SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 VAL A 263
GLY A 266
GLY A 128
THR A 132
ALA A 133
 None
 1.13A 1jg4A-5yemA:
2.4		 1jg4A-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 4 ARG A 511
LEU A 477
ASN A 479
VAL A 508
 None
 1.43A 1lqtA-5yemA:
3.2		 1lqtA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 4 ARG A 511
LEU A 477
ASN A 479
VAL A 508
 None
 1.45A 1lqtB-5yemA:
3.3		 1lqtB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 4 ARG A 511
LEU A 477
ASN A 479
VAL A 508
 None
 1.43A 1lquA-5yemA:
5.2		 1lquA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 4 ARG A 511
LEU A 477
ASN A 479
VAL A 508
 None
 1.45A 1lquB-5yemA:
undetectable		 1lquB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 6 PHE A 382
ASN A 377
ASN A 396
GLN A 404
 None
 1.19A 1t9uA-5yemA:
undetectable		 1t9uA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 HIS A 229
ASP A 306
ASN A 456
 HEM  A 704 (-3.8A)
None
None
 0.81A 1wg8B-5yemA:
4.2		 1wg8B-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 ALA A 599
GLY A 606
GLY A 553
ILE A 634
LEU A 579
 None
 0.98A 1x1aA-5yemA:
3.3		 1x1aA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 8 PHE A 271
ALA A 254
HIS A 222
LEU A 550
 None
 1.11A 1x8vA-5yemA:
undetectable		 1x8vA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 THR A 102
ILE A 294
VAL A 292
ILE A 354
LEU A 324
 None
 1.14A 1z9hD-5yemA:
undetectable		 1z9hD-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 TRP A 277
THR A 340
TYR A 336
 None
 1.28A 2a3aA-5yemA:
undetectable		 2a3aA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 GLY A 642
VAL A 668
GLY A 646
ASP A 637
PHE A 635
 None
 1.14A 2f8lA-5yemA:
2.0		 2f8lA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 7 LEU A 171
LEU A 207
ALA A 210
PHE A 188
 None
 0.89A 2vcvG-5yemA:
2.3		 2vcvG-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 ALA A 638
PHE A 677
GLY A 667
ARG A 693
LEU A 685
 None
 1.42A 3aodC-5yemA:
undetectable		 3aodC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 ASN A 284
ALA A 279
ASP A 605
THR A 132
GLU A 260
 None
 1.16A 3ckkA-5yemA:
4.1		 3ckkA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 ARG A 689
VAL A 263
THR A 602
 None
 0.76A 3cyxA-5yemA:
undetectable		 3cyxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 5 ASN A 284
ASP A 275
GLU A 260
SER A 282
 None
 1.47A 3p2kC-5yemA:
2.3		 3p2kC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 PHE A 247
GLN A 251
PHE A 143
 None
 0.83A 3rv5A-5yemA:
undetectable		 3rv5A-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 5 PHE A 197
PHE A 188
ALA A 187
LEU A 171
 None
 1.11A 3t3zC-5yemA:
undetectable		 3t3zC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 8 HIS A  82
ASP A 135
ASN A 155
ILE A 157
 HEM  A 704 (-3.3A)
None
HEM  A 704 (-3.3A)
None
 1.05A 4k0bA-5yemA:
undetectable		 4k0bA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 6 GLY A 154
ASP A 151
PRO A 347
ARG A 365
 HEM  A 704 (-3.9A)
None
None
HEM  A 704 (-3.5A)
 1.15A 4lajA-5yemA:
undetectable
4lajB-5yemA:
undetectable		 4lajA-5yemA:
undetectable
4lajB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 6 GLY A 227
ASP A 151
PRO A 347
ARG A 365
 None
None
None
HEM  A 704 (-3.5A)
 0.94A 4lajA-5yemA:
undetectable
4lajB-5yemA:
undetectable		 4lajA-5yemA:
undetectable
4lajB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 TRP A 209
GLN A 163
THR A 206
 None
 1.04A 4m2xA-5yemA:
undetectable		 4m2xA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.13A 4rrwA-5yemA:
1.4		 4rrwA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.13A 4rrwB-5yemA:
undetectable		 4rrwB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.10A 4rrxA-5yemA:
undetectable		 4rrxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.10A 4rrxB-5yemA:
undetectable		 4rrxB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.13A 4rrzA-5yemA:
1.4		 4rrzA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.13A 4rrzB-5yemA:
undetectable		 4rrzB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 6 LEU A 362
ASP A 359
TYR A 369
LEU A 366
 None
None
HEM  A 704 (-3.8A)
None
 0.98A 4wozA-5yemA:
undetectable
4wozB-5yemA:
undetectable		 4wozA-5yemA:
undetectable
4wozB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 5 LEU A 362
ASP A 359
TYR A 369
LEU A 366
 None
None
HEM  A 704 (-3.8A)
None
 1.03A 4wozF-5yemA:
undetectable
4wozH-5yemA:
undetectable		 4wozF-5yemA:
undetectable
4wozH-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 7 MET A 204
PHE A 208
ALA A 480
LEU A 477
 None
 1.06A 4xk8A-5yemA:
undetectable		 4xk8A-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 276
ASP A 330
ILE A 280
GLY A 285
LEU A 327
 None
 0.96A 4y8wA-5yemA:
undetectable		 4y8wA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 276
ASP A 330
ILE A 280
GLY A 285
LEU A 327
 None
 0.98A 4y8wB-5yemA:
undetectable		 4y8wB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 7 MET A 223
HIS A  82
GLY A 154
ASN A 155
 None
HEM  A 704 (-3.3A)
HEM  A 704 (-3.9A)
HEM  A 704 (-3.3A)
 1.36A 5a5zC-5yemA:
undetectable		 5a5zC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 6 PHE A 466
PHE A 305
SER A 505
VAL A 504
 None
 1.23A 5hesA-5yemA:
undetectable		 5hesA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.30A 5iktB-5yemA:
undetectable		 5iktB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 8 ARG A 482
ASN A 479
GLN A 474
ASP A 507
 None
 1.23A 5vunA-5yemA:
undetectable		 5vunA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		4 / 5 THR A 357
ARG A 232
THR A 454
ASP A 457
 None
 1.26A 6ecxA-5yemA:
undetectable		 6ecxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5yem CATALASE
(Mycothermus
thermophilus) 		3 / 3 ARG A 689
PHE A 690
GLY A 642
 None
 0.70A 6fgdA-5yemA:
4.8		 6fgdA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 VAL A 123
VAL A 136
ASP A 170
PHE A 168
PHE A 160
 None
None
None
HEM  A 704 (-3.6A)
HEM  A 704 (-3.7A)
 1.47A 6iblA-5yemA:
3.9		 6iblA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5yem CATALASE
(Mycothermus
thermophilus) 		5 / 12 VAL A 123
VAL A 136
ASP A 170
PHE A 168
PHE A 160
 None
None
None
HEM  A 704 (-3.6A)
HEM  A 704 (-3.7A)
 1.48A 6iblB-5yemA:
3.8		 6iblB-5yemA:
undetectable