SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ybl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1501_1 (CYTOCHROME P450 3A4)	5ybl	MULTIFUNCTIONAL DIOXYGENASE AUSE (Aspergillus nidulans)	5 / 10	ASP A 91 ARG A 259 PHE A 231 LEU A 96 ILE A 248	None	1.33A	2v0mA-5yblA: undetectable	2v0mA-5yblA: 10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_1 (GLYCINE N-METHYLTRANSFERASE)	5ybl	MULTIFUNCTIONAL DIOXYGENASE AUSE (Aspergillus nidulans)	3 / 3	LEU A 97 HIS A 94 MET A 93	None	0.89A	3thrD-5yblA: undetectable	3thrD-5yblA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXC_A_ZITA307_1 (PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	5ybl	MULTIFUNCTIONAL DIOXYGENASE AUSE (Aspergillus nidulans)	4 / 5	ASP A 204 GLU A 119 ARG A 226 THR A 158	None None AKG A 302 (-3.0A) None	1.44A	5uxcA-5yblA: undetectable	5uxcA-5yblA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5ybl	MULTIFUNCTIONAL DIOXYGENASE AUSE (Aspergillus nidulans)	3 / 3	THR A 260 GLU A 89 HIS A 85	None	0.91A	5xiqD-5yblA: undetectable	5xiqD-5yblA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_A_KLNA1501_1","CYTOCHROME P450 3A4","5ybl","MULTIFUNCTIONAL DIOXYGENASE AUSE","Aspergillus nidulans",5,"ASP A  91;ARG A 259;PHE A 231;LEU A  96;ILE A 248","None","1.33A","2v0mA-5yblA:undetectable","2v0mA-5yblA:10.50"],["3THR_A_C2FA1100_1","GLYCINE N-METHYLTRANSFERASE","5ybl","MULTIFUNCTIONAL DIOXYGENASE AUSE","Aspergillus nidulans",3,"LEU A  97;HIS A  94;MET A  93","None","0.89A","3thrD-5yblA:undetectable","3thrD-5yblA:undetectable"],["5UXC_A_ZITA307_1","PREDICTED AMINOGLYCOSIDE PHOSPHOTRANSFERASE","5ybl","MULTIFUNCTIONAL DIOXYGENASE AUSE","Aspergillus nidulans",4,"ASP A 204;GLU A 119;ARG A 226;THR A 158","None;None;AKG A 302 (-3.0A);None","1.44A","5uxcA-5yblA:undetectable","5uxcA-5yblA:18.03"],["5XIQ_D_HFGD1002_1","PROLYL-TRNA SYNTHETASE (PRORS)","5ybl","MULTIFUNCTIONAL DIOXYGENASE AUSE","Aspergillus nidulans",3,"THR A 260;GLU A  89;HIS A  85","None","0.91A","5xiqD-5yblA:undetectable","5xiqD-5yblA:undetectable"]]