SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 TYR A 154
ASP A 125
GLU A 127
PHE A 146
 None
 1.47A 1b2iA-5yfbA:
undetectable		 1b2iA-5yfbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 GLY A 318
TYR A 313
ALA A 321
GLU A 311
 None
None
None
GOL  A 804 (-3.1A)
 1.01A 1dmaB-5yfbA:
undetectable		 1dmaB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 LEU A  64
LEU A  67
LEU A  70
LEU A  98
TYR A 101
 None
 1.14A 1sqnB-5yfbA:
undetectable		 1sqnB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 TYR A 482
THR A 312
SER A 496
VAL A 491
 None
 1.11A 1tv8A-5yfbA:
undetectable		 1tv8A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.39A 1v7zA-5yfbA:
undetectable		 1v7zA-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.39A 1v7zB-5yfbA:
undetectable		 1v7zB-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.39A 1v7zC-5yfbA:
undetectable		 1v7zC-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.39A 1v7zD-5yfbA:
undetectable		 1v7zD-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.38A 1v7zE-5yfbA:
undetectable		 1v7zE-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 GLU A 501
HIS A 443
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 0.81A 1v7zF-5yfbA:
undetectable		 1v7zF-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 HIS A 288
ALA A 290
GLY A 283
LEU A 250
ASP A 245
 None
 1.02A 1x1aA-5yfbA:
undetectable		 1x1aA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 PHE A 550
ARG A 566
GLY A 116
ARG A 659
 None
None
None
GOL  A 803 (-4.1A)
 1.20A 2f7fA-5yfbA:
undetectable		 2f7fA-5yfbA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 TYR A 482
THR A 312
SER A 496
VAL A 491
 None
 1.14A 2fb2A-5yfbA:
undetectable		 2fb2A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 TYR A 482
THR A 312
SER A 496
VAL A 491
 None
 1.14A 2fb2B-5yfbA:
undetectable		 2fb2B-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 TYR A 482
VAL A 491
THR A 624
 None
 0.76A 2ygnA-5yfbA:
undetectable		 2ygnA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.34A 3a6jA-5yfbA:
undetectable		 3a6jA-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 GLU A 501
HIS A 443
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 0.79A 3a6jB-5yfbA:
undetectable		 3a6jB-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.34A 3a6jC-5yfbA:
undetectable		 3a6jC-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 8 GLU A 501
HIS A 443
HIS A 562
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 1.35A 3a6jE-5yfbA:
undetectable		 3a6jE-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 GLU A 501
HIS A 443
HIS A 448
GLU A 444
 ZN  A 801 (-2.0A)
ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
GOL  A 804 (-3.9A)
 0.78A 3a6jF-5yfbA:
undetectable		 3a6jF-5yfbA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 10 VAL A 611
VAL A 610
GLY A 607
LYS A 606
THR A 536
 None
 1.48A 3bjwD-5yfbA:
undetectable		 3bjwD-5yfbA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 PRO A 553
PHE A 550
LYS A 557
 None
 1.13A 3bjwG-5yfbA:
undetectable		 3bjwG-5yfbA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 TYR A 276
HIS A 288
ILE A 307
SER A 375
PHE A 326
 None
 1.11A 3g4lA-5yfbA:
undetectable		 3g4lA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 11 ASN A 442
LEU A 446
GLU A 359
ASN A 401
PHE A 399
 None
 1.32A 3jw5A-5yfbA:
undetectable		 3jw5A-5yfbA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 GLU A 359
ILE A 349
LEU A 615
LEU A 445
GLY A 449
 None
 1.10A 3k2hA-5yfbA:
