SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 PHE A 535
LEU A 328
ALA A 326
ALA A 325
ARG A  43
 None
 1.10A 1cbrA-5yb7A:
undetectable		 1cbrA-5yb7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 PHE A 535
LEU A 328
ALA A 326
ALA A 325
ARG A  43
 None
 1.10A 1cbrB-5yb7A:
undetectable		 1cbrB-5yb7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 LEU A 195
ASP A 200
MET A 251
LEU A 167
 None
 1.11A 1errB-5yb7A:
undetectable		 1errB-5yb7A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 HIS A 453
ASP A 377
ASP A 385
PRO A 373
 None
 1.29A 1ilqA-5yb7A:
undetectable
1ilqC-5yb7A:
undetectable		 1ilqA-5yb7A:
16.46
1ilqC-5yb7A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 ILE A  17
GLY A  19
PRO A  20
TYR A 488
GLN A 522
 None
 1.20A 1s9aB-5yb7A:
undetectable		 1s9aB-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A 502
ALA A 326
ILE A  50
ILE A 505
ILE A 531
 None
 1.01A 1sduB-5yb7A:
undetectable		 1sduB-5yb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 4 SER A 106
ILE A  15
VAL A 250
THR A 232
 None
 1.19A 1u70A-5yb7A:
undetectable		 1u70A-5yb7A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.45A 1v54A-5yb7A:
0.8
1v54B-5yb7A:
undetectable
1v54T-5yb7A:
undetectable		 1v54A-5yb7A:
undetectable
1v54B-5yb7A:
undetectable
1v54T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.50A 1v54G-5yb7A:
undetectable
1v54N-5yb7A:
0.2
1v54O-5yb7A:
undetectable		 1v54G-5yb7A:
undetectable
1v54N-5yb7A:
undetectable
1v54O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.47A 1v55G-5yb7A:
undetectable
1v55N-5yb7A:
undetectable
1v55O-5yb7A:
undetectable		 1v55G-5yb7A:
undetectable
1v55N-5yb7A:
undetectable
1v55O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 ALA A 472
GLY A 471
ALA A 515
ILE A 461
SER A 363
 FAD  A 601 (-3.4A)
None
ORN  A 602 ( 3.5A)
None
FAD  A 601 (-3.6A)
 1.15A 1ve3B-5yb7A:
undetectable		 1ve3B-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.50A 2dyrG-5yb7A:
undetectable
2dyrN-5yb7A:
0.2
2dyrO-5yb7A:
undetectable		 2dyrG-5yb7A:
undetectable
2dyrN-5yb7A:
undetectable
2dyrO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.47A 2eijG-5yb7A:
undetectable
2eijN-5yb7A:
undetectable
2eijO-5yb7A:
undetectable		 2eijG-5yb7A:
undetectable
2eijN-5yb7A:
undetectable
2eijO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 SER A 364
ARG A 433
LEU A 436
HIS A 428
 None
 1.29A 2f8dA-5yb7A:
undetectable		 2f8dA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A  57
GLY A  52
THR A 330
GLU A  75
ASP A 508
ILE A  55
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
FAD  A 601 (-4.8A)
 1.49A 2pxcA-5yb7A:
undetectable		 2pxcA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 THR A 337
CYH A 331
VAL A  51
THR A 329
LEU A 346
 ORN  A 603 (-3.0A)
FAD  A 601 (-4.6A)
FAD  A 601 (-4.4A)
None
None
 1.15A 2qo5A-5yb7A:
undetectable		 2qo5A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		3 / 3 HIS A 490
MET A 496
MET A 351
 None
 1.18A 2vj1A-5yb7A:
undetectable		 2vj1A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_G_CHDG1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.49A 2y69G-5yb7A:
undetectable
2y69N-5yb7A:
0.5
2y69O-5yb7A:
undetectable		 2y69G-5yb7A:
undetectable
2y69N-5yb7A:
undetectable
2y69O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.46A 2y69A-5yb7A:
undetectable
2y69B-5yb7A:
undetectable
2y69T-5yb7A:
undetectable		 2y69A-5yb7A:
undetectable
2y69B-5yb7A:
undetectable
2y69T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		3 / 3 TYR A  74
VAL A 314
THR A 299
 None
 0.88A 2ygnA-5yb7A:
undetectable		 2ygnA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.43A 2zxwA-5yb7A:
undetectable
2zxwB-5yb7A:
undetectable
2zxwT-5yb7A:
undetectable		 2zxwA-5yb7A:
undetectable
