SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5yay KINESIN-LIKE PROTEIN
KIF21A
KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		4 / 7 LEU B1165
ALA A1212
LEU A1210
SER A1177
 None
 0.71A 1dvxA-5yayB:
undetectable		 1dvxA-5yayB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		5 / 12 ILE A1255
SER A1251
LYS A1259
LEU A1293
LEU A1246
 None
 1.43A 1lbcA-5yayA:
undetectable
1lbcC-5yayA:
undetectable		 1lbcA-5yayA:
16.02
1lbcC-5yayA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		3 / 3 ALA A1139
VAL A1133
TRP A1130
 None
 0.88A 1nt6A-5yayA:
undetectable		 1nt6A-5yayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		3 / 3 ALA A1139
VAL A1133
TRP A1130
 None
 0.88A 1nt6B-5yayA:
undetectable		 1nt6B-5yayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		5 / 11 GLU A1318
ALA A1319
ILE A1324
ALA A1312
ASP A1323
 None
 1.27A 2admA-5yayA:
undetectable		 2admA-5yayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		4 / 5 LEU A1279
ALA A1316
ILE A1315
SER A1314
 None
 1.09A 2othA-5yayA:
undetectable		 2othA-5yayA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		5 / 11 LYS A1259
LEU A1293
LEU A1246
ILE A1255
SER A1251
 None
 1.44A 3h6tA-5yayA:
undetectable
3h6tC-5yayA:
undetectable		 3h6tA-5yayA:
16.02
3h6tC-5yayA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		5 / 11 ILE A1255
SER A1251
LYS A1259
LEU A1293
LEU A1246
 None
 1.47A 3h6tA-5yayA:
undetectable
3h6tC-5yayA:
undetectable		 3h6tA-5yayA:
16.02
3h6tC-5yayA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		3 / 3 ASP A1146
ARG A1090
TYR A1091
 None
 1.01A 5a7mA-5yayA:
undetectable		 5a7mA-5yayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
(Mus
musculus) 		3 / 3 ASP A1146
ARG A1090
TYR A1091
 None
 1.01A 5a7mB-5yayA:
undetectable		 5a7mB-5yayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5yay KN MOTIF AND ANKYRIN
REPEAT DOMAINS 1
KINESIN-LIKE PROTEIN
KIF21A
(Mus
musculus;
Mus
musculus) 		5 / 12 GLN A1200
GLY A1204
ARG B1156
ILE A1270
LEU A1246
 None
 1.13A 6c2mA-5yayA:
undetectable		 6c2mA-5yayA:
24.66