SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 8 THR A 348
GLY A  71
ALA A 132
ILE A  93
 None
 0.67A 1c9sI-5yatA:
undetectable
1c9sJ-5yatA:
undetectable		 1c9sI-5yatA:
undetectable
1c9sJ-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 8 GLY A  71
ALA A 132
ILE A  93
THR A 348
 None
 0.66A 1c9sU-5yatA:
undetectable
1c9sV-5yatA:
undetectable		 1c9sU-5yatA:
undetectable
1c9sV-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 6 LEU A 201
VAL A 222
VAL A 231
GLN A 235
 None
None
None
GOL  A 401 (-4.0A)
 1.08A 1e7aB-5yatA:
undetectable		 1e7aB-5yatA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 GLY A  71
ALA A 132
ILE A  93
THR A 348
 None
 0.66A 1gtnA-5yatA:
undetectable
1gtnK-5yatA:
undetectable		 1gtnA-5yatA:
undetectable
1gtnK-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 8 THR A 348
GLY A  71
ALA A 132
ILE A  93
 None
 0.69A 1gtnE-5yatA:
undetectable
1gtnF-5yatA:
undetectable		 1gtnE-5yatA:
undetectable
1gtnF-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 8 THR A 348
GLY A  71
ALA A 132
ILE A  93
 None
 0.71A 1gtnI-5yatA:
undetectable
1gtnJ-5yatA:
undetectable		 1gtnI-5yatA:
undetectable
1gtnJ-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 PRO A 319
ILE A 178
GLY A 186
GLY A 184
ALA A 157
 None
 0.86A 1nv8A-5yatA:
6.4		 1nv8A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 PRO A 319
ILE A 178
GLY A 186
GLY A 184
ALA A 157
 None
 0.83A 1sg9B-5yatA:
6.4		 1sg9B-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 8 GLY A  71
ALA A 132
ILE A  93
THR A 348
 None
 0.65A 1utdI-5yatA:
undetectable
1utdJ-5yatA:
undetectable		 1utdI-5yatA:
undetectable
1utdJ-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 1v54A-5yatA:
undetectable
1v54C-5yatA:
undetectable		 1v54A-5yatA:
undetectable
1v54C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.50A 1v54N-5yatA:
undetectable
1v54P-5yatA:
undetectable		 1v54N-5yatA:
undetectable
1v54P-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.47A 1v55A-5yatA:
undetectable
1v55C-5yatA:
undetectable		 1v55A-5yatA:
undetectable
1v55C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 2dyrA-5yatA:
undetectable
2dyrC-5yatA:
undetectable		 2dyrA-5yatA:
undetectable
2dyrC-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.47A 2eijA-5yatA:
undetectable
2eijC-5yatA:
undetectable		 2eijA-5yatA:
undetectable
2eijC-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 2eijN-5yatA:
undetectable
2eijP-5yatA:
undetectable		 2eijN-5yatA:
undetectable
2eijP-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.47A 2eikA-5yatA:
undetectable
2eikC-5yatA:
undetectable		 2eikA-5yatA:
undetectable
2eikC-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.48A 2eilA-5yatA:
undetectable
2eilC-5yatA:
undetectable		 2eilA-5yatA:
undetectable
2eilC-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 ILE A 203
GLY A 180
GLY A 186
GLY A 205
ILE A 246
 None
 0.99A 2fk8A-5yatA:
7.5		 2fk8A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 5 GLY A 173
TRP A 175
ARG A 199
LEU A 198
 None
 1.28A 2j2pD-5yatA:
undetectable
2j2pF-5yatA:
undetectable		 2j2pD-5yatA:
15.09
2j2pF-5yatA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 PRO A  29
LEU A 148
ALA A 149
GLN A 129
ILE A  93
 None
 1.21A 2jjpA-5yatA:
undetectable		 2jjpA-5yatA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 3abkA-5yatA:
undetectable
3abkC-5yatA:
undetectable		 3abkA-5yatA:
undetectable
3abkC-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.48A 3ag2A-5yatA:
undetectable
3ag2C-5yatA:
undetectable		 3ag2A-5yatA:
