 4g5jA-5y92A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 8 ILE A 373
LEU A 375
ILE A 397
LEU A 395
 None
 0.82A 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable		 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		4 / 8 ILE A 397
LEU A 395
ILE A 373
LEU A 375
 None
 0.81A 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable		 4zvcA-5y92A:
undetectable
4zvcB-5y92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		5 / 12 ASP A  42
HIS A 105
LEU A 104
LEU A 102
ARG A 235
 None
 1.38A 5hnxB-5y92A:
undetectable		 5hnxB-5y92A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2
(Arabidopsis
thaliana) 		3 / 3 GLY A 348
GLY A 349
GLN A 264
 None
 0.40A 5imsA-5y92A:
undetectable		 5imsA-5y92A:
undetectable