SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.07A 1c9sN-5yapA:
undetectable
1c9sO-5yapA:
undetectable
1c9sN-5yapA:
undetectable
1c9sO-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.07A 1c9sP-5yapA:
undetectable
1c9sQ-5yapA:
undetectable
1c9sP-5yapA:
undetectable
1c9sQ-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 9 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.08A 1c9sQ-5yapA:
undetectable
1c9sR-5yapA:
undetectable
1c9sQ-5yapA:
undetectable
1c9sR-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.03A 1c9sL-5yapA:
undetectable
1c9sV-5yapA:
undetectable
1c9sL-5yapA:
undetectable
1c9sV-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 9 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.10A 1gtfD-5yapA:
undetectable
1gtfE-5yapA:
undetectable
1gtfD-5yapA:
undetectable
1gtfE-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.08A 1gtfJ-5yapA:
undetectable
1gtfK-5yapA:
undetectable
1gtfJ-5yapA:
undetectable
1gtfK-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.03A 1gtfQ-5yapA:
undetectable
1gtfR-5yapA:
undetectable
1gtfQ-5yapA:
undetectable
1gtfR-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 9 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.03A 1gtfR-5yapA:
undetectable
1gtfS-5yapA:
undetectable
1gtfR-5yapA:
undetectable
1gtfS-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.03A 1gtfS-5yapA:
undetectable
1gtfT-5yapA:
undetectable
1gtfS-5yapA:
undetectable
1gtfT-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.02A 1gtnT-5yapA:
undetectable
1gtnU-5yapA:
undetectable
1gtnT-5yapA:
undetectable
1gtnU-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.10A 1utdE-5yapA:
undetectable
1utdF-5yapA:
undetectable
1utdE-5yapA:
undetectable
1utdF-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.10A 1utdH-5yapA:
undetectable
1utdI-5yapA:
undetectable
1utdH-5yapA:
undetectable
1utdI-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 12 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.03A 1utdL-5yapA:
undetectable
1utdM-5yapA:
undetectable
1utdL-5yapA:
undetectable
1utdM-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.06A 1utdS-5yapA:
undetectable
1utdT-5yapA:
undetectable
1utdS-5yapA:
undetectable
1utdT-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 269
HIS A 158
ILE A 153
GLY A 248
THR A 246
None
1.07A 1utdU-5yapA:
undetectable
1utdV-5yapA:
undetectable
1utdU-5yapA:
undetectable
1utdV-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 11 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.01A 1utdL-5yapA:
undetectable
1utdV-5yapA:
undetectable
1utdL-5yapA:
undetectable
1utdV-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 5 TRP A  67
ALA A  95
LEU A  87
ALA A  94
None
None
NAI  A 401 (-4.8A)
None
1.08A 2jstA-5yapA:
undetectable
2jstB-5yapA:
undetectable
2jstA-5yapA:
22.22
2jstB-5yapA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 12 VAL A  10
THR A  31
ASN A  28
VAL A 327
ALA A 330
None
1.11A 2x2iA-5yapA:
undetectable
2x2iA-5yapA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 12 VAL A  10
THR A  31
ASN A  28
VAL A 327
ALA A 330
None
1.18A 2x2iC-5yapA:
undetectable
2x2iC-5yapA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 12 VAL A  71
ALA A  70
GLU A  90
VAL A 102
ILE A  81
None
1.20A 3dl9A-5yapA:
undetectable
3dl9A-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 6 ARG A 262
LEU A 196
MET A 162
ASP A 164
None
1.32A 4cevA-5yapA:
3.2
4cevB-5yapA:
3.2
4cevA-5yapA:
undetectable
4cevB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 6 ARG A 262
LEU A 196
MET A 162
ASP A 164
None
1.30A 4cevD-5yapA:
3.2
4cevE-5yapA:
3.2
4cevD-5yapA:
undetectable
4cevE-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 6 ARG A 262
LEU A 196
MET A 162
ASP A 164
None
1.32A 4cevE-5yapA:
undetectable
4cevF-5yapA:
undetectable
4cevE-5yapA:
undetectable
4cevF-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
3 / 3 ARG A 334
ASP A  77
ASP A  73
None
0.57A 4kicB-5yapA:
undetectable
