SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5yfp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		3 / 3 GLU C 591
ALA C 593
SER C 549
 None
 0.69A 1errB-5yfpC:
undetectable		 1errB-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 4 GLY C 540
LEU C 541
GLY C 539
ARG C 448
 None
 1.36A 1j7kA-5yfpC:
undetectable		 1j7kA-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 5 GLY C 588
GLN C 594
VAL C 647
SER C 549
 None
 1.37A 1p6kB-5yfpC:
undetectable		 1p6kB-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
EXOCYST COMPLEX
COMPONENT SEC5
(Saccharomyces
cerevisiae) 		5 / 12 ALA B 968
VAL H 691
LEU H 633
ILE H 668
PHE H 675
 None
 1.13A 1xozA-5yfpB:
undetectable		 1xozA-5yfpB:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		4 / 6 SER H 723
LEU H 715
ILE H 705
HIS H 701
 None
 0.96A 1yajF-5yfpH:
undetectable		 1yajF-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 5 GLY C 588
GLN C 594
VAL C 647
SER C 549
 None
 1.34A 1zzuB-5yfpC:
2.0		 1zzuB-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		3 / 3 LEU H 657
TYR H 656
GLN H 659
 None
 0.68A 2wekA-5yfpH:
undetectable		 2wekA-5yfpH:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		4 / 4 ILE H 640
GLN H 634
ILE H 668
LEU H 604
 None
 1.24A 3dzyD-5yfpH:
undetectable		 3dzyD-5yfpH:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 753
PHE C 720
ASP C 722
GLU C 726
 None
 1.12A 3kp6A-5yfpC:
undetectable
3kp6B-5yfpC:
undetectable		 3kp6A-5yfpC:
20.26
3kp6B-5yfpC:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		5 / 11 TYR C 738
TYR C 742
THR C 793
LEU C 665
GLN C 712
 None
 1.32A 4em0B-5yfpC:
undetectable		 4em0B-5yfpC:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 5 GLY C 540
GLY C 539
ASN C 521
GLU C 543
 None
 0.98A 4fglC-5yfpC:
undetectable		 4fglC-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 6 GLY C 540
GLY C 539
ASN C 521
GLU C 543
 None
 0.91A 4fglD-5yfpC:
undetectable		 4fglD-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 418
ASP C 421
TYR C 422
 None
 0.61A 4qc6B-5yfpC:
undetectable		 4qc6B-5yfpC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 6 ARG C 502
GLU C 438
PHE C 442
VAL C 592
 None
 1.37A 5h4dA-5yfpC:
undetectable		 5h4dA-5yfpC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_H_BBIH405_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		4 / 4 ARG C 502
GLU C 438
PHE C 442
VAL C 592
 None
 1.05A 5h4dH-5yfpC:
0.0		 5h4dH-5yfpC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		3 / 3 ASP H 696
ASN H 638
GLN H 634
 None
 0.75A 5k7uA-5yfpH:
undetectable		 5k7uA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		4 / 6 ASP H 642
ASP H 696
ASN H 638
GLN H 634
 None
 1.03A 5l6eA-5yfpH:
undetectable		 5l6eA-5yfpH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 672
SER C 673
LYS C 675
 None
 0.79A 5os7A-5yfpC:
undetectable		 5os7A-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5yfp EXOCYST COMPLEX
COMPONENT EXO84
(Saccharomyces
cerevisiae) 		4 / 6 ARG H 636
PHE H 675
ILE H 668
THR H 667
 None
 1.16A 5vceA-5yfpH:
undetectable		 5vceA-5yfpH:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5yfp EXOCYST COMPLEX
COMPONENT SEC6
(Saccharomyces
cerevisiae) 		3 / 3 HIS C 672
SER C 673
LYS C 675
 None
 0.79A 6gmdB-5yfpC:
undetectable		 6gmdB-5yfpC:
undetectable