SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 TYR A1042
VAL A1116
ILE A1117
PHE A1118
ILE A1030
 None
 1.15A 1c9hA-5yaxA:
undetectable		 1c9hA-5yaxA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 ARG A  75
PRO A  46
LEU A  21
LEU A  19
ASP A  98
 None
 1.24A 1e7wA-5yaxA:
undetectable		 1e7wA-5yaxA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		6 / 12 TYR A1042
GLN A1105
PHE A1118
ASN A  40
ALA A 105
TRP A 118
 None
 0.61A 1h8sA-5yaxA:
21.6		 1h8sA-5yaxA:
32.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
 None
 1.23A 2bxfA-5yaxA:
undetectable		 2bxfA-5yaxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
 None
 1.18A 2bxfB-5yaxA:
undetectable		 2bxfB-5yaxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 7 ASP A  98
LEU A  19
ILE A  76
ARG A  75
 None
 1.01A 2qqcA-5yaxA:
undetectable
2qqcF-5yaxA:
undetectable		 2qqcA-5yaxA:
12.95
2qqcF-5yaxA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 7 ASP A  98
LEU A  19
ILE A  76
ARG A  75
 None
 1.03A 2qqcI-5yaxA:
undetectable
2qqcL-5yaxA:
undetectable		 2qqcI-5yaxA:
12.95
2qqcL-5yaxA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 GLN A1006
PHE A1118
ASN A1029
GLY A1119
ALA A 114
 None
 1.22A 3v3oB-5yaxA:
undetectable		 3v3oB-5yaxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 11 ILE A1117
SER A1106
TYR A1037
ASP A1108
LEU A1004
 None
 1.46A 4kysB-5yaxA:
undetectable		 4kysB-5yaxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 7 THR A1092
ALA A1090
SER A1022
THR A1020
 None
 0.94A 4pwjB-5yaxA:
undetectable		 4pwjB-5yaxA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 7 TYR A1038
TYR A1042
TYR A1055
PRO A1068
 None
 0.57A 5aclA-5yaxA:
21.0		 5aclA-5yaxA:
31.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 7 THR A1092
ALA A1090
SER A1022
THR A1020
 None
 0.95A 5bojB-5yaxA:
undetectable		 5bojB-5yaxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		5 / 12 TYR A1042
VAL A1116
ILE A1117
PHE A1118
ILE A1030
 None
 1.18A 5hkgA-5yaxA:
undetectable		 5hkgA-5yaxA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		6 / 12 GLY A  54
ASN A  65
VAL A  71
ILE A  42
LEU A  53
LEU A  91
 None
 1.22A 5wy0A-5yaxA:
undetectable		 5wy0A-5yaxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5yax SCFV1 ANTIBODY
(Homo
sapiens) 		4 / 6 PHE A1045
PRO A1046
GLY A1047
THR A1048
 None
 0.75A 5x24A-5yaxA:
undetectable		 5x24A-5yaxA:
16.95