undetectable		 3k2hA-5yfbA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 GLU A 359
ILE A 349
LEU A 615
LEU A 445
GLY A 449
 None
 1.05A 3k2hB-5yfbA:
undetectable		 3k2hB-5yfbA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 HIS A 443
GLU A 444
HIS A 448
 ZN  A 801 (-3.2A)
GOL  A 804 (-3.9A)
ZN  A 801 (-3.1A)
 0.22A 3kecB-5yfbA:
undetectable		 3kecB-5yfbA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 VAL A 277
ASN A 281
ALA A 291
ALA A 290
SER A 223
 None
 1.03A 3mteA-5yfbA:
undetectable		 3mteA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 TRP A 323
PHE A 280
GLU A 324
VAL A 310
 None
 1.35A 3nldA-5yfbA:
0.2
3nldB-5yfbA:
0.9		 3nldA-5yfbA:
12.01
3nldB-5yfbA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 9 LEU A 149
ILE A 121
ARG A 659
LEU A  68
VAL A 103
 None
None
GOL  A 803 (-4.1A)
None
None
 1.42A 3oxzA-5yfbA:
undetectable		 3oxzA-5yfbA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 PHE A 399
LEU A 352
VAL A 507
PHE A 363
ALA A 345
 None
 1.08A 3u9fD-5yfbA:
undetectable
3u9fE-5yfbA:
undetectable		 3u9fD-5yfbA:
undetectable
3u9fE-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 PHE A 399
LEU A 352
VAL A 507
PHE A 363
ALA A 345
 None
 1.16A 3u9fG-5yfbA:
undetectable
3u9fH-5yfbA:
undetectable		 3u9fG-5yfbA:
undetectable
3u9fH-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.02A 4a97E-5yfbA:
undetectable		 4a97E-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.04A 4a97C-5yfbA:
undetectable		 4a97C-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.00A 4a97D-5yfbA:
undetectable		 4a97D-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.01A 4a97G-5yfbA:
undetectable		 4a97G-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 1.02A 4a97H-5yfbA:
0.6		 4a97H-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 TYR A 313
VAL A 314
ILE A 164
GLU A 324
 None
 0.95A 4a97I-5yfbA:
undetectable		 4a97I-5yfbA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 GLY A 318
TYR A 313
ALA A 321
GLU A 311
 None
None
None
GOL  A 804 (-3.1A)
 0.83A 4hyfA-5yfbA:
undetectable		 4hyfA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 GLY A 318
TYR A 313
ALA A 321
GLU A 311
 None
None
None
GOL  A 804 (-3.1A)
 0.80A 4hyfB-5yfbA:
undetectable		 4hyfB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 GLY A 318
TYR A 313
ALA A 321
GLU A 311
 None
None
None
GOL  A 804 (-3.1A)
 0.80A 4hyfC-5yfbA:
undetectable		 4hyfC-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 ASP A 489
ARG A 394
THR A 312
 None
 0.61A 4i13A-5yfbA:
undetectable		 4i13A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 LEU A 341
VAL A 507
LEU A 615
LEU A 511
LEU A 445
 None
 1.18A 4m11A-5yfbA:
1.4		 4m11A-5yfbA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 ASP A 489
ARG A 394
THR A 312
 None
 0.58A 4p3rA-5yfbA:
undetectable		 4p3rA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 LEU A 548
GLY A 544
MET A 563
ILE A 651
PHE A 419
 None
 1.49A 4p6xE-5yfbA:
undetectable		 4p6xE-5yfbA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 HIS A 443
HIS A 448
TYR A 313
GLU A 501
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
None
ZN  A 801 (-2.0A)
 0.98A 4pahA-5yfbA:
undetectable		 4pahA-5yfbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 LEU A 618
HIS A 448
HIS A 443
GLU A 501
 None
ZN  A 801 (-3.1A)
ZN  A 801 (-3.2A)
ZN  A 801 (-2.0A)
 0.93A 4pahA-5yfbA:
undetectable		 4pahA-5yfbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 GLY A 275
ALA A 291
TYR A 390
ASN A 202
SER A 282
 None
 1.24A 4pb1A-5yfbA:
