SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.09A 1dz4A-5yewB:
undetectable		 1dz4A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.06A 1dz4B-5yewB:
undetectable		 1dz4B-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 SER B  86
SER B  89
GLY B 181
GLY B  82
 GDP  B 801 (-4.1A)
MG  B 804 ( 2.1A)
BEF  B 802 (-3.3A)
None
 0.73A 1f5lA-5yewB:
undetectable		 1f5lA-5yewB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 ILE B 108
GLY B 181
ASP B 178
GLY B  87
LEU B 212
 K  B 803 (-4.2A)
BEF  B 802 (-3.3A)
MG  B 804 ( 3.8A)
GDP  B 801 (-3.6A)
None
 1.08A 1kiaC-5yewB:
undetectable		 1kiaC-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 5 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.10A 1t88B-5yewB:
undetectable		 1t88B-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.04A 1yrcA-5yewB:
undetectable		 1yrcA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 SER B 284
ASP B 240
ARG B 253
GLU B 316
 GDP  B 801 (-3.1A)
GDP  B 801 (-3.0A)
None
None
 1.10A 2cdqB-5yewB:
undetectable		 2cdqB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.06A 2feuA-5yewB:
undetectable		 2feuA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.02A 2feuB-5yewB:
undetectable		 2feuB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 5 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.11A 2m56A-5yewB:
undetectable		 2m56A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 174
LEU B 176
GLN B 330
LEU B 235
VAL B  91
 None
 1.38A 2qd4A-5yewB:
2.1		 2qd4A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.15A 2zawA-5yewB:
undetectable		 2zawA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.06A 2zaxA-5yewB:
undetectable		 2zaxA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.09A 2zuhA-5yewB:
undetectable		 2zuhA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.09A 2zuiA-5yewB:
undetectable		 2zuiA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.05A 2zwuA-5yewB:
undetectable		 2zwuA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.04A 3fwfA-5yewB:
undetectable		 3fwfA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3fwfB-5yewB:
undetectable		 3fwfB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3fwgA-5yewB:
undetectable		 3fwgA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.04A 3fwgB-5yewB:
undetectable		 3fwgB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.05A 3fwjA-5yewB:
undetectable		 3fwjA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3l63A-5yewB:
undetectable		 3l63A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 VAL B  78
LEU B 176
PHE B 233
LEU B 235
 None
 0.81A 3qeoB-5yewB:
2.1		 3qeoB-5yewB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		3 / 3 ARG B  73
LYS B 336
ARG B  74
 None
 1.03A 3w1wA-5yewB:
2.6
3w1wB-5yewB:
3.0		 3w1wA-5yewB:
undetectable
3w1wB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		3 / 3 ARG B  74
ARG B  73
LYS B 336
 None
 1.11A 3w1wA-5yewB:
2.6
3w1wB-5yewB:
3.0		 3w1wA-5yewB:
undetectable
3w1wB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3wrhA-5yewB:
undetectable		 3wrhA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.02A 3wrhE-5yewB:
undetectable		 3wrhE-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.04A 3wrjA-5yewB:
undetectable		 3wrjA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.03A 3wrjE-5yewB:
undetectable		 3wrjE-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3wrlA-5yewB:
undetectable		 3wrlA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3wrlE-5yewB:
undetectable		 3wrlE-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 7 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.01A 3wrmA-5yewB:
undetectable		 3wrmA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.05A 4ek1A-5yewB:
undetectable		 4ek1A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.09A 4g3rA-5yewB:
undetectable		 4g3rA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.10A 4g3rB-5yewB:
undetectable		 4g3rB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.12A 4kkyX-5yewB:
undetectable		 4kkyX-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 5 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.08A 4l49A-5yewB:
undetectable		 4l49A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 6 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.10A 4l4cA-5yewB:
undetectable		 4l4cA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 PHE B 320
LEU B 176
VAL B  78
VAL B 205
 None
 1.05A 4l4dA-5yewB:
undetectable		 4l4dA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 GLU B 209
SER B 208
ARG B 313
ALA B 307
GLU B 287
 None
 1.30A 4mx0A-5yewB:
undetectable		 4mx0A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 GLU B  56
GLU B  37
LEU B  64
LEU B  25
ALA B 719
 None
 1.22A 4wcxC-5yewB:
3.3		 4wcxC-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 ILE B  18
LEU B  71
ILE B  21
LEU B 726
 None
 0.78A 4zvcA-5yewB:
4.5
4zvcB-5yewB:
4.4		 4zvcA-5yewB:
undetectable
4zvcB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 ILE B  21
LEU B 726
ILE B  18
LEU B  71
 None
 0.78A 4zvcA-5yewB:
4.5
4zvcB-5yewB:
4.4		 4zvcA-5yewB:
undetectable
4zvcB-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 GLU B 316
LEU B 204
LEU B 212
THR B 211
ARG B 313
 None
 1.40A 5hnxB-5yewB:
1.5		 5hnxB-5yewB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 5 SER B  90
SER B  89
SER B 103
SER B  85
 GDP  B 801 (-2.5A)
MG  B 804 ( 2.1A)
GDP  B 801 (-4.5A)
K  B 803 ( 2.9A)
 1.44A 5hswA-5yewB:
2.3		 5hswA-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		4 / 8 LEU B 235
VAL B 205
VAL B 203
MET B  95
 None
 0.70A 5y9mX-5yewB:
undetectable		 5y9mX-5yewB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 9 LEU B 235
VAL B 205
VAL B 203
MET B  95
ASP B 178
 None
None
None
None
MG  B 804 ( 3.8A)
 1.07A 5yf9X-5yewB:
undetectable		 5yf9X-5yewB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		3 / 3 SER B  89
LYS B  88
SER B  90
 MG  B 804 ( 2.1A)
BEF  B 802 ( 2.5A)
GDP  B 801 (-2.5A)
 0.83A 6az3P-5yewB:
undetectable		 6az3P-5yewB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens) 		5 / 12 ASP B 189
ILE B 192
SER B 179
PHE B  81
ASP B 183
 None
 1.33A 6fbpA-5yewB:
undetectable
6fbpB-5yewB:
undetectable		 6fbpA-5yewB:
22.62
6fbpB-5yewB:
22.62