2zxwB-5yb7A:
undetectable
2zxwT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.42A 2zxwG-5yb7A:
undetectable
2zxwN-5yb7A:
undetectable
2zxwO-5yb7A:
undetectable		 2zxwG-5yb7A:
undetectable
2zxwN-5yb7A:
undetectable
2zxwO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 GLU A 223
GLY A 233
PHE A 156
LEU A 152
THR A 135
 None
 1.27A 3a3yA-5yb7A:
2.0		 3a3yA-5yb7A:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.47A 3abkA-5yb7A:
undetectable
3abkB-5yb7A:
undetectable
3abkT-5yb7A:
undetectable		 3abkA-5yb7A:
undetectable
3abkB-5yb7A:
undetectable
3abkT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.44A 3ablA-5yb7A:
undetectable
3ablB-5yb7A:
undetectable
3ablT-5yb7A:
undetectable		 3ablA-5yb7A:
undetectable
3ablB-5yb7A:
undetectable
3ablT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.49A 3ablG-5yb7A:
undetectable
3ablN-5yb7A:
undetectable
3ablO-5yb7A:
undetectable		 3ablG-5yb7A:
undetectable
3ablN-5yb7A:
undetectable
3ablO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.46A 3abmA-5yb7A:
0.8
3abmB-5yb7A:
undetectable
3abmT-5yb7A:
undetectable		 3abmA-5yb7A:
undetectable
3abmB-5yb7A:
undetectable
3abmT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.48A 3abmG-5yb7A:
undetectable
3abmN-5yb7A:
0.6
3abmO-5yb7A:
undetectable		 3abmG-5yb7A:
undetectable
3abmN-5yb7A:
undetectable
3abmO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.42A 3ag1A-5yb7A:
undetectable
3ag1B-5yb7A:
undetectable
3ag1T-5yb7A:
undetectable		 3ag1A-5yb7A:
undetectable
3ag1B-5yb7A:
undetectable
3ag1T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_G_CHDG86_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.49A 3ag2G-5yb7A:
undetectable
3ag2N-5yb7A:
0.3
3ag2O-5yb7A:
undetectable		 3ag2G-5yb7A:
undetectable
3ag2N-5yb7A:
undetectable
3ag2O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.45A 3ag4A-5yb7A:
undetectable
3ag4B-5yb7A:
undetectable
3ag4T-5yb7A:
undetectable		 3ag4A-5yb7A:
undetectable
3ag4B-5yb7A:
undetectable
3ag4T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.46A 3ag4G-5yb7A:
undetectable
3ag4N-5yb7A:
undetectable
3ag4O-5yb7A:
undetectable		 3ag4G-5yb7A:
undetectable
3ag4N-5yb7A:
undetectable
3ag4O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.45A 3asnA-5yb7A:
0.6
3asnB-5yb7A:
undetectable
3asnT-5yb7A:
undetectable		 3asnA-5yb7A:
undetectable
3asnB-5yb7A:
undetectable
3asnT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_G_CHDG229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.50A 3asnG-5yb7A:
undetectable
3asnN-5yb7A:
0.8
3asnO-5yb7A:
undetectable		 3asnG-5yb7A:
undetectable
3asnN-5yb7A:
undetectable
3asnO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.44A 3asoA-5yb7A:
0.9
3asoB-5yb7A:
undetectable
3asoT-5yb7A:
undetectable		 3asoA-5yb7A:
undetectable
3asoB-5yb7A:
undetectable
3asoT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 5 ASP A 457
ILE A 412
ILE A 459
GLY A 456
 None
 0.78A 3bufA-5yb7A:
undetectable		 3bufA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A 502
ALA A 326
ILE A  50
VAL A  51
ILE A 505
ILE A 531
 None
None
None
FAD  A 601 (-4.4A)
None
None
 1.19A 3ekqA-5yb7A:
undetectable		 3ekqA-5yb7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 VAL A 268
ILE A  50
VAL A 521
VAL A 517
LEU A  83
 None
None
None
FAD  A 601 (-3.9A)
FAD  A 601 (-4.1A)
 1.00A 3gwxA-5yb7A:
undetectable		 3gwxA-5yb7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 PHE A 402
TYR A 400
CYH A 413
PHE A 124
 None
 1.23A 3ltwA-5yb7A:
undetectable		 3ltwA-5yb7A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A 502
ALA A 326
ILE A  50
ILE A 505
ILE A 531
 None
 1.00A 3ndxA-5yb7A:
undetectable		 3ndxA-5yb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 TYR A 400
GLY A 398
