SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 11 ALA A  11
THR A  12
LEU A 178
LEU A 115
GLY A 112
 None
 1.06A 1b02A-5yalA:
undetectable		 1b02A-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		3 / 3 SER A 176
VAL A  43
LEU A  21
 None
 0.70A 1yajG-5yalA:
7.9		 1yajG-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		4 / 7 HIS A 268
ALA A 235
GLY A 266
GLY A 267
 None
 0.63A 2c49B-5yalA:
4.0		 2c49B-5yalA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 10 PHE A 271
ASN A 310
ALA A 306
VAL A 263
LEU A 213
 None
 1.38A 3ay0A-5yalA:
2.5		 3ay0A-5yalA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		3 / 3 HIS A 268
HIS A 190
MET A 269
 None
 0.84A 3mihA-5yalA:
undetectable		 3mihA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 12 GLY A 267
GLY A 294
PHE A 271
ALA A 265
ASP A 262
 None
 0.92A 4a6dA-5yalA:
undetectable		 4a6dA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 12 GLY A 267
GLY A 294
PHE A 271
ALA A 265
ASP A 262
 None
 0.93A 4a6eA-5yalA:
undetectable		 4a6eA-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 12 ALA A 188
GLY A 189
GLY A 194
GLY A 186
PHE A 316
 None
 0.90A 4obwB-5yalA:
undetectable		 4obwB-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		3 / 3 THR A 270
PRO A 275
ASP A 279
 None
 0.70A 5l8dB-5yalA:
undetectable		 5l8dB-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		3 / 3 THR A 270
PRO A 275
ASP A 279
 None
 0.70A 5mwuB-5yalA:
undetectable		 5mwuB-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5yal ESTERASE
(Streptomyces
cinnamoneus) 		5 / 12 ALA A 188
GLY A 189
SER A  98
PHE A 316
LEU A 320
 None
 1.21A 5w7pA-5yalA:
undetectable		 5w7pA-5yalA:
undetectable