SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ydj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 9 TRP A 245
GLY A 278
TRP A 592
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
SEB  A 360 ( 4.2A)
None
 0.91A 1acjA-5ydjA:
65.6		 1acjA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 TRP A 245
GLY A 279
GLU A 359
TYR A 493
TRP A 592
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.51A 1acjA-5ydjA:
65.6		 1acjA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 10 TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.39A 1aclA-5ydjA:
66.0		 1aclA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 TRP A 245
GLY A 278
GLU A 359
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.3A)
SEB  A 360 ( 4.2A)
 0.93A 1ax9A-5ydjA:
60.2		 1ax9A-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
 0.37A 1ax9A-5ydjA:
60.2		 1ax9A-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 PHE A 449
ALA A 361
PHE A 490
LEU A 384
GLN A 385
 None
SEB  A 360 ( 3.7A)
None
None
None
 1.41A 1brpA-5ydjA:
undetectable		 1brpA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
GLY A 280
TYR A 282
TRP A 393
PHE A 449
PHE A 490
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
None
None
None
SEB  A 360 ( 4.2A)
 0.40A 1dx6A-5ydjA:
65.7		 1dx6A-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 10 GLY A 280
TYR A 282
TRP A 441
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 3.0A)
None
None
None
None
SEB  A 360 ( 4.2A)
 1.15A 1eveA-5ydjA:
66.7		 1eveA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 10 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
LEU A 444
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SO4  A 816 (-4.0A)
None
None
SEB  A 360 ( 4.2A)
 0.73A 1eveA-5ydjA:
66.7		 1eveA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 368
LEU A 371
SER A 367
HIS A 600
PHE A 449
 None
None
None
SEB  A 360 ( 4.2A)
None
 1.20A 1fmlA-5ydjA:
undetectable		 1fmlA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 368
LEU A 371
SER A 367
HIS A 600
PHE A 449
 None
None
None
SEB  A 360 ( 4.2A)
None
 1.19A 1fmlB-5ydjA:
undetectable		 1fmlB-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 ARG A 548
VAL A 505
ASN A 547
ASP A 549
 None
 1.32A 1hwiC-5ydjA:
undetectable		 1hwiC-5ydjA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 ARG A 548
VAL A 505
ASN A 547
ASP A 549
 None
 1.32A 1hwiD-5ydjA:
undetectable		 1hwiD-5ydjA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLY A 358
ALA A 382
SER A 365
HIS A 369
LEU A 371
 None
 1.31A 1kiaD-5ydjA:
undetectable		 1kiaD-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 12 ASP A 233
GLY A 280
TYR A 282
GLU A 359
TRP A 441
TYR A 489
TYR A 493
HIS A 600
 None
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
None
SEB  A 360 ( 4.2A)
 1.17A 1maaA-5ydjA:
55.1		 1maaA-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 ASP A 233
TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
PHE A 449
TYR A 489
TYR A 493
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
None
None
SEB  A 360 ( 4.2A)
 0.60A 1maaA-5ydjA:
55.1		 1maaA-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 GLU A 511
ILE A 492
TYR A 488
GLY A 487
 None
 0.87A 1maaB-5ydjA:
63.3
1maaD-5ydjA:
55.1		 1maaB-5ydjA:
9.14
1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 TRP A 245
TYR A 282
GLU A 359
ILE A 446
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
 0.69A 1maaB-5ydjA:
63.3
1maaD-5ydjA:
55.1		 1maaB-5ydjA:
9.14
1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 TRP A 245
TYR A 282
GLU A 359
TYR A 493
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
 0.57A 1maaB-5ydjA:
63.3
1maaD-5ydjA:
55.1		 1maaB-5ydjA:
9.14
1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 280
TYR A 282
TRP A 441
TYR A 489
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 3.0A)
None
None
None
None
None
SEB  A 360 ( 4.2A)
 1.19A 1maaC-5ydjA:
59.9		 1maaC-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
None
SEB  A 360 ( 4.2A)
 0.92A 1maaC-5ydjA:
59.9		 1maaC-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 279
TYR A 282
TYR A 291
TRP A 441