THR A 399
LEU A 414
 None
 0.98A 3ps9A-5yb7A:
3.7		 3ps9A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		3 / 3 PHE A 491
GLN A 495
PHE A  22
 None
 0.76A 3rv5A-5yb7A:
undetectable		 3rv5A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A 502
ALA A 326
ILE A  50
ILE A 505
ILE A 531
 None
 1.04A 3tkgC-5yb7A:
undetectable		 3tkgC-5yb7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.41A 3wg7A-5yb7A:
undetectable
3wg7B-5yb7A:
undetectable
3wg7T-5yb7A:
undetectable		 3wg7A-5yb7A:
undetectable
3wg7B-5yb7A:
undetectable
3wg7T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.45A 3wg7G-5yb7A:
undetectable
3wg7N-5yb7A:
undetectable
3wg7O-5yb7A:
undetectable		 3wg7G-5yb7A:
undetectable
3wg7N-5yb7A:
undetectable
3wg7O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.44A 3x2qA-5yb7A:
undetectable
3x2qB-5yb7A:
undetectable
3x2qT-5yb7A:
undetectable		 3x2qA-5yb7A:
undetectable
3x2qB-5yb7A:
undetectable
3x2qT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.46A 3x2qG-5yb7A:
undetectable
3x2qN-5yb7A:
undetectable
3x2qO-5yb7A:
undetectable		 3x2qG-5yb7A:
undetectable
3x2qN-5yb7A:
undetectable
3x2qO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A  57
GLY A  52
THR A 330
GLU A  75
ASP A 508
ILE A  55
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
FAD  A 601 (-4.8A)
 1.46A 4ctkA-5yb7A:
2.1		 4ctkA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 7 ILE A 461
TRP A 463
PHE A 469
GLU A 464
 None
FAD  A 601 (-3.9A)
FAD  A 601 (-4.3A)
None
 1.49A 4nosC-5yb7A:
undetectable
4nosD-5yb7A:
undetectable		 4nosC-5yb7A:
10.87
4nosD-5yb7A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 ASN A 543
ALA A 109
ALA A  25
TRP A  29
GLN A 522
 None
 1.39A 4ryaA-5yb7A:
undetectable		 4ryaA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A  90
ASN A  89
ALA A  96
GLN A  86
ASP A 457
 None
 1.26A 4ubeA-5yb7A:
3.2		 4ubeA-5yb7A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 9 PRO A 277
LEU A 117
MET A  65
SER A 288
LEU A 289
 None
 1.17A 4x3mB-5yb7A:
undetectable		 4x3mB-5yb7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 8 ASP A 238
PHE A 239
VAL A 228
ASP A 236
 ORN  A 602 (-3.1A)
None
None
None
 1.11A 4xqgA-5yb7A:
2.1		 4xqgA-5yb7A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 8 ASP A 238
PHE A 239
VAL A 228
ASP A 236
 ORN  A 602 (-3.1A)
None
None
None
 1.09A 4xqgB-5yb7A:
3.1		 4xqgB-5yb7A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.45A 5b1aA-5yb7A:
undetectable
5b1aB-5yb7A:
undetectable
5b1aT-5yb7A:
undetectable		 5b1aA-5yb7A:
undetectable
5b1aB-5yb7A:
undetectable
5b1aT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.46A 5b1aG-5yb7A:
undetectable
5b1aN-5yb7A:
0.5
5b1aO-5yb7A:
undetectable		 5b1aG-5yb7A:
undetectable
5b1aN-5yb7A:
undetectable
5b1aO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A  57
GLY A  52
THR A 330
GLU A  75
ASP A 508
ILE A  55
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
FAD  A 601 (-4.8A)
 1.45A 5eifA-5yb7A:
undetectable		 5eifA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A  57
GLY A  52
THR A 330
GLU A  75
ASP A 508
ILE A  55
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
FAD  A 601 (-4.8A)
 1.44A 5eiwC-5yb7A:
undetectable		 5eiwC-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		6 / 12 GLY A  57
GLY A  52
THR A 330
GLU A  75
ASP A 508
ILE A  55
 None
FAD  A 601 (-3.2A)
None
FAD  A 601 (-2.8A)
FAD  A 601 (-3.2A)
FAD  A 601 (-4.8A)
 1.46A 5kqrA-5yb7A:
undetectable		 5kqrA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.45A 5wauA-5yb7A:
undetectable
5wauB-5yb7A:
undetectable
5waug-5yb7A:
undetectable		 5wauA-5yb7A:
undetectable
5wauB-5yb7A:
undetectable
5waug-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.43A 5x19A-5yb7A:
undetectable
