SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y9q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		3 / 3 ASP A 108
ASN A 109
THR A  85
 None
 0.72A 2pymB-5y9qA:
undetectable		 2pymB-5y9qA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		5 / 10 LEU A 188
LEU A  67
LEU A  15
VAL A  19
PHE A 185
 None
 0.78A 2w9gA-5y9qA:
2.7		 2w9gA-5y9qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		5 / 10 LEU A 188
LEU A  15
VAL A  19
ILE A   5
PHE A 185
 None
 1.13A 2w9hA-5y9qA:
2.7		 2w9hA-5y9qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		5 / 10 LEU A 188
LEU A  67
LEU A  15
VAL A  19
PHE A 185
 None
 0.88A 2w9hA-5y9qA:
2.7		 2w9hA-5y9qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		5 / 11 LEU A 188
LEU A  67
LEU A  15
VAL A  19
PHE A 185
 None
 0.79A 3frbX-5y9qA:
undetectable		 3frbX-5y9qA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		5 / 12 THR A  39
GLY A  37
GLY A   6
SER A   9
GLN A 122
 None
 1.29A 3tkaA-5y9qA:
undetectable		 3tkaA-5y9qA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 7 ILE A  99
GLU A  91
TYR A 114
VAL A  84
 None
 1.10A 4a97A-5y9qA:
undetectable		 4a97A-5y9qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 7 ILE A  99
GLU A  91
TYR A 114
VAL A  84
 None
 1.09A 4a97H-5y9qA:
undetectable		 4a97H-5y9qA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 5 PHE A 185
PHE A  27
LEU A 188
LEU A 177
 None
 1.26A 5veuH-5y9qA:
undetectable		 5veuH-5y9qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A  95
ILE A  97
ARG A 166
TYR A 114
 None
 1.17A 6hisA-5y9qA:
undetectable
6hisB-5y9qA:
undetectable		 6hisA-5y9qA:
20.00
6hisB-5y9qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A  95
ILE A  97
ARG A 166
TYR A 114
 None
 1.18A 6hisB-5y9qA:
undetectable
6hisC-5y9qA:
undetectable		 6hisB-5y9qA:
20.00
6hisC-5y9qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A  95
ILE A  97
ARG A 166
TYR A 114
 None
 1.18A 6hisC-5y9qA:
undetectable
6hisD-5y9qA:
undetectable		 6hisC-5y9qA:
20.00
6hisD-5y9qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 8 ASP A  95
ILE A  97
ARG A 166
TYR A 114
 None
 1.17A 6hisD-5y9qA:
undetectable
6hisE-5y9qA:
undetectable		 6hisD-5y9qA:
20.00
6hisE-5y9qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5y9q CARBON CATABOLITE
RESPONSIVE REGULATOR
(Staphylococcus
aureus) 		4 / 8 TYR A 114
ASP A  95
ILE A  97
ARG A 166
 None
 1.20A 6hisA-5y9qA:
undetectable
6hisE-5y9qA:
undetectable		 6hisA-5y9qA:
20.00
6hisE-5y9qA:
20.00