4kicB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
6 / 12 PHE A 250
GLY A 187
SER A 253
ALA A 361
ARG A 178
ILE A 357
None
None
None
None
NAI  A 401 (-2.7A)
None
1.41A 4krhB-5yapA:
3.9
4krhB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 4 ALA A 117
ALA A 120
ALA A 121
ALA A 124
None
0.13A 4oadA-5yapA:
undetectable
4oadA-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 6 ASP A  77
LYS A 100
HIS A 101
ARG A 127
ILE A 337
None
0.51A 5a06A-5yapA:
19.4
5a06A-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 5 ASP A  77
LYS A 100
HIS A 101
ARG A 127
ILE A 337
None
0.52A 5a06B-5yapA:
19.5
5a06B-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 5 ASP A  77
LYS A 100
HIS A 101
ARG A 127
ILE A 337
None
0.48A 5a06D-5yapA:
35.6
5a06D-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 5 ASP A  77
LYS A 100
HIS A 101
ARG A 127
ILE A 337
None
0.48A 5a06F-5yapA:
19.4
5a06F-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 7 ALA A 144
ARG A 160
GLY A 161
GLU A 249
None
0.99A 5bs8A-5yapA:
undetectable
5bs8B-5yapA:
undetectable
5bs8C-5yapA:
undetectable
5bs8A-5yapA:
11.86
5bs8B-5yapA:
17.99
5bs8C-5yapA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 7 ALA A 144
ARG A 160
GLY A 161
GLU A 249
None
0.96A 5btdA-5yapA:
undetectable
5btdB-5yapA:
undetectable
5btdC-5yapA:
undetectable
5btdA-5yapA:
11.86
5btdB-5yapA:
17.99
5btdC-5yapA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 7 ALA A 144
ARG A 160
GLY A 161
GLU A 249
None
0.92A 5btdA-5yapA:
undetectable
5btdC-5yapA:
undetectable
5btdD-5yapA:
undetectable
5btdA-5yapA:
11.86
5btdC-5yapA:
11.86
5btdD-5yapA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5eevA-5yapA:
undetectable
5eevB-5yapA:
undetectable
5eevA-5yapA:
undetectable
5eevB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5eewA-5yapA:
undetectable
5eewB-5yapA:
undetectable
5eewA-5yapA:
undetectable
5eewB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5eexA-5yapA:
undetectable
5eexB-5yapA:
undetectable
5eexA-5yapA:
undetectable
5eexB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5eeyA-5yapA:
undetectable
5eeyB-5yapA:
undetectable
5eeyA-5yapA:
undetectable
5eeyB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5eezA-5yapA:
undetectable
5eezB-5yapA:
undetectable
5eezA-5yapA:
undetectable
5eezB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.05A 5ef0A-5yapA:
undetectable
5ef0B-5yapA:
undetectable
5ef0A-5yapA:
undetectable
5ef0B-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5ef1A-5yapA:
undetectable
5ef1B-5yapA:
undetectable
5ef1A-5yapA:
undetectable
5ef1B-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.06A 5ef2A-5yapA:
undetectable
5ef2B-5yapA:
undetectable
5ef2A-5yapA:
undetectable
5ef2B-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 10 GLY A 248
THR A 246
GLY A 269
HIS A 158
ILE A 153
None
1.05A 5ef3A-5yapA:
undetectable
5ef3B-5yapA:
undetectable
5ef3A-5yapA:
undetectable
5ef3B-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 8 ASN A 323
GLU A 165
HIS A 195
THR A  15
None
8S0  A 402 (-2.8A)
8S0  A 402 ( 3.9A)
NAI  A 401 (-4.0A)
1.36A 5hqaA-5yapA:
undetectable
5hqaA-5yapA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 5 HIS A  88
ASP A 191
GLY A 190
ASN A  85
NAI  A 401 (-3.8A)
8S0  A 402 (-4.3A)
None
NAI  A 401 (-3.7A)
1.23A 5x7pB-5yapA:
undetectable
5x7pB-5yapA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
5 / 12 ILE A 357
PHE A 372
VAL A 210
LEU A 263
TYR A 135
None
None
None
None
8S0  A 402 (-4.5A)
0.95A 6djzA-5yapA:
undetectable
6djzA-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 4 LYS A  20
LEU A  54
ALA A  23
LEU A  43
None
1.42A 6gnrA-5yapA:
undetectable
6gnrA-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
4 / 4 LYS A  20
LEU A  54
ALA A  23
LEU A  43
None
1.40A 6gnrB-5yapA:
undetectable
6gnrB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivora
ns)
3 / 3 ARG A 355
LEU A 351
PHE A 347
None
0.53A 6nknP-5yapA:
undetectable
6nknP-5yapA:
undetectable