SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		3 / 3 GLU A 331
TYR A 366
PHE A 351
 None
 0.86A 1eqbB-5yc1A:
undetectable		 1eqbB-5yc1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		3 / 3 GLU A 331
TYR A 366
PHE A 351
 None
 0.84A 1eqbA-5yc1A:
undetectable		 1eqbA-5yc1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		3 / 3 GLU A 331
TYR A 366
PHE A 351
 None
 0.85A 1eqbD-5yc1A:
undetectable		 1eqbD-5yc1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		3 / 3 GLU A 331
TYR A 366
PHE A 351
 None
 0.84A 1eqbC-5yc1A:
undetectable		 1eqbC-5yc1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		5 / 11 PRO A 401
ASP A 392
LEU A 390
VAL A 456
ALA A 455
 None
 1.14A 3n23C-5yc1A:
undetectable		 3n23C-5yc1A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		4 / 6 VAL A 309
LEU A 390
SER A 389
ILE A 440
 None
 0.86A 5jw1A-5yc1A:
undetectable		 5jw1A-5yc1A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		4 / 6 GLU A 301
PHE A 337
THR A 339
TYR A 338
 None
 1.24A 5lrbA-5yc1A:
undetectable		 5lrbA-5yc1A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4
(Homo
sapiens) 		5 / 12 TYR A 317
ILE A 445
LEU A 390
ALA A 350
LEU A 365
 None
 1.36A 5zwrB-5yc1A:
undetectable		 5zwrB-5yc1A:
18.07