1.3		 4pb1A-5yfbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 4 ASN A 208
VAL A 205
THR A 240
ILE A 241
 None
 1.19A 4retA-5yfbA:
undetectable		 4retA-5yfbA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 4 ASN A 208
VAL A 205
THR A 240
ILE A 241
 None
 1.19A 4retC-5yfbA:
undetectable		 4retC-5yfbA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 ILE A 307
GLY A  49
ILE A  53
THR A 378
LEU A 404
 None
 1.02A 5e72A-5yfbA:
undetectable		 5e72A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 11 ALA A 541
ALA A 579
LEU A 573
LEU A 509
VAL A 603
 None
 1.20A 5eb5A-5yfbA:
undetectable		 5eb5A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 4 HIS A 443
HIS A 448
TYR A 313
GLU A 501
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
None
ZN  A 801 (-2.0A)
 0.96A 5pahA-5yfbA:
undetectable		 5pahA-5yfbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 MET A 540
GLU A 501
ARG A 566
 None
ZN  A 801 (-2.0A)
None
 0.70A 5tjyA-5yfbA:
undetectable		 5tjyA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 MET A 540
GLU A 501
ARG A 566
 None
ZN  A 801 (-2.0A)
None
 0.59A 5tjzA-5yfbA:
undetectable		 5tjzA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 ASP A 298
PHE A 399
ALA A 441
ALA A 370
GLU A 304
 None
 1.29A 5vcgA-5yfbA:
undetectable		 5vcgA-5yfbA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 7 VAL A 310
TRP A 323
PHE A 280
GLU A 324
 None
 1.38A 5vv9A-5yfbA:
undetectable
5vv9B-5yfbA:
undetectable		 5vv9A-5yfbA:
11.79
5vv9B-5yfbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 ILE A 478
PHE A 358
THR A 474
PRO A 472
 None
 1.07A 5x23A-5yfbA:
undetectable		 5x23A-5yfbA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 ARG A 649
PHE A 163
ARG A  10
 None
 1.18A 5y9yA-5yfbA:
undetectable		 5y9yA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 SER A 497
GLU A 494
ARG A 631
ASP A 489
 None
 1.27A 5zw4A-5yfbA:
undetectable		 5zw4A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 PHE A 280
GLY A 308
TYR A 390
TYR A 306
 None
 1.29A 6ag0A-5yfbA:
undetectable		 6ag0A-5yfbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 PHE A 280
GLY A 308
TYR A 390
TYR A 306
 None
 1.22A 6ag0C-5yfbA:
undetectable		 6ag0C-5yfbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		5 / 12 GLN A  54
GLY A  49
SER A 249
ALA A 218
VAL A 217
 None
 1.02A 6c2mC-5yfbA:
undetectable		 6c2mC-5yfbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 PHE A 115
ARG A 566
ALA A 383
 None
 0.92A 6ecfB-5yfbA:
undetectable		 6ecfB-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 8 GLN A 439
SER A 403
PHE A 521
TYR A 523
 None
 1.11A 6eqpA-5yfbA:
undetectable		 6eqpA-5yfbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		3 / 3 LYS A 238
VAL A 227
ASP A 229
 None
 0.54A 6fgdA-5yfbA:
undetectable		 6fgdA-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 THR A  71
LEU A  70
THR A 102
LEU A 149
 None
 1.17A 6mvxA-5yfbA:
undetectable
6mvxB-5yfbA:
undetectable
6mvxC-5yfbA:
undetectable		 6mvxA-5yfbA:
undetectable
6mvxB-5yfbA:
undetectable
6mvxC-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 HIS A 443
HIS A 448
TYR A 313
GLU A 501
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
None
ZN  A 801 (-2.0A)
 0.97A 6pahA-5yfbA:
undetectable		 6pahA-5yfbA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5yfb DIPEPTIDYL PEPTIDASE
3
(Armillaria
tabescens) 		4 / 6 LEU A 618
HIS A 448
HIS A 443
GLU A 501
 None
ZN  A 801 (-3.1A)
ZN  A 801 (-3.2A)
ZN  A 801 (-2.0A)
 0.79A 6pahA-5yfbA:
undetectable		 6pahA-5yfbA:
13.31