SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  24
GLY A  26
SER A  27
ALA A  31
VAL A  89
 None
 1.21A 1i9gA-5yeqA:
4.9		 1i9gA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A 101
VAL A 168
VAL A  20
ALA A  21
LEU A  36
 None
 1.00A 1vptA-5yeqA:
undetectable		 1vptA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  24
GLY A  29
LEU A  81
PRO A  82
ILE A  85
 None
 0.98A 1zq9B-5yeqA:
2.7		 1zq9B-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		4 / 6 LEU A  23
GLN A  86
ILE A  85
PRO A  82
 None
 1.03A 2fcnA-5yeqA:
undetectable
2fcnB-5yeqA:
undetectable		 2fcnA-5yeqA:
undetectable
2fcnB-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		4 / 4 VAL A  94
ARG A  87
ILE A 112
THR A  67
 None
 1.35A 3cl9A-5yeqA:
undetectable		 3cl9A-5yeqA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 166
ALA A 149
ILE A 172
VAL A 137
GLY A 146
 None
 0.87A 3ebzB-5yeqA:
undetectable		 3ebzB-5yeqA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  34
GLY A  26
GLY A  29
LEU A  81
ALA A  57
 SO4  A 504 (-4.6A)
None
None
None
None
 1.06A 3i5uA-5yeqA:
4.4		 3i5uA-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  34
GLY A  26
GLY A  29
LEU A  81
ALA A  57
 SO4  A 504 (-4.6A)
None
None
None
None
 1.10A 3i5uB-5yeqA:
5.3		 3i5uB-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 GLY A  24
GLY A  29
ILE A  78
LEU A  81
PRO A  82
 None
 0.87A 4gc9A-5yeqA:
undetectable		 4gc9A-5yeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 9 ALA A 169
ALA A 165
VAL A 147
GLY A 178
ALA A 149
 None
 1.02A 4qvnK-5yeqA:
undetectable
4qvnL-5yeqA:
undetectable		 4qvnK-5yeqA:
17.92
4qvnL-5yeqA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 9 ALA A 169
ALA A 165
VAL A 147
GLY A 178
ALA A 149
 None
 1.03A 4qvnY-5yeqA:
undetectable
4qvnZ-5yeqA:
undetectable		 4qvnY-5yeqA:
17.92
4qvnZ-5yeqA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 GLU A 181
VAL A 151
ASP A   9
ALA A 169
PRO A 130
 None
 1.27A 5syeB-5yeqA:
undetectable		 5syeB-5yeqA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5yeq KETOL-ACID
REDUCTOISOMERASE
(NADP(+))
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  36
VAL A  20
ALA A  70
TRP A  32
ALA A  21
 None
 1.21A 5tzoB-5yeqA:
undetectable		 5tzoB-5yeqA:
18.79