SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY
(Shewanella
oneidensis) 		3 / 3 GLN B  44
ILE B   4
HIS B  56
 None
 0.72A 1fm9A-5yepB:
undetectable		 1fm9A-5yepB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY
(Shewanella
oneidensis) 		3 / 3 GLN B  44
ILE B   4
HIS B  56
 None
 0.72A 1k74A-5yepB:
undetectable		 1k74A-5yepB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5yep TOXIN-ANTITOXIN
SYSTEM ANTIDOTE MNT
FAMILY
TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY
(Shewanella
oneidensis) 		4 / 7 GLU A 101
MET A 110
LYS A 106
ARG B  59
 None
 1.20A 2hs1B-5yepA:
undetectable		 2hs1B-5yepA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5yep TOXIN-ANTITOXIN
SYSTEM ANTIDOTE MNT
FAMILY
(Shewanella
oneidensis) 		4 / 8 VAL A  86
TYR A  29
ILE A  42
GLN A  31
 None
 0.98A 3remA-5yepA:
undetectable		 3remA-5yepA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5yep TOXIN-ANTITOXIN
SYSTEM ANTIDOTE MNT
FAMILY
(Shewanella
oneidensis) 		4 / 8 VAL A  86
TYR A  29
ILE A  42
GLN A  31
 None
 0.95A 3remB-5yepA:
undetectable		 3remB-5yepA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5yep TOXIN-ANTITOXIN
SYSTEM TOXIN HEPN
FAMILY
(Shewanella
oneidensis) 		4 / 6 ILE B  19
LEU B 120
ARG B  97
MET B  93
 None
 1.03A 3wg7A-5yepB:
undetectable
3wg7J-5yepB:
undetectable		 3wg7A-5yepB:
undetectable
3wg7J-5yepB:
undetectable