SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ydl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 12 ARG A 265
GLN A  95
GLU A 152
GLY A 349
GLY A 347
 None
 1.24A 1httB-5ydlA:
undetectable		 1httB-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 12 ARG A 265
GLN A  95
GLU A 152
GLY A 349
GLY A 347
 None
 1.22A 1httD-5ydlA:
undetectable		 1httD-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 12 LEU A 227
GLY A 207
SER A 272
ARG A 263
ASP A 243
 None
 1.10A 2br4F-5ydlA:
undetectable		 2br4F-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 8 ILE A 188
VAL A 150
TYR A 177
CYH A 181
 None
 1.27A 2xz5A-5ydlA:
undetectable
2xz5C-5ydlA:
undetectable		 2xz5A-5ydlA:
undetectable
2xz5C-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 8 ILE A 188
VAL A 150
TYR A 177
CYH A 181
 None
 1.28A 2xz5C-5ydlA:
undetectable
2xz5D-5ydlA:
undetectable		 2xz5C-5ydlA:
undetectable
2xz5D-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 5 ARG A 130
LEU A 133
VAL A 150
ASP A 128
 None
 1.18A 3ufnA-5ydlA:
undetectable
3ufnB-5ydlA:
undetectable		 3ufnA-5ydlA:
17.54
3ufnB-5ydlA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 10 LEU A  88
ILE A 346
ILE A 170
GLY A 171
GLY A 175
 None
 1.01A 4fakA-5ydlA:
undetectable		 4fakA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 4 THR A 353
GLU A 345
ARG A 357
HIS A 373
 None
 1.23A 4hvcA-5ydlA:
undetectable		 4hvcA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 5 THR A 353
GLU A 345
ARG A 357
HIS A 373
 None
 1.23A 4hvcB-5ydlA:
undetectable		 4hvcB-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 4 THR A 353
GLU A 345
ARG A 357
HIS A 373
 None
 1.25A 4olfA-5ydlA:
undetectable		 4olfA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 LEU A 254
ARG A 263
VAL A 247
LEU A 227
LEU A 222
 None
 1.28A 4or0B-5ydlA:
undetectable		 4or0B-5ydlA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.50A 4qvlV-5ydlA:
undetectable
4qvlb-5ydlA:
undetectable		 4qvlV-5ydlA:
15.09
4qvlb-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.50A 4qvlH-5ydlA:
undetectable
4qvlN-5ydlA:
undetectable		 4qvlH-5ydlA:
15.09
4qvlN-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 9 ALA A 230
THR A 325
ALA A 231
VAL A 274
ALA A 270
 None
None
None
None
DUV  A 501 ( 4.1A)
 1.01A 4qvnK-5ydlA:
undetectable
4qvnL-5ydlA:
undetectable		 4qvnK-5ydlA:
18.89
4qvnL-5ydlA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 9 ALA A 230
THR A 325
ALA A 231
VAL A 274
ALA A 270
 None
None
None
None
DUV  A 501 ( 4.1A)
 1.01A 4qvnY-5ydlA:
undetectable
4qvnZ-5ydlA:
undetectable		 4qvnY-5ydlA:
18.89
4qvnZ-5ydlA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.49A 4qvpH-5ydlA:
undetectable
4qvpN-5ydlA:
undetectable		 4qvpH-5ydlA:
15.09
4qvpN-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 10 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.49A 4qvvH-5ydlA:
0.0
4qvvN-5ydlA:
undetectable		 4qvvH-5ydlA:
15.09
4qvvN-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.47A 4qvyV-5ydlA:
undetectable
4qvyb-5ydlA:
undetectable		 4qvyV-5ydlA:
15.09
4qvyb-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.47A 4qvyH-5ydlA:
undetectable
4qvyN-5ydlA:
undetectable		 4qvyH-5ydlA:
15.09
4qvyN-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 8 ALA A  71
ALA A  67
ALA A  64
ALA A  21
 None
 0.81A 4twdF-5ydlA:
undetectable
4twdG-5ydlA:
undetectable
4twdH-5ydlA:
undetectable
4twdI-5ydlA:
undetectable
4twdJ-5ydlA:
undetectable		 4twdF-5ydlA:
15.46
4twdG-5ydlA:
15.46
4twdH-5ydlA:
15.46
4twdI-5ydlA:
15.46
4twdJ-5ydlA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 12 ARG A 265
GLN A  95
GLU A 152
GLY A 349
GLY A 347
 None
 1.23A 5e3iA-5ydlA:
undetectable		 5e3iA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 ARG A 265
GLN A  95
GLU A 152
GLY A 349
GLY A 347
 None
 1.22A 5e3iB-5ydlA:
undetectable		 5e3iB-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		3 / 3 THR A 308
ASP A 309
ALA A 310
 None
 0.07A 5g5gB-5ydlA:
undetectable		 5g5gB-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.48A 5l5fV-5ydlA:
undetectable
5l5fb-5ydlA:
0.0		 5l5fV-5ydlA:
15.09
5l5fb-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 HIS A 273
SER A 228
THR A 244
ALA A 241
THR A 239
 None
 1.48A 5l5fH-5ydlA:
undetectable
5l5fN-5ydlA:
undetectable		 5l5fH-5ydlA:
15.09
5l5fN-5ydlA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 6 TYR A 153
LEU A  89
GLY A 175
PHE A 149
 None
 0.92A 5nooC-5ydlA:
undetectable		 5nooC-5ydlA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 11 LEU A  36
SER A  59
LEU A   5
VAL A  56
ALA A  40
 None
 1.04A 5o96A-5ydlA:
undetectable
5o96B-5ydlA:
undetectable		 5o96A-5ydlA:
undetectable
5o96B-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 10 ILE A 346
GLY A 347
GLY A 349
VAL A 383
LEU A 384
 None
 1.06A 5o96C-5ydlA:
undetectable
5o96D-5ydlA:
undetectable		 5o96C-5ydlA:
undetectable
5o96D-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 4 THR A 353
GLU A 345
ARG A 357
HIS A 373
 None
 1.15A 5xiqA-5ydlA:
0.0		 5xiqA-5ydlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 12 ASP A  37
GLY A  41
ALA A  40
LEU A  24
LEU A  28
 None
 1.02A 5xxiA-5ydlA:
undetectable		 5xxiA-5ydlA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		5 / 9 THR A  94
GLY A  93
GLY A  92
HIS A 172
VAL A 326
 None
None
DUV  A 501 (-4.2A)
None
None
 1.43A 6gnfA-5ydlA:
undetectable		 6gnfA-5ydlA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 5ydl PKS
(Streptomyces
sp.
CNQ431) 		4 / 4 THR A 353
GLU A 345
ARG A 357
HIS A 373
 None
 1.37A 6mn8A-5ydlA:
undetectable		 6mn8A-5ydlA:
undetectable