SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5yak -
(-) 		5 / 9 LEU A 260
GLY A 222
ILE A 120
GLY A 124
ILE A 194
 None
 1.03A 1hpvA-5yakA:
undetectable		 1hpvA-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5yak -
(-) 		4 / 5 TYR A 184
VAL A 115
ILE A 190
MET A 261
 None
 1.32A 1opjA-5yakA:
1.0		 1opjA-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5yak -
(-) 		4 / 6 VAL A 265
ILE A 120
ILE A 190
LEU A 191
 None
 0.79A 3hegA-5yakA:
undetectable		 3hegA-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5yak -
(-) 		3 / 3 LYS A 258
VAL A 198
HIS A 199
 None
 1.22A 3tj7A-5yakA:
undetectable		 3tj7A-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5yak -
(-) 		4 / 4 VAL A 111
GLU A 109
GLY A 266
LEU A 233
 None
 0.87A 5g5gC-5yakA:
undetectable		 5g5gC-5yakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5yak -
(-) 		5 / 12 LEU A 260
SER A 128
VAL A 217
ALA A 123
ALA A 220
 None
 1.18A 5tzoB-5yakA:
undetectable		 5tzoB-5yakA:
undetectable