PHE A 449
TYR A 489
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
None
None
None
None
None
None
SEB  A 360 ( 4.2A)
 0.63A 1maaC-5ydjA:
59.9		 1maaC-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 GLY A 280
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 1.20A 1maaD-5ydjA:
55.1		 1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 8 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.56A 1maaD-5ydjA:
55.1		 1maaD-5ydjA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 ASP A 233
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 None
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
 1.08A 1qtiA-5ydjA:
61.5		 1qtiA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
GLY A 280
TYR A 282
GLU A 359
PHE A 449
PHE A 490
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.38A 1qtiA-5ydjA:
61.5		 1qtiA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 278
GLY A 279
GLY A 280
GLU A 359
PHE A 490
PHE A 449
HIS A 600
 SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 1.03A 1qtiA-5ydjA:
61.5		 1qtiA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
TYR A 282
GLU A 359
TRP A 441
LEU A 444
HIS A 600
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
SO4  A 816 (-4.0A)
SEB  A 360 ( 4.2A)
 0.84A 1u65A-5ydjA:
62.1		 1u65A-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 11 TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.44A 1u65A-5ydjA:
62.1		 1u65A-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 12 ASP A 233
TRP A 245
GLY A 278
GLY A 279
GLY A 280
TYR A 282
PHE A 449
PHE A 490
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
None
None
SEB  A 360 ( 4.2A)
 0.38A 1w6rA-5ydjA:
65.7		 1w6rA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 278
GLY A 279
GLY A 280
PHE A 490
PHE A 449
HIS A 600
 SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
None
SEB  A 360 ( 4.2A)
 1.13A 1w6rA-5ydjA:
65.7		 1w6rA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 11 ASP A 233
TRP A 245
GLY A 279
GLY A 280
TYR A 282
GLU A 359
PHE A 449
PHE A 490
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.45A 1w76A-5ydjA:
63.5		 1w76A-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		9 / 10 ASP A 233
TRP A 245
GLY A 278
GLY A 279
TYR A 282
GLU A 359
PHE A 449
PHE A 490
HIS A 600
 None
SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 0.37A 1w76B-5ydjA:
63.4		 1w76B-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 330
HIS A 369
LEU A 274
GLY A 358
PHE A 281
 None
 1.18A 1xwfA-5ydjA:
undetectable		 1xwfA-5ydjA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 330
HIS A 369
LEU A 274
GLY A 358
PHE A 281
 None
 1.21A 1xwfD-5ydjA:
undetectable		 1xwfD-5ydjA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 9 GLY A 279
GLY A 280
ALA A 361
PHE A 490
PHE A 449
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.7A)
None
None
SEB  A 360 ( 4.2A)
 1.20A 2aceA-5ydjA:
66.4		 2aceA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 9 GLY A 279
GLY A 280
ALA A 361
TRP A 393
PHE A 449
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.7A)
None
None
SEB  A 360 ( 4.2A)
 0.42A 2aceA-5ydjA:
66.4		 2aceA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 7 TRP A 245
GLY A 278
GLU A 359
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.3A)
SEB  A 360 ( 4.2A)
 0.94A 2ackA-5ydjA:
65.2		 2ackA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 7 TRP A 245
GLY A 279
TYR A 282
GLU A 359
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
 0.45A 2ackA-5ydjA:
65.2		 2ackA-5ydjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 8 ASP A 233
TRP A 245
TYR A 282
TRP A 441
TYR A 489
TYR A 493
HIS A 600
 None
SEB  A 360 ( 4.2A)
None
None
None
None
SEB  A 360 ( 4.2A)
 0.75A 2ha2A-5ydjA:
26.1		 2ha2A-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 ASP A 233
TRP A 245
TYR A 282
TRP A 441
TYR A 493
HIS A 600
 None
SEB  A 360 ( 4.2A)
None
None
None
SEB  A 360 ( 4.2A)
 0.62A 2ha2B-5ydjA:
63.6		 2ha2B-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 8 ASP A 233
TRP A 245
TYR A 282
TYR A 489
TYR A 493
HIS A 600
 None
SEB  A 360 ( 4.2A)
None
None
None
