SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5y9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5y9s VV2_1132
(Vibrio
vulnificus) 		6 / 12 ILE A 135
LEU A 105
PHE A 206
ILE A 275
PRO A 248
TYR A 280
 BR  A 401 ( 4.2A)
None
None
None
None
None
 1.38A 1drfA-5y9sA:
2.2		 1drfA-5y9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5y9s VV2_1132
(Vibrio
vulnificus) 		4 / 6 LEU A  61
GLU A  73
LEU A  14
LEU A  43
 None
 0.92A 1mt1D-5y9sA:
undetectable
1mt1E-5y9sA:
undetectable		 1mt1D-5y9sA:
21.05
1mt1E-5y9sA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5y9s VV2_1132
(Vibrio
vulnificus) 		5 / 12 PRO A 180
TYR A 198
SER A 200
TYR A 201
LEU A 234
 None
 1.45A 1z9hA-5y9sA:
undetectable		 1z9hA-5y9sA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5y9s VV2_1132
(Vibrio
vulnificus) 		5 / 12 PRO A 180
TYR A 198
SER A 200
TYR A 201
LEU A 234
 None
 1.45A 1z9hB-5y9sA:
undetectable		 1z9hB-5y9sA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5y9s VV2_1132
(Vibrio
vulnificus) 		5 / 12 PRO A 180
TYR A 198
SER A 200
TYR A 201
LEU A 234
 None
 1.46A 1z9hC-5y9sA:
undetectable		 1z9hC-5y9sA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5y9s VV2_1132
(Vibrio
vulnificus) 		5 / 12 SER A 231
LEU A 256
HIS A 250
LEU A 207
TYR A 153
 None
None
None
BR  A 402 (-3.8A)
None
 1.46A 1zgyA-5y9sA:
undetectable		 1zgyA-5y9sA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5y9s VV2_1132
(Vibrio
vulnificus) 		4 / 5 ALA A  42
GLN A  41
ILE A  40
ARG A  54
 None
 1.33A 2z0aA-5y9sA:
2.7		 2z0aA-5y9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5y9s VV2_1132
(Vibrio
vulnificus) 		5 / 12 SER A 231
ILE A 239
HIS A 250
LEU A 207
TYR A 153
 None
None
None
BR  A 402 (-3.8A)
None
 1.27A 5ycpA-5y9sA:
undetectable		 5ycpA-5y9sA:
20.45