SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ybb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
3 / 3 TRP A 414
VAL A 352
TRP A 417
None
0.94A 1gmkC-5ybbA:
undetectable
1gmkD-5ybbA:
undetectable
1gmkC-5ybbA:
4.08
1gmkD-5ybbA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 7 PHE A 373
PHE A 347
VAL A 276
HIS A 308
None
0.99A 1lh6A-5ybbA:
undetectable
1lh6A-5ybbA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 LEU A  87
PHE A  90
ALA A  89
LEU A 129
None
0.79A 1ukbA-5ybbA:
undetectable
1ukbA-5ybbA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 5 ILE A  68
SER A 113
ARG A 100
LEU A 102
None
1.01A 1y0xX-5ybbA:
undetectable
1y0xX-5ybbA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_B_H4BB920_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 TRP A  39
GLU A  35
ARG A 100
VAL A 122
None
1.41A 1zvlA-5ybbA:
undetectable
1zvlB-5ybbA:
undetectable
1zvlA-5ybbA:
20.49
1zvlB-5ybbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
3 / 3 PRO D 143
THR D  81
PRO D  83
None
0.48A 2d55C-5ybbD:
undetectable
2d55C-5ybbD:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 VAL A 153
ARG A   7
LEU A  10
PHE A 148
None
1.35A 2f8dA-5ybbA:
undetectable
2f8dA-5ybbA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
4 / 8 TYR D  39
CYH D 100
THR D  80
THR D  81
None
1.01A 2fb2A-5ybbD:
undetectable
2fb2A-5ybbD:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 7 MET A  21
LEU A  41
VAL A 153
TRP A  15
None
1.30A 2hrcA-5ybbA:
undetectable
2hrcA-5ybbA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 12 ALA A 197
GLY A 199
ASN A 279
PRO A 281
PHE A 305
SAM  A 601 (-3.0A)
SAM  A 601 (-3.3A)
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
0.47A 2okcA-5ybbA:
34.2
2okcA-5ybbA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 12 ALA A 197
GLY A 199
ASN A 279
PRO A 281
PHE A 305
SAM  A 601 (-3.0A)
SAM  A 601 (-3.3A)
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
0.45A 2okcB-5ybbA:
35.5
2okcB-5ybbA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
5 / 11 PHE D 252
ASP D 251
GLN D 267
ILE D 295
VAL D 279
None
1.23A 2vcdA-5ybbD:
undetectable
2vcdA-5ybbD:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 8 ARG A 175
GLY A 169
PRO A 238
GLY A 242
SAM  A 601 ( 4.2A)
None
SAM  A 601 ( 4.8A)
None
0.90A 2y6rB-5ybbA:
2.5
2y6rB-5ybbA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 7 GLU A 462
ARG A 457
GLU A 386
SER A 354
None
1.17A 2zt7A-5ybbA:
undetectable
2zt7A-5ybbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 8 THR A 359
LEU A 389
GLU A 327
SER A 354
None
0.92A 2zw9A-5ybbA:
undetectable
2zw9A-5ybbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 5 VAL A 181
VAL A 182
GLN A 188
PHE A 373
None
1.15A 3bjwH-5ybbA:
undetectable
3bjwH-5ybbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 VAL A 181
VAL A 182
GLN A 188
PHE A 373
None
1.16A 3bjwF-5ybbA:
undetectable
3bjwF-5ybbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 5 VAL A 181
VAL A 182
GLN A 188
PHE A 373
None
1.24A 3bjwB-5ybbA:
undetectable
3bjwB-5ybbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 12 THR A 173
PHE A 407
VAL A 353
ALA A 369
THR A 351
SAM  A 601 (-3.2A)
None
None
None
None
1.26A 3dl9B-5ybbA:
undetectable
3dl9B-5ybbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT
RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus;
Caldanaerobacter