SEB  A 360 ( 4.2A)
 0.84A 2ha2B-5ydjA:
63.6		 2ha2B-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 8 TRP A 245
TYR A 282
TYR A 291
GLU A 359
TYR A 489
PHE A 490
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
None
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.38A 2ha4A-5ydjA:
59.7		 2ha4A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 7 TRP A 245
TYR A 282
TYR A 291
GLU A 359
TYR A 489
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
None
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
None
 0.38A 2ha4B-5ydjA:
64.6		 2ha4B-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 7 GLY A 279
GLY A 280
ALA A 361
TRP A 393
PHE A 449
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.7A)
None
None
SEB  A 360 ( 4.2A)
 0.47A 2ha4B-5ydjA:
64.6		 2ha4B-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 ASP A 233
TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 489
TYR A 493
 None
SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
None
None
 0.73A 2ha6A-5ydjA:
59.9		 2ha6A-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
 None
 0.76A 2ha6A-5ydjA:
59.9		 2ha6A-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
GLU A 610
LEU A 616
TYR A 618
 None
 1.20A 2ha6A-5ydjA:
59.9		 2ha6A-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		8 / 9 TRP A 245
TYR A 282
TRP A 441
TYR A 489
PHE A 490
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
None
None
None
None
None
SEB  A 360 ( 4.2A)
None
 0.73A 2ha6B-5ydjA:
63.4		 2ha6B-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
ASP A 289
LEU A 616
TYR A 618
 None
 0.84A 2ha6B-5ydjA:
63.4		 2ha6B-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 10 MET A 244
ASN A 246
GLU A 610
LEU A 616
TYR A 618
 None
 1.17A 2ha6B-5ydjA:
63.4		 2ha6B-5ydjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLY A 481
ASN A 565
LEU A 680
VAL A 674
TYR A 664
 None
 1.41A 2nyrB-5ydjA:
undetectable		 2nyrB-5ydjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 LEU A 384
ALA A 363
LEU A 371
LEU A 395
PHE A 560
 None
SEB  A 360 ( 3.3A)
None
None
None
 1.39A 2oaxF-5ydjA:
undetectable		 2oaxF-5ydjA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 6 TRP A 245
TYR A 282
TRP A 441
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
None
None
None
SEB  A 360 ( 4.2A)
 0.61A 2xudA-5ydjA:
55.2		 2xudA-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 SER A 587
GLU A 610
ASP A 602
 None
 0.80A 3bwmA-5ydjA:
undetectable		 3bwmA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 SER A 587
GLU A 610
ASP A 602
 None
 0.76A 3bwyA-5ydjA:
undetectable		 3bwyA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 TYR A 309
GLU A 359
ASP A 602
 None
SEB  A 360 ( 3.3A)
None
 0.83A 3bxoA-5ydjA:
undetectable		 3bxoA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 PHE A 490
CYH A 447
PHE A 449
 None
 0.91A 3cr5X-5ydjA:
1.8		 3cr5X-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 TRP A 191
ILE A 194
TRP A 339
VAL A 340
 None
 1.50A 3deuA-5ydjA:
undetectable		 3deuA-5ydjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 VAL A 564
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
None
SEB  A 360 ( 4.1A)
SEB  A 360 ( 3.3A)
None
 0.93A 3hs6A-5ydjA:
undetectable		 3hs6A-5ydjA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 GLU A 486
GLY A 279
ALA A 242
ASP A 602
ASN A 246
 None
SEB  A 360 ( 3.0A)
None
None
None
 1.39A 3jzjA-5ydjA:
undetectable		 3jzjA-5ydjA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ALA A 324
GLY A 320
LEU A 317
THR A 402
ALA A 405
 None
 0.92A 3kw2A-5ydjA:
undetectable		 3kw2A-5ydjA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ALA A 324
GLY A 320
LEU A 317
THR A 402
ALA A 405
 None
 0.91A 3kw2B-5ydjA:
undetectable		 3kw2B-5ydjA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 7 GLY A 279
GLY A 280
TRP A 393
PHE A 560
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
None
SEB  A 360 ( 4.2A)
 0.43A 3o9mA-5ydjA:
65.9		 3o9mA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 GLY A 279
GLY A 280
TRP A 393
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 4.2A)
 0.49A 3o9mB-5ydjA:
