SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		5 / 10 PHE A 326
VAL A 306
VAL A 273
ILE A 322
GLY A 308
 None
 1.26A 13gsA-5yacA:
undetectable		 13gsA-5yacA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		5 / 9 PHE A 326
VAL A 306
VAL A 273
ILE A 322
GLY A 308
 None
 1.25A 13gsB-5yacA:
undetectable		 13gsB-5yacA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		5 / 12 PHE A 190
GLY A 192
GLY A 194
ASN A 213
ASP A 238
 None
 1.08A 2dpmA-5yacA:
10.4		 2dpmA-5yacA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 7 GLU A 221
ALA A 191
PRO A 234
ALA A 209
 None
 1.03A 2ejfA-5yacA:
undetectable		 2ejfA-5yacA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		3 / 3 ARG A 173
ASP A 211
ASP A 238
 None
 0.52A 2ejtA-5yacA:
18.5		 2ejtA-5yacA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 5 ARG A 175
ASP A 325
ILE A 324
GLU A 172
 None
 1.05A 2xrzA-5yacA:
1.7
2xrzB-5yacA:
1.8		 2xrzA-5yacA:
24.30
2xrzB-5yacA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 7 GLU A 221
ALA A 191
PRO A 234
ALA A 209
 None
 1.09A 2zgwA-5yacA:
undetectable		 2zgwA-5yacA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 6 GLU A 221
ALA A 191
PRO A 234
ALA A 209
 None
 1.06A 2zgwB-5yacA:
undetectable		 2zgwB-5yacA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		9 / 12 TYR A 164
LEU A 169
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
LEU A 253
PHE A 260
 None
 0.70A 2zzmA-5yacA:
31.0		 2zzmA-5yacA:
42.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		3 / 3 ARG A 173
ASP A 211
ASN A 252
 None
 0.60A 2zzmA-5yacA:
31.0		 2zzmA-5yacA:
42.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		9 / 12 TYR A 164
LEU A 169
ARG A 173
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
PHE A 260
 None
 0.68A 2zznA-5yacA:
24.4		 2zznA-5yacA:
42.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		10 / 12 TYR A 164
PHE A 165
LEU A 169
ARG A 173
PHE A 190
GLY A 192
PRO A 195
ASN A 213
ASP A 238
PHE A 260
 None
 0.68A 2zznB-5yacA:
23.7		 2zznB-5yacA:
42.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		5 / 12 SER A 166
PHE A 190
ASP A 238
ARG A 240
PHE A 260
 None
 0.74A 3a27A-5yacA:
27.0		 3a27A-5yacA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		6 / 12 SER A 166
PHE A 190
GLY A 192
ASN A 213
ASP A 238
PHE A 260
 None
 0.72A 3a27A-5yacA:
27.0		 3a27A-5yacA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		8 / 10 TYR A 164
PHE A 190
ASP A 211
ASN A 213
ALA A 216
ASP A 238
LEU A 253
PHE A 260
 None
 0.62A 3ay0A-5yacA:
29.3		 3ay0A-5yacA:
42.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		8 / 10 TYR A 164
PHE A 190
GLY A 192
ASP A 211
ASN A 213
ASP A 238
LEU A 253
PHE A 260
 None
 0.67A 3ay0B-5yacA:
29.2		 3ay0B-5yacA:
42.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		6 / 10 LEU A 200
ALA A 191
ASP A 211
ILE A 235
ILE A 224
VAL A 186
 None
 1.50A 3lzvA-5yacA:
undetectable		 3lzvA-5yacA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 5 VAL A 233
LEU A 206
VAL A 185
PHE A 208
 None
 1.05A 4lb0B-5yacA:
undetectable		 4lb0B-5yacA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		5 / 9 LEU A  19
GLY A  48
VAL A   5
VAL A  42
LEU A   3
 None
 1.02A 4qd3A-5yacA:
undetectable		 4qd3A-5yacA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 6 LYS A 255
GLY A 278
TYR A 277
ALA A 323
 None
 0.91A 4yshB-5yacA:
undetectable		 4yshB-5yacA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 4 ASP A 188
GLY A 192
ASP A 211
ASP A 238
 None
 0.47A 5e72A-5yacA:
17.2		 5e72A-5yacA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B
(Pyrococcus
abyssi) 		4 / 7 ASN A 231
VAL A 207
ALA A 209
GLY A 194
 None
 0.70A 5fpdA-5yacA:
undetectable		 5fpdA-5yacA:
22.62