5x19B-5yb7A:
undetectable
5x19T-5yb7A:
undetectable		 5x19A-5yb7A:
undetectable
5x19B-5yb7A:
undetectable
5x19T-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.44A 5x19G-5yb7A:
undetectable
5x19N-5yb7A:
undetectable
5x19O-5yb7A:
undetectable		 5x19G-5yb7A:
undetectable
5x19N-5yb7A:
undetectable
5x19O-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.38A 5x1bA-5yb7A:
undetectable
5x1bB-5yb7A:
undetectable
5x1bT-5yb7A:
undetectable		 5x1bA-5yb7A:
undetectable
5x1bB-5yb7A:
undetectable
5x1bT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.42A 5x1bG-5yb7A:
undetectable
5x1bN-5yb7A:
undetectable
5x1bO-5yb7A:
undetectable		 5x1bG-5yb7A:
undetectable
5x1bN-5yb7A:
undetectable
5x1bO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.46A 5x1fA-5yb7A:
0.0
5x1fB-5yb7A:
undetectable
5x1fT-5yb7A:
undetectable		 5x1fA-5yb7A:
undetectable
5x1fB-5yb7A:
undetectable
5x1fT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.41A 5x1fG-5yb7A:
undetectable
5x1fN-5yb7A:
undetectable
5x1fO-5yb7A:
undetectable		 5x1fG-5yb7A:
undetectable
5x1fN-5yb7A:
undetectable
5x1fO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.41A 5xdqA-5yb7A:
undetectable
5xdqB-5yb7A:
undetectable
5xdqT-5yb7A:
undetectable		 5xdqA-5yb7A:
undetectable
5xdqB-5yb7A:
undetectable
5xdqT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.40A 5xdqG-5yb7A:
undetectable
5xdqN-5yb7A:
0.6
5xdqO-5yb7A:
undetectable		 5xdqG-5yb7A:
undetectable
5xdqN-5yb7A:
undetectable
5xdqO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.43A 5xdxA-5yb7A:
undetectable
5xdxB-5yb7A:
undetectable
5xdxT-5yb7A:
undetectable		 5xdxA-5yb7A:
undetectable
5xdxB-5yb7A:
undetectable
5xdxT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_O_CHDO301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.42A 5xdxG-5yb7A:
undetectable
5xdxN-5yb7A:
undetectable
5xdxO-5yb7A:
undetectable		 5xdxG-5yb7A:
undetectable
5xdxN-5yb7A:
undetectable
5xdxO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.46A 5zcoA-5yb7A:
0.8
5zcoB-5yb7A:
undetectable
5zcoT-5yb7A:
undetectable		 5zcoA-5yb7A:
undetectable
5zcoB-5yb7A:
undetectable
5zcoT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.44A 5zcoG-5yb7A:
undetectable
5zcoN-5yb7A:
undetectable
5zcoO-5yb7A:
undetectable		 5zcoG-5yb7A:
undetectable
5zcoN-5yb7A:
undetectable
5zcoO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 GLY A 519
GLU A 518
THR A  16
THR A 252
PHE A  22
 None
 1.47A 5zcpA-5yb7A:
undetectable
5zcpB-5yb7A:
undetectable
5zcpT-5yb7A:
undetectable		 5zcpA-5yb7A:
undetectable
5zcpB-5yb7A:
undetectable
5zcpT-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 10 PHE A  22
GLY A 519
GLU A 518
THR A  16
THR A 252
 None
 1.46A 5zcpG-5yb7A:
undetectable
5zcpN-5yb7A:
0.6
5zcpO-5yb7A:
undetectable		 5zcpG-5yb7A:
undetectable
5zcpN-5yb7A:
undetectable
5zcpO-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		4 / 6 SER A 237
ALA A 422
ALA A 472
SER A 363
 ORN  A 602 ( 4.4A)
None
FAD  A 601 (-3.4A)
FAD  A 601 (-3.6A)
 1.02A 6bocA-5yb7A:
undetectable
6bocB-5yb7A:
undetectable
6bocC-5yb7A:
undetectable
6bocD-5yb7A:
undetectable		 6bocA-5yb7A:
undetectable
6bocB-5yb7A:
undetectable
6bocC-5yb7A:
undetectable
6bocD-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 12 GLY A 263
VAL A 261
PHE A 110
GLY A  80
GLY A  81
 None
None
None
None
FAD  A 601 (-3.0A)
 0.97A 6brdB-5yb7A:
10.4		 6brdB-5yb7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		5 / 11 ASP A  21
THR A 513
LEU A 188
VAL A 196
TYR A 481
 None
 1.25A 6dryA-5yb7A:
undetectable		 6dryA-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E
(Pseudomonas
sp.
AIU
813) 		3 / 3 ARG A 359
PHE A 473
GLY A 475
 None
ORN  A 602 (-4.6A)
None
 0.69A 6fgdA-5yb7A:
3.9		 6fgdA-5yb7A:
undetectable