SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5yd5 SCFV 4B08
(Mus
musculus) 		4 / 7 GLN A   8
SER A   9
TYR A  96
GLN A 183
 None
 1.37A 1eiiA-5yd5A:
undetectable		 1eiiA-5yd5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5yd5 SCFV 4B08
(Mus
musculus) 		6 / 12 TYR A 239
PHE A 243
TRP A  35
VAL A  39
ALA A  99
TRP A 109
 None
 0.68A 1h8sA-5yd5A:
22.0		 1h8sA-5yd5A:
47.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5yd5 SCFV 4B08
(Mus
musculus) 		3 / 3 SER A 245
THR A 242
PHE A  66
 None
 0.75A 2x91A-5yd5A:
undetectable		 2x91A-5yd5A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5yd5 SCFV 4B08
(Mus
musculus) 		4 / 5 THR A 217
SER A 208
SER A 221
ARG A 219
 None
None
SO4  A 303 (-2.8A)
SO4  A 303 (-3.8A)
 1.21A 3hlwB-5yd5A:
undetectable		 3hlwB-5yd5A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5yd5 SCFV 4B08
(Mus
musculus) 		4 / 6 ARG A 184
PHE A 207
PRO A 204
LEU A 192
 None
 1.34A 3tgvD-5yd5A:
undetectable		 3tgvD-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5yd5 SCFV 4B08
(Mus
musculus) 		5 / 11 GLN A 235
VAL A  39
TYR A  97
PRO A 189
LEU A  47
 None
 1.46A 5jh7B-5yd5A:
undetectable		 5jh7B-5yd5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5yd5 SCFV 4B08
(Mus
musculus) 		5 / 12 VAL A 153
VAL A 203
GLN A 187
ILE A 193
PHE A 207
 None
 1.32A 6becA-5yd5A:
undetectable
6becB-5yd5A:
2.6
6becC-5yd5A:
undetectable		 6becA-5yd5A:
10.28
6becB-5yd5A:
10.28
6becC-5yd5A:
10.28