65.9		 3o9mB-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 258
TYR A 196
ALA A 286
LEU A 337
ALA A 382
 None
 1.26A 3ozuA-5ydjA:
2.5		 3ozuA-5ydjA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ALA A 328
GLY A 329
TYR A 309
ALA A 197
TYR A 196
 None
 1.22A 3qxyB-5ydjA:
undetectable
3qxyQ-5ydjA:
undetectable		 3qxyB-5ydjA:
undetectable
3qxyQ-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ALA A 328
GLY A 329
TYR A 309
ALA A 197
TYR A 196
 None
 1.20A 3rc0A-5ydjA:
undetectable		 3rc0A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ALA A 328
GLY A 329
TYR A 309
ALA A 197
TYR A 196
 None
 1.18A 3rc0B-5ydjA:
undetectable		 3rc0B-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 5 TYR A 282
VAL A 311
SER A 283
GLY A 278
 None
None
SEB  A 360 ( 4.6A)
SEB  A 360 ( 3.5A)
 1.45A 3v4tA-5ydjA:
undetectable
3v4tD-5ydjA:
undetectable		 3v4tA-5ydjA:
undetectable
3v4tD-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 4 LEU A 690
ILE A 446
TYR A 522
TYR A 535
 None
 1.44A 3vt7A-5ydjA:
undetectable		 3vt7A-5ydjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 THR A 390
ASN A 563
GLY A 387
ILE A 478
 None
None
SEB  A 360 ( 4.0A)
None
 0.90A 3w9tF-5ydjA:
undetectable		 3w9tF-5ydjA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BDS_A_THAA701_1
(CHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 TRP A 245
GLU A 359
TYR A 493
TRP A 592
MET A 599
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.3A)
None
None
None
SEB  A 360 ( 4.2A)
None
 0.70A 4bdsA-5ydjA:
63.4		 4bdsA-5ydjA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 PHE A 379
TYR A 581
GLY A 362
ALA A 363
LEU A 370
 None
None
SEB  A 360 ( 4.1A)
SEB  A 360 ( 3.3A)
None
 0.92A 4e1gA-5ydjA:
undetectable		 4e1gA-5ydjA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 278
GLY A 279
GLY A 280
PHE A 490
PHE A 449
HIS A 600
 SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
None
SEB  A 360 ( 4.2A)
 1.18A 4ey6A-5ydjA:
63.8		 4ey6A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		6 / 12 GLY A 279
TYR A 282
SER A 283
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 4.6A)
None
None
SEB  A 360 ( 4.2A)
 1.15A 4ey6A-5ydjA:
63.8		 4ey6A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 278
GLY A 279
GLY A 280
TYR A 282
SER A 283
PHE A 449
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 4.6A)
None
None
None
SEB  A 360 ( 4.2A)
 0.47A 4ey6A-5ydjA:
63.8		 4ey6A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
None
SEB  A 360 ( 4.2A)
 0.86A 4ey6A-5ydjA:
63.8		 4ey6A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 12 GLY A 278
GLY A 279
GLY A 280
GLU A 359
PHE A 490
PHE A 449
HIS A 600
 SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
 1.12A 4ey6B-5ydjA:
55.6		 4ey6B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		10 / 12 TRP A 245
GLY A 278
GLY A 279
GLY A 280
TYR A 282
GLU A 359
PHE A 449
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
None
None
SEB  A 360 ( 4.2A)
 0.48A 4ey6B-5ydjA:
55.6		 4ey6B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TRP A 245
GLY A 278
TYR A 489
PHE A 490
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
None
SEB  A 360 ( 4.2A)
 0.87A 4ey6B-5ydjA:
55.6		 4ey6B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 TRP A 245
GLY A 278
TYR A 489
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
SEB  A 360 ( 4.2A)
None
 0.72A 4ey7A-5ydjA:
63.6		 4ey7A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
GLU A 359
TRP A 441
TYR A 489
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.75A 4ey7A-5ydjA:
63.6		 4ey7A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
GLU A 359
TYR A 489
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.95A 4ey7A-5ydjA:
63.6		 4ey7A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
None
 0.53A 4ey7A-5ydjA:
63.6		 4ey7A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
None
 0.58A 4ey7A-5ydjA:
63.6		 4ey7A-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 TRP A 245
GLY A 278
TYR A 489
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.5A)
None
SEB  A 360 ( 4.2A)
None
 0.72A 4ey7B-5ydjA:
60.0		 4ey7B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
GLU A 359
TRP A 441
TYR A 489
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.75A 4ey7B-5ydjA:
60.0		 4ey7B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
GLU A 359
TYR A 489
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.95A 4ey7B-5ydjA:
60.0		 4ey7B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
None
 0.52A 4ey7B-5ydjA:
60.0		 4ey7B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 11 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
None
 0.58A 4ey7B-5ydjA:
60.0		 4ey7B-5ydjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 11 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 0.93A 4g1bB-5ydjA:
undetectable		 4g1bB-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 9 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 0.92A 4g1bC-5ydjA:
undetectable		 4g1bC-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 478
THR A 480
TYR A 581
LEU A 384
VAL A 366
 None
 0.95A 4g1bD-5ydjA:
undetectable		 4g1bD-5ydjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 HIS A 559
GLY A 445
ILE A 446
 None
 0.64A 4k50A-5ydjA:
undetectable		 4k50A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 HIS A 559
GLY A 445
ILE A 446
 None
 0.63A 4k50I-5ydjA:
undetectable		 4k50I-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ARG A 266
GLY A 348
ASP A 189
PRO A 263
 None
 1.12A 4lajA-5ydjA:
undetectable
4lajB-5ydjA:
undetectable		 4lajA-5ydjA:
11.78
4lajB-5ydjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 TYR A 583
HIS A 600
GLU A 486
GLU A 359
LEU A 296
 None
SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
 1.33A 4r7lA-5ydjA:
undetectable		 4r7lA-5ydjA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 344
GLY A 349
PRO A 267
PHE A 347
VAL A 272
 None
 1.11A 4rvdA-5ydjA:
2.2		 4rvdA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 ILE A 344
GLY A 349
PRO A 267
PHE A 347
VAL A 272
 None
 1.09A 4rvgA-5ydjA:
undetectable		 4rvgA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ALA A 197
GLN A 198
LEU A 256
LEU A 204
 None
 1.14A 4xp3A-5ydjA:
undetectable		 4xp3A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 VAL A 598
GLU A 486
GLY A 487
TYR A 489
ILE A 446
 None
 1.33A 4xucA-5ydjA:
undetectable		 4xucA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 12 VAL A 598
GLU A 486
GLY A 487
TYR A 489
ILE A 446
 None
 1.32A 4xudA-5ydjA:
undetectable		 4xudA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 SER A 587
GLU A 610
ASP A 602
 None
 0.82A 4xudA-5ydjA:
undetectable		 4xudA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ASN A 565
ASP A 557
THR A 480
VAL A 564
 None
 0.99A 4yoaA-5ydjA:
undetectable		 4yoaA-5ydjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 6 ASP A 233
TYR A 282
TRP A 441
TYR A 493
 None
 0.45A 5e2iA-5ydjA:
65.5		 5e2iA-5ydjA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		7 / 9 TRP A 245
TYR A 282
GLU A 359
TRP A 441
TYR A 493
HIS A 600
GLY A 601
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
None
SEB  A 360 ( 4.2A)
None
 0.47A 5e4jA-5ydjA:
66.4		 5e4jA-5ydjA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		3 / 3 ASP A 456
ARG A 210
ARG A 310
 None
 0.98A 5eajB-5ydjA:
undetectable		 5eajB-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 PHE A 239
GLY A 241
TRP A 245
ASP A 602
 None
None
SEB  A 360 ( 4.2A)
None
 0.88A 5gqbA-5ydjA:
undetectable		 5gqbA-5ydjA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		4 / 8 GLY A 362
SER A 306
ALA A 286
PHE A 277
 SEB  A 360 ( 4.1A)
None
None
None
 0.66A 5xu8A-5ydjA:
undetectable		 5xu8A-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 5 TRP A 245
TYR A 291
GLU A 359
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
None
SEB  A 360 ( 3.3A)
None
SEB  A 360 ( 4.2A)
 0.61A 6ep4A-5ydjA:
66.2		 6ep4A-5ydjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5ydj ACETYLCHOLINESTERASE
(Anopheles
gambiae) 		5 / 8 TRP A 245
GLY A 280
TRP A 393
PHE A 490
TYR A 493
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
None
None
 0.62A 6eqpA-5ydjA:
undetectable		 6eqpA-5ydjA:
24.10