SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ybp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 11 GLY A 146
SER A 141
GLY A 210
GLN A 133
ILE A 233
 None
 1.26A 1jzsA-5ybpA:
undetectable		 1jzsA-5ybpA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5ybp PRHA
(Penicillium
brasilianum) 		4 / 8 SER A 257
HIS A  94
PHE A 112
VAL A  77
 None
 1.00A 1kb9A-5ybpA:
undetectable
1kb9C-5ybpA:
undetectable
1kb9D-5ybpA:
undetectable
1kb9E-5ybpA:
undetectable		 1kb9A-5ybpA:
undetectable
1kb9C-5ybpA:
undetectable
1kb9D-5ybpA:
undetectable
1kb9E-5ybpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 MET A  93
LEU A 231
MET A 256
PHE A 112
ILE A 233
 None
 1.22A 1xotA-5ybpA:
undetectable		 1xotA-5ybpA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ybp PRHA
(Penicillium
brasilianum) 		4 / 8 SER A 260
VAL A 248
PHE A  83
ASN A 115
 None
 1.19A 2wekA-5ybpA:
undetectable		 2wekA-5ybpA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ybp PRHA
(Penicillium
brasilianum) 		4 / 8 SER A 260
VAL A 248
PHE A  83
ASN A 115
 None
 1.19A 2wekB-5ybpA:
undetectable		 2wekB-5ybpA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 LEU A 231
PHE A 112
ILE A 233
SER A  90
LEU A  92
 None
 1.25A 3n8xA-5ybpA:
undetectable		 3n8xA-5ybpA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 LEU A  92
LEU A  96
CYH A  97
ILE A  33
PHE A  22
 None
 0.89A 4a7aB-5ybpA:
undetectable		 4a7aB-5ybpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5ybp PRHA
(Penicillium
brasilianum) 		4 / 8 ASN A 152
ASP A 132
PHE A 154
HIS A 214
 None
FE  A 301 ( 2.5A)
AKG  A 302 (-4.4A)
FE  A 301 ( 3.2A)
 1.16A 4f5zA-5ybpA:
undetectable		 4f5zA-5ybpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 LEU A 150
PHE A  25
LEU A 207
GLY A  29
SER A 232
 None
 1.15A 4zbrA-5ybpA:
undetectable		 4zbrA-5ybpA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 PHE A 244
PHE A 160
TYR A 206
ALA A 166
ALA A 216
 None
None
None
None
AKG  A 302 (-3.3A)
 1.09A 5tl8A-5ybpA:
undetectable		 5tl8A-5ybpA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 PHE A 244
PHE A 160
TYR A 206
ALA A 166
THR A  70
 None
 1.25A 5tl8A-5ybpA:
undetectable		 5tl8A-5ybpA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ybp PRHA
(Penicillium
brasilianum) 		5 / 12 SER A 232
ILE A  88
LEU A 238
LEU A 150
TYR A 136
 None
 1.32A 5ycpA-5ybpA:
undetectable		 5ycpA-5ybpA:
20.93