subterraneus)
3 / 3 ASN D 287
ASP D 254
ARG A 375
None
0.83A 3k13A-5ybbD:
undetectable
3k13A-5ybbD:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 TYR A 363
VAL A 177
THR A 173
PHE A 282
None
None
SAM  A 601 (-3.2A)
None
1.21A 3ltwA-5ybbA:
undetectable
3ltwA-5ybbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 5 LEU A  43
TYR A  33
MET A  21
ARG A 112
None
1.19A 4bkjB-5ybbA:
undetectable
4bkjB-5ybbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 9 PRO A 295
GLN A 297
LEU A 304
LEU A 262
ILE A 266
None
None
None
SAM  A 601 ( 4.2A)
None
1.40A 4c66A-5ybbA:
undetectable
4c66A-5ybbA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
4 / 6 GLU A 462
ARG A 457
GLU A 386
SER A 354
None
1.25A 4kr3A-5ybbA:
undetectable
4kr3A-5ybbA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
4 / 8 ASN D 110
ARG D 111
LEU D 119
ILE D 155
None
1.08A 4l7iA-5ybbD:
undetectable
4l7iA-5ybbD:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
4 / 6 CYH D 100
ILE D  99
GLN D  98
ILE D  52
None
1.19A 4z4dA-5ybbD:
undetectable
4z4dA-5ybbD:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
3 / 3 THR A 173
ASP A 195
GLU A 233
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.7A)
0.74A 5fa8A-5ybbA:
10.8
5fa8A-5ybbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
3 / 3 LYS D  51
ASP D  46
ARG D 124
None
1.02A 5jwaA-5ybbD:
undetectable
5jwaH-5ybbD:
undetectable
5jwaA-5ybbD:
21.02
5jwaH-5ybbD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
4 / 6 PRO D 257
PRO D 244
LEU D 243
PHE D 245
None
1.05A 5tl8A-5ybbD:
undetectable
5tl8A-5ybbD:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus)
5 / 12 SER D  47
VAL D 177
ALA D  89
VAL D 167
LEU D 390
None
1.24A 5tudD-5ybbD:
undetectable
5tudD-5ybbD:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
12 / 12 ALA A 197
GLY A 199
THR A 200
CYH A 201
GLY A 202
LYS A 234
LYS A 235
PRO A 238
THR A 261
LEU A 262
ASN A 279
PHE A 305
SAM  A 601 (-3.0A)
SAM  A 601 (-3.3A)
SAM  A 601 (-4.4A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.0A)
SAM  A 601 (-4.7A)
None
SAM  A 601 ( 4.8A)
SAM  A 601 (-3.8A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.7A)
SAM  A 601 (-4.7A)
0.10A 5ybbA-5ybbA:
61.7
5ybbA-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 5 PHE A 171
THR A 173
ASP A 195
GLU A 233
ASN A 260
None
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.7A)
SAM  A 601 (-2.9A)
0.00A 5ybbA-5ybbA:
61.7
5ybbA-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
5 / 12 ASP A 195
LYS A 235
ASN A 279
PRO A 281
PHE A 305
SAM  A 601 (-3.5A)
None
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
0.97A 5ybbB-5ybbA:
59.0
5ybbB-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
11 / 12 THR A 173
ARG A 175
ASP A 195
THR A 200
CYH A 201
LYS A 234
PRO A 238
LEU A 262
ASN A 279
PRO A 281
PHE A 305
SAM  A 601 (-3.2A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.4A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.7A)
SAM  A 601 ( 4.8A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
0.12A 5ybbB-5ybbA:
59.0
5ybbB-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus)
7 / 7 PHE A 171
ALA A 197
GLY A 199
GLY A 202
GLU A 233
ASN A 260
THR A 261
None
SAM  A 601 (-3.0A)
SAM  A 601 (-3.3A)
SAM  A 601 (-3.0A)
SAM  A 601 (-2.7A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.8A)
0.21A 5ybbB-5ybbA:
59.0
5ybbB-5ybbA:
100.00