undetectable
3ag2C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 3ag3A-5yatA:
undetectable
3ag3C-5yatA:
undetectable		 3ag3A-5yatA:
undetectable
3ag3C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.48A 3ag3N-5yatA:
undetectable
3ag3P-5yatA:
undetectable		 3ag3N-5yatA:
undetectable
3ag3P-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.47A 3ag4A-5yatA:
undetectable
3ag4C-5yatA:
undetectable		 3ag4A-5yatA:
undetectable
3ag4C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 5 ASN A  39
ALA A 149
LEU A 155
GLY A  92
 None
 0.94A 3dl9A-5yatA:
undetectable		 3dl9A-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		3 / 3 GLU A  70
VAL A  45
CYH A  46
 ZN  A 404 (-2.9A)
None
ZN  A 404 (-2.2A)
 1.00A 3fbxA-5yatA:
undetectable		 3fbxA-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 VAL A 190
LEU A 188
LYS A 194
ALA A 318
LEU A 216
 None
 1.04A 4i1rA-5yatA:
3.3		 4i1rA-5yatA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 9 ALA A 168
VAL A 245
GLY A 295
VAL A 248
ILE A 246
 None
 1.11A 4ll3B-5yatA:
undetectable		 4ll3B-5yatA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 ALA A 181
GLY A 186
ILE A 203
GLY A 205
PHE A 221
 None
 1.24A 4obwD-5yatA:
6.4		 4obwD-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 5 VAL A 346
GLU A 327
VAL A 331
LYS A 330
 None
 1.18A 4p6vB-5yatA:
undetectable
4p6vE-5yatA:
undetectable		 4p6vB-5yatA:
10.79
4p6vE-5yatA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		3 / 3 GLN A 174
HIS A 243
ARG A 263
 None
 1.16A 4qyqA-5yatA:
undetectable		 4qyqA-5yatA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		3 / 3 GLN A 174
HIS A 243
ARG A 263
 None
 1.11A 4qyqB-5yatA:
undetectable		 4qyqB-5yatA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 HIS A  69
THR A  48
GLU A  70
GLY A  44
GLY A 158
 ZN  A 404 (-3.2A)
GOL  A 402 (-2.4A)
ZN  A 404 (-2.9A)
None
None
 1.30A 4uinH-5yatA:
undetectable
4uinL-5yatA:
undetectable		 4uinH-5yatA:
undetectable
4uinL-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 ILE A 246
ALA A 189
ALA A 157
ARG A 343
LEU A 185
 None
 1.18A 4zo1X-5yatA:
undetectable		 4zo1X-5yatA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.49A 5b1bN-5yatA:
undetectable
5b1bP-5yatA:
undetectable		 5b1bN-5yatA:
undetectable
5b1bP-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 9 LEU A 198
LEU A 170
ALA A 189
VAL A 248
ALA A 168
 None
 1.18A 5g44A-5yatA:
undetectable		 5g44A-5yatA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.48A 5iy5A-5yatA:
undetectable
5iy5C-5yatA:
undetectable		 5iy5A-5yatA:
undetectable
5iy5C-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 5 ASP A 135
THR A 137
GLN A 138
ARG A 301
 None
 1.33A 5k9dA-5yatA:
undetectable		 5k9dA-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 GLY A 121
GLY A 126
SER A  99
LEU A  96
HIS A  69
 None
None
ZN  A 405 ( 4.9A)
None
ZN  A 404 (-3.2A)
 0.69A 5twjA-5yatA:
undetectable		 5twjA-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 10 GLY A 121
GLY A 126
SER A  99
LEU A  96
HIS A  69
 None
None
ZN  A 405 ( 4.9A)
None
ZN  A 404 (-3.2A)
 0.69A 5twjB-5yatA:
undetectable		 5twjB-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		4 / 7 HIS A  51
TRP A  57
TYR A 297
HIS A  47
 None
GOL  A 402 (-4.7A)
None
None
 1.47A 5x1fN-5yatA:
undetectable
5x1fP-5yatA:
undetectable		 5x1fN-5yatA:
undetectable
5x1fP-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III
(Komagataella
phaffii) 		5 / 12 GLY A 186
LEU A 237
VAL A 234
ILE A 203
ASP A 204
 None
 1.08A 6bxmA-5yatA:
3.3		 6bxmA-5